Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas

Neoplasia

Volumn 4, Issue 4, 2002, Pages 337-346

  Dimitroulakos, Jim ^a   Marhin, Wilson H ^a   Tokunaga, Jason ^a   Irish, Jonathan ^a   Gullane, Patrick ^a   Penn, Linda Z ^a   Kamel Reid, Suzanne ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Apoptosis; Geranylgeranyl; HMG CoA reductase; Lovastatin; Squamous cell carcinoma

Indexed keywords

ACYL COENZYME A; DIAZEPAM BINDING INHIBITOR; FARNESYL DIPHOSPHATE; FARNESYL TRANS TRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEVINOLIN; RHO FACTOR; ACTIVATING TRANSCRIPTION FACTOR; CCAAT ENHANCER BINDING PROTEIN; CHOLESTEROL; COMMON CELLULAR TRANSCRIPTION FACTOR ATF; DNA BINDING PROTEIN; FLUORESCENT DYE; GERANYLGERANYL PYROPHOSPHATE; HMG-COA SYNTHASE; HYBRID PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; ISOPRENOID PHOSPHATE; LONG CHAIN FATTY ACID COENZYME A LIGASE; LUCIFERASE; MEVALONIC ACID; PHALLOIDIN; PLASMA PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SREBF1 PROTEIN, HUMAN; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR; TUMOR PROTEIN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TRANSCRIPTION REGULATION; UTERINE CERVIX CARCINOMA; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL STRAIN COS1; CELL SURVIVAL; CERCOPITHECUS; CONSENSUS SEQUENCE; DNA FINGERPRINTING; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HEAD AND NECK TUMOR; IMAGE SUBTRACTION; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION; REPORTER GENE; UTERINE CERVIX TUMOR; WESTERN BLOTTING;

ACTIVATING TRANSCRIPTION FACTORS; ANIMALS; APOPTOSIS; BLOOD PROTEINS; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CCAAT-ENHANCER-BINDING PROTEINS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CHOLESTEROL; COENZYME A LIGASES; CONSENSUS SEQUENCE; COS CELLS; DIAZEPAM BINDING INHIBITOR; DNA FINGERPRINTING; DNA-BINDING PROTEINS; FEMALE; FLUORESCENT DYES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HEAD AND NECK NEOPLASMS; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; LOVASTATIN; LUCIFERASES; MEVALONIC ACID; NEOPLASM PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHALLOIDINE; POLYISOPRENYL PHOSPHATES; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; RHOA GTP-BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROLS; SUBTRACTION TECHNIQUE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

EID: 0036020213     PISSN: 15228002     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.neo.7900247     Document Type: Article

References (43)

1. Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effect of sulindac
2. Rho signals to cell growth and apoptosis
3. Applications of microarray technology in breast cancer research
4. Pharmacology of competitive inhibitors of HMG-CoA reductase
5. Genomics and proteomics: The new millennium of drug discovery and development
6. Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach
7. Identification of a novel zinc finger gene, zf5-3, as a potential mediator of neuroblastoma differentiation
8. Lovastatin induces a pronounced differentiation response in acute myeloid leukemias
9. Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: Therapeutic implications
10. HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: Lovastatin specifically targets P-glycoprotein-expressing cells
11. Cdc25 as a potential target of anticancer agents
12. Regulation of gene expression by SREBP and SCAP
13. Induction of apoptosis in fibroblasts by c-myc protein
14. Rho family proteins in cell adhesion and cell migration
15. Apoptosis in cancer therapy: Crossing the threshold
16. Ras C-terminal processing enzymes - New drug targets?
17. Regulation of the mevalonate pathway
18. The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: Activating transcription factor proteins and homeostasis
19. HMG-CoA reductase inhibitors
20. Biochip technologies in cancer research
21. Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics
22. The regulatory role of MRP8 (S100A8) and MRP14 (S100A9) in the transendothelial migration of human leukocytes
23. The two calcium-binding proteins S100A8 and S100A9, are involved in the metabolism of arachidonic acid in human neutrophils
24. Apoptosis. Its significance in cancer and cancer therapy
25. Inhibition of epidermal growth factor-induced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors
26. The cdc25B phosphatase is essential for the G2/M phase transition in human cells
27. Non-Ras targets of farnesyltransferase inhibitors: Focus on Rho
28. Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein
29. Lovastatin-induced apoptosis of human medulloblastoma cell lines in vitro
30. Control of the ERK MAP kinase cascade by Ras and Raf
31. Application of comparative genomic hybridization, spectral karyotyping, and microarray analysis in the identification of subtype-specific patterns of genomic changes in rhabdomyosarcoma
32. Ras and Rho regulation of the cell cycle and oncogenesis
33. Farnesyltransferase and geranyl-geranyl transferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies
34. Application of the differential hybridization of Atlas Human expression arrays technique in the identification of differentially expressed genes in human glioblastoma multiforme tumor tissue
35. Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
36. Identification of diazepam-binding inhibitor/Acyl-CoA-binding protein as a sterol regulatory element-binding protein-responsive gene
37. Coordinate regulation of lipogenic gene expression by androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins
38. Small GTP-binding proteins
39. Phase 1 study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer
40. Novel lipid-regulating drugs
41. Mevalonate prevents lovastatin-induced apoptosis in medulloblastoma cell lines
42. BTEB2, a Kruppel-like transcription factor, regulates expression of the SMemb/nonmuscle myosin heavy chain B (SMemb/ NMHC-B) gene
43. Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells