Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics

International Journal of Biochemistry and Cell Biology

Volumn 28, Issue 6, 1996, Pages 619-637

  Kelley, Kevin M ^a,b   Oh, Youngman ^a   Gargosky, Sharron E ^a   Gucev, Zoran ^a   Matsumoto, Tomoko ^a   Hwa, Vivian ^a   Ng, Lilly ^a   Simpson, Diane M ^a   Rosenfeld, Ron G ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

Cancer; Diabetes mellitus; Growth regulation; IGFBP protease; Reproduction

Indexed keywords

SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 4; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN BINDING PROTEIN 6;

BIOSYNTHESIS; CELL GROWTH; DIABETES MELLITUS; DIABETIC NEPHROPATHY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GROWTH REGULATION; HISTOCHEMISTRY; HUMAN; MOLECULAR CLONING; NONHUMAN; PROSTATE CANCER; PROTEIN ANALYSIS; PROTEIN MODIFICATION; PROTEIN PROCESSING; RECEPTOR BINDING; REVIEW;

MAMMALIA;

EID: 0029930716     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/1357-2725(96)00005-2     Document Type: Review

References (151)

1. Adashi E. Y. (1994). Regulation of intrafollicular IGFBPs, possible relevance to ovarian follicular selection. In The Insulin-like Growth Factors and Their Regulatory Proteins (Edited by Baxter R. C., Gluckman P. D. and Rosenfeld R. G.), pp. 341-350. Elsevier, Amsterdam.
2. Andress D.L. and Birnbaum R.S. (1992) Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action. J. Biol. Chem. 267, 22467-22472.
3. Arany E., Afford S., Strain A.J., Winwood P.J., Arthur M.J.P. and Hill D.J. (1994) Differential cellular synthesis of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 within human liver. J. Clin. Endocrinol. Metab. 79, 1871-1876.
4. Bach L.A., Thotakura N.R. and Rechler M.M. (1993) Human insulin-like growth factor binding protein 6 is O-glycosylated. Growth Reg. 3, 59-62.
5. Baker J., Liu J.P., Robertson E.J. and Efstratiadis A. (1993) Role of insulin-like growth factors in embryonic, postnatal growth. Cell 75, 73-82.
6. Bang P., Brismar K. and Rosenfeld R.G. (1994) Increased proteolysis of insulin-like growth factor-binding protein-3 (IGFBP-3) in noninsulin-dependent diabetes mellitus serum, with elevation of a 29-kilodalton (kDa) glycosylated IGFBP-3 fragment contained in the approximately 130 to 150-kDa ternary complex. J. Clin. Endocrinol. Metab. 78, 1119-1127.
7. Bang P., Stangenberg M., Westgren M. and Rosenfeld R.G. (1994) Decreased ternary complex formation and predominance of a 29 kDa IGFBP-3 fragment in human fetal serum. Growth Regul. 4, 68-76.
8. Bar R. S., Boes M., Booth B. A., Dake B. L., Moser D. R. and Erondu N. E. (1994). Vascular endothelium, IGFs and IGF binding proteins. In The Insulin-like Growth Factors and Their Regulatory Proteins (Edited by Baxter R. C., Gluckman P. D. and Rosenfeld R. G.), pp. 237-244. Elsevier, Amsterdam.
9. Bar R.S., Boes M., Clemmons D.R., Busby W.H., Sandra A., Dake B.L. and Booth B.A. (1990) Insulin differentially alters transcapillary movement of intravascular IGFBP-1, IGFBP-2 and endothelial cell IGF binding proteins in rat heart. Endocrinology 127, 497-499.
10. Bar R.S., Booth B.A., Boes M. and Dake B.L. (1989) Insulin-like growth factor-binding proteins from vascular endothelial cells, purification, characterization, and intrinsic biological activities. Endocrinology 125, 1910-1920.
11. Baxter R.C. (1994) Insulin-like growth factor binding proteins in the human circulation, a review. Horm. Res. 42, 140-144.
12. Baxter R.C. and Saunders H. (1992) Radioimmunoassay of insulin-like growth factor-binding protein-6 in human serum and other body fluids. J. Endocrinol. 134, 133-139.
13. Bicsak T.A., Shimonaka M., Malkowski M. and Ling N. (1990) Insulin-like growth factor-binding (IGF-BP) inhibition of granulosa cell function, effect on cyclic adenosine 3′,5′-monophosphate, deoxyribonucleic acid synthesis, and comparison with the effect of an IGF-I antibody. Endocrinology 126, 2184-2189.
14. Binoux M., Roghani M., Hossenlopp P., Hardouin S. and Gourmelen M. (1991) Molecular forms of human IGF binding proteins, physiological implications. Acta Endocrinol. 124 Suppl. 2, 41-47.
15. Blum W.F., Horn N., Kratzch J., Jorgensen J.O.L., Juul A., Teale D., Mohnike K. and Ranke M.B. (1993) Clinical studies of IGFBP-2 by radioimmunoassay. Growth Regul. 3, 100-104.
16. Boes M., Booth B.A., Sandra A., Dake B.L., Bergold A. and Bar R.S. (1992) Insulin-like growth factor binding protein (IGFBP)4 accounts for the connective tissue distribution of endothelial cell IGFBPs perfused through the isolated heart. Endocrinology 133, 27-330.
17. Boni-Schnetzler M., Schmid C., Mary J.-L., Zimmerli B., Meier P.J., Zapf J., Schwander J. and Froesch E.R. (1990) Insulin regulates the expression of the insulin-like growth factor binding protein 2 mRNA in rat hepatocytes. Mol. Endocrinol. 4, 1320-1326.
18. Booth B.A., Boes M., Andress D.L., Dake B.L., Kiefer M.C., Maack C., Linhardt R.J. and Bar R.S. (1995) IGFBP-3 and IGFBP-5 association with endothelial cells: role of C-terminal heparin binding domain. Growth Regul. 5, 1-17.
19. Bourner M.J., Busby W.H., Seigel N.R., Krivi G.G., McCusker R.H. and Clemmons D.R. (1992) Cloning and sequence determination of bovine insulin-like growth factor binding protein-2 (IGFBP-2), comparison of its structural and functional properties with IGFBP-1. J. Cell. Biochem. 48, 215-226.
20. Brice A.L., Cheetham J.E., Bolton V.N., Hill N.C.W. and Schofield P.N. (1989) Temporal changes in the expression of insulin-like growth factor II gene associated with tissue maturation in the human fetus. Development 106, 543-554.
21. Brismar K. and Hall K. (1993) Clinical applications of IGFBP-1 and its regulation. Growth Regul. 3, 98-100.
22. Brown A.L. and Rechler M.M. (1990) Cloning of the rat insulin-like growth factor-binding protein-2 gene and identification of a functional promoter lacking a TATA box. Mol. Endocrinol. 4, 2039-2051.
23. Busby W.H., Klapper D.G. and Clemmons D.R. (1988) Purification of a 31000 dalton insulin-like growth factor binding protein from human amniotic fluid. J. Biol. Chem. 263, 14203-14210.
24. Camacho-Hubner C., Busby W.H., McCusker R.H., Wright G. and Clemmons D.R. (1992) Identification of the forms of insulin-like growth factor-binding proteins produced by human fibroblasts and the mechanisms that regulate their secretion. J. Biol. Chem. 267, 11949-11956.
25. Ceda G.P., Fielder P.J., Henzel W.J., Louie A., Donovan S.M., Hoffman A.R. and Rosenfeld R.G. (1991) Differential effects of insulin-like growth factor (IGF)-I and IGF-II on the expression of IGF binding proteins (IGFBPs) in a rat neuroblastoma cell line, isolation and characterization of two forms of IGFBP-4. Endocrinology 128, 2815-2824.
26. Chan K.C. and Nicoll C.S. (1994) Characterization of rat serum insulin-like growth factor-binding proteins by two-dimensional gel electrophoresis, identification of a potentially novel form. Endocrinology 134, 2574-2580.
27. Cheatham B. and Kahn C.R. (1995) Insulin action and the insulin signalling network. Endocrine Rev. 16, 117-142.
28. Cheung P.-T., Smith E.P., Shimasaki S., Ling N. and Chernausek S.D. (1991) Characterization of an insulin-like growth factor binding protein (IGFBP-4) produced by the B104 rat neuronal cell line, chemical and biological properties and differential synthesis by sublines. Endocrinology 129, 1006-1015.
29. Cheung P.-T., Wu J., Banach W. and Chernausek S. D. (1994) Glucocorticoid regulation of an insulin-like growth factor-binding protein-4 protease produced by a rat neuronal cell line. Endocrinology 135, 1328-1335.
30. Chin E., Zhou J., Dai J., Baxter R.C. and Bondy C. (1994) Cellular localization and regulation of gene expression for components of the insulin-like growth factor ternary binding complex. Endocrinology 134, 2498-2504.
31. Clemmons D.R. and Gardner L.I. (1990) A factor contained in plasma is required for IGF binding protein-1 to potentiate the effect of IGF-I on smooth muscle cell DNA synthesis. J. Cell. Physiol. 145, 129-135.
32. Clemmons D. R., Nam T. J., Busby W. H. and Parker A. (1994) Modification of IGF action by insulin-like growth factor binding protein-5. In The Insulin-like Growth Factors and Their Regulatory Proteins (Edited by Baxter R. C., Gluckman P. D. and Rosenfeld R. G.), pp. 183-191. Elsevier, Amsterdam.
33. Cohen P., Graves H.C.B., Kamarei M., Peehl D.M. and Rosenfeld R.G. (1991) Prostate specific antigen (PSA) is an IGF binding protein (IGFBP-3) protease found in seminal plasma. J. Clin. Endocrinol. Metab. 75, 1046-1053.
34. Cohen P., Lamson G., Okajima T. and Rosenfeld R.G. (1993) Transfection of the human insulin-like growth factor binding protein-3 gene into Balb/c fibroblasts inhibits cellular growth. Mol. Endocrinol. 7, 380-386.
35. Cohen P., Peehl D.M., Baker B., Liu F., Hintz R.L. and Rosenfeld R.G. (1994) Insulin-like growth factor axis abnormalities in prostatic stromal cells from patients with benign prostatic hyperplasia. J. Clin. Endocrinol. Metab. 79, 1410-1415.
36. Cohen P., Peehl D.M., Graves H.C.B. and Rosenfeld R.G. (1994) Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease. J. Endocrinol. 142, 407-415.
37. Cohen P., Peehl D.M., Stamey T.A., Wilson K., Clemmons D.R. and Rosenfeld R.G. (1993) Elevated levels of insulin-like growth binding protein-2 in the serum of prostate cancer patients. J. Clin. Endocrinol. Metab. 76, 830-835.
38. Cohick W.S., Gockerman A. and Clemmons D.R. (1993) Vascular smooth muscle cells synthesize two forms of insulin-like growth factor binding proteins which are regulated differently by the insulin-like growth factors. J. Cell. Physiol. 157, 52-60.
39. Conover CA. (1991) Glycosylation of insulin-like growth factor binding protein-3 (IGFBP-3) is not required for potentiation of IGF-I action, evidence for processing of cell-bound IGFBP-3. Endocrinology 129, 3259-3268.
40. Conover C.A. and De Leon D.D.D. (1994) Acid activated insulin-like growth factor-binding protein-3 proteolysis in normal and transformed cells. J. Biol. Chem. 269, 7076-7088.
41. Conover C.A. and Kiefer M.C. (1993) Regulation and biological effect of endogenous insulin-like growth factor binding protein-5 in human osteoblastic cells. J. Clin. Endocrinol. Metab. 76, 1153-1159.
42. Conover C.A., Kiefer M.C. and Zapf J. (1993) Posttranslational regulation of insulin-like growth factor binding protein-4 in normal and transformed human fibroblasts. J. Clin. Invest. 91, 1129-1137.
43. Conover C.A., Perry J.E. and Tindall D.J. (1995) Endogenous cathepsin D-mediated hydrolysis of insulin-like growth factor binding proteins in cultured human prostatic carcinoma cells. J. Clin. Invest. 80, 987-993.
44. Cubbage M.L., Suwanichkal A. and Powell D.R. (1990) Insulin-like growth factor binding protein-3. organization of the human chomosomal gene and demonstration of promoter activity. J. Biol. Chem. 265, 12642-12649.
45. Dai Z., Xing Y., Boney C.M., Clemmons D.R. and D'Ercole A.J. (1994) Human insulin-like growth factor-binding protein-1 (hIGFBP-1) in transgenic mice, characterization and insights into the regulation of IGFBP-1 expression. Endocrinology 135, 1316-1327.
46. Davenport M.L., Pucilowska J., Clemmons D.R., Lundblad R., Spencer J.A. and Underwood L.E. (1992) Tissue-specific expression of insulin-like growth factor-binding protein-3 protease activity during rat pregnancy. Endocrinology 130, 2505-2512.
47. Deal C. L., Guidice L. C., Lamson G. and Rosenfeld R. G. (1991) Production of insulin-like growth factors (IGFs), IGF-Binding proteins (IGFBPs) by human trophoblast. Proc. 2nd Int. Symp. Insulin-like Growth Factors/Somatomedins, San Francisco, CA (Astr. 124A).
48. Delbe J., Blat C., Desauty G. and Harel L. (1991) Presence of IDF45 (mIGFBP-3) binding sites on chick embryo fibroblasts. Biochem. Biophys. Res. Commun. 179, 495-501.
49. De Leon D.D., Wilson D.M., Powers M. and Rosenfeld R.G. (1992) Effects of insulin-like growth factors (IGFs) and IGF receptor antibodies on the proliferation of human breast cancer cells. Growth Factors 6, 327-336.
50. Delhanty P. J. D. and Han V. (1993) An RGD to RGE mutation in the putative membrane binding domain of IGFBP-2 inhibits its potentiation of IGF-II induced thymidine uptake by SCP cells. Proc. 75th Ann. Meet. Endocrine Soc., p. 56, abstract 22B.
51. Delhanty P.J.D., Hill D.J., Shimasaki S. and Han V.K.M. (1993) Insulin-like growth factor binding protein-4, -5 and -6 mRNAs in the human fetus, localization to sites of growth and differentiation. Growth Reg. 3, 8-11.
52. Duguay S.J., Chan S.J., Mommsen T.P. and Steiner D.F. (1995) Divergence of insulin-like growth factors I and II in the elasmobranch Squalus acanthias. FEBS Lett. 371, 69-72.
53. Durham S.K., De Leon D.D., Okazaki R., Riggs B.L. and Conover C.A. (1995) Regulation of insulin-like growth factor (IGF)-binding protein-4 availability in normal human osteoblast-like cells, role of endogenous IGFs. J. Clin. Endocrinol. Metab. 80, 104-110.
54. Falkmer S. (1985). Comparative morphology of pancreatic islets in animals. In The Diabetic Pancreas (Editors Volk B. W. and Arquilla E. R.), pp. 7-52. Plenum Press, New York.
55. Fielder P.J., Pham H., Adashi E.Y. and Rosenfeld R.G. (1993) Insulin-like growth factors (IGFs) block FSH-induced proteolysis of IGF-binding protein-5 (BP-5) in cultured rat granulosa cells. Endocrinology 133, 415-418.
56. Fielder P.J., Rosenfeld R.G., Graves H.C.B., Grandbois K., Maack C.A., Sawamura S., Ogawa Y., Sommer A. and Cohen P. (1994) Biochemical analysis of prostate specific antigen-proteolyzed insulin-like growth factor binding-3. Growth Regul. 1, 164-172.
57. Fielder P.J., Thordarson G., Talamantes F. and Rosenfeld R.G. (1990) Characterization of insulin-like growth factor binding proteins (IGFBPs) during gestation in mice, effects of hypophysectomy and an IGFBP specific serum protease activity. Endocrinology 127, 2270-2280.
58. Flyvbjerg A., Landau D., Domene H., Hernandez L. and LeRoith D. (1995) The role of growth hormone, insulin-like growth factors (IGFs) and IGF-binding proteins in experimental diabetic kidney disease. Metabolism (in press).
59. Fontana J.A., Burrows-Mezu A., Clemmons D.R. and LeRoith D. (1991) Retinoid modulation of insulin-like growth factor binding proteins and inhibition of breast carcinoma proliferation. Endocrinology 128, 1115-1122.
60. Fowlkes J. and Freemark M. (1992) Evidence for a novel insulin-like growth factor (IGF)-dependent protease regulating IGF-binding protein-4 in dermal fibroblasts. Endocrinology 131, 2071-2076.
61. Frost V.J., Macaulay V.M., Wass J.A.H. and Holly J.M.P. (1993) Proteolytic modification of insulin-like growth factor-binding proteins, comparison of conditioned media from human cell lines, circulating proteases and characterized enzymes. J. Endocrinol. 138, 545-554.
62. Gao L., Ling N. and Shimasaki S. (1993) Structure of the rat insulin-like growth factor binding protein-4 gene. Biochem. Biophys. Res. Commun. 190, 1053-1059.
63. Gargosky S. E., Giudice L. C., Rosenfeld R. G. and Fazleabas A. T. (1995) Different molecular and messenger ribonucleic acid forms of insulin-like growth factor binding protein-3 in the pregnant baboon (Papio anubis). J. Endocrinol. (in press)
64. Gargosky S.E., Walton P.E., Owens P.C., Wallace J.C., Robinson J.S. and Ballard F.J. (1990) Insulin-like growth factor-I (IGF-I) and IGF-binding proteins both decline in the rat during late pregnancy. J. Endocrinol. 127, 383-390.
65. Gargosky S.E., Wilson K.F., Fielder P.J., Vaccarello M.A., Guevara-Aguirre J., Diamond F.B., Baxter R.C., Rosenbloom A.L. and Rosenfeld R.G. (1993) The composition and distribution of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in the serum of growth hormone receptor-deficient patients, effects of IGF-I therapy on IGFBP-3. J. Clin. Endocrinol. Metab. 77, 1683-1689.
66. Gargosky S.E., Wilson K., Liu F., Guidice L.C. and Rosenfeld R.G. (1992) Measurement and characterization of insulin-like growth factor-binding protein-3 in human biological fluids, discrepancies between radio-immunoassay and ligand lotting reflect protease activity. Endocrinology 131, 3051-3060.
67. Giudice L.C., Dsupin B.A., De Las Fuentes L., Gargosky S.E., Rosenfeld R.G., Zelinski-Wooten M.B., Stouffer R.L. and Fazleabas A.T. (1993) Insulin-like growth factor binding proteins in sera of pregnant nonhuman primates. Endocrinology 132, 1514-1526.
68. Giudice L.C., de Zegher F., Gargosky S.E., Dsupin B.A., de las Fuentes L., Crystal R.A., Hintz R.L. and Rosenfeld R.G. (1995) Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth. J. Clin. Endocrinol. Metab. 80, 1548-1555.
69. Giudice L.C., Farrell E.M., Pham H., Lamson G. and Rosenfeld R.G. (1990) Insulin-like growth factor binding proteins in maternal serum throughout gestation and in the puerperium, effects of a pregnancy-associated serum protease activity. J. Clin. Endocrinol. Metab. 71, 806-816.
70. Giudice L. C., Irwin J. C., Dsupin B. A., de las Fuentes L., Jin I. H., Vu T. H. and Hoffman A. R. (1994). Insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs) and IGFBP protease in human uterine endometrium, their potential relevance to endometrial cyclic function and maternal-embryonic interactions. In The Insulin-like Growth Factors and Their Regulatory Proteins (Edited by Baxter R. C., Gluckman P. D. and Rosenfeld R. G.), pp. 351-361. Elsevier, Amsterdam.
71. Gucev Z., Oh Y., Kelley K. M. and Rosenfeld R. G. (1995) Role of insulin-like growth factor binding protein (IGFBP)-3 in a retinoic acid (RA) and transforming growth factor B (TGF-B) induced cell growth inhibition in MDA-231 human breast cancer cells. Proc. 77th Ann. Meet. Endocrine Soc., p. 169, Abstract P1-225.
72. Guler H.P., Zapf J., Schmid C. and Froesch E.R. (1989) Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rats. Acta Endocrinol. Copen. 121, 753-758.
73. Han V.K.M., D'Ercole A.J. and Lund P.K. (1987) Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in the human fetus. Science 236, 193-197.
74. Hise M.K., Mantzouris N.M., Lahn J.S., Sheikh M.S., Shao Z.-M. and Fontana J.A. (1994) IGF binding protein 5 and IGF-I receptor regulation in hypophysectomized rat kidneys. Am. J. Physiol. 266, F147-F154.
75. Hoeck W.G. and Mukku V.R. (1994) Identification of the major sites of phosphorylation in IGF binding protein-3. J. Cell. Biochem. 56, 262-273.
76. Holly M.P., Claffey D.C.P., Cwyfan-Hughes S.C., Frost V.J. and Yateman M.E. (1992) Proteases acting on IGFBPs, their occurrence and physiological significance. Growth Regul. 3, 88-91.
77. Hossenlopp P., Segovia B., Lassare C., Roghani M., Bredon M. and Binoux M. (1990) Evidence of enzymatic degradation of insulin-like growth factor-binding proteins in the 150K complex during pregnancy. J. Clin. Endocrinol. Metab. 71, 797-805.
78. Jones J.I. and Clemmons D.R. (1995) Insulin-like growth factors and their binding proteins, biological actions. Endocr. Rev. 16, 3-34.
79. Jones J.I, D'Ercole A.J., Camacho-Hubner C. and Clemmons D.R. (1991) Phosphorylation of insulin-like growth factor binding protein in cell culture and in vivo, effects on affinity for IGF-I. Proc. Natl Acad. Sci. U.S.A. 88, 7481-7485.
80. Jones J.I., Gockerman A., Busby W.H.Jr, Camacho-Hubner C. and Clemmons D.R. (1993) Extracellular matrix contains insulin-like growth factor binding protein-5, potentiation of the effects of IGF-I. J. Cell. Biol. 121, 679-687.
81. 1 integrin receptor by means of its Arg-Gly-Asp sequence. Proc. Natl Acad. Sci. U.S.A. 90, 10553-10557.
82. Keiss W., Grrenstein L.A., White R.M., Lee L. and Rechler M.M. (1987) Type II insulin-like growth factor receptor is present in rat serum. Proc. Natl Acad. Sci. U.S.A. 84, 7720-7724.
83. Kelley K. M., Nonoshita L. D. and Rosenfeld R. G. (1995) Insulin-like growth factor (IGF)-binding protein (IGFBP) gene expression in the hypertrophic kidney of rats with insulin-dependent diabetes mellitus (IDDM). Proc. 77th Ann. Meet. Endocrine Soc., p. 170.
84. Kelley K.M., Siharath K. and Bern H.A. (1992) Indentification of insulin-like growth factor-binding proteins in the circulation of four teleost fish species. J. Expl. Zool. 263, 220-224.
85. Kiefer M.C., loh R.S., Bauer D.M. and Zapf J. (1991) Molecular cloning of a new human insulin-like growth factor binding protein. Biochem. Biophys. Res. Commun. 176, 219-225.
86. Kiefer M.C., Masiarz F.R., Bauer D.M. and Zapf J. (1991) Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum. J. Biol. Chem. 266, 9043-9049.
87. Kiefer M.C., Schmid C., Waldvogel M., Schlapfer I., Futo E., Masiarz F.R., Green K., Barr P.J. and Zapf J. (1992) Characterization of recombinant human insulin-like growth factor-binding proteins 4, 5 and 6 produced in yeast. J. Biol. Chem. 267, 12692-12699.
88. Koistinen R., Angervo M., Leinonen P. and Seppala M. (1993) Phosphorylation of insulin-like growth factor-binding protien-1 from different sources. Growth Regul. 3, 34-36.
89. Koistinen R., Itkonen O., Selenius P. and Seppala M. (1990) Insulin-like growth factor-binding protein-1 inhibits binding of IGF-I on fetal skin fibroblasts but stimulates their DNA synthesis. Biochem. Biophys. Res. Commun. 173, 408-415.
90. Kou K., James P.L., Clemmons D.R., Copeland N.G., Gilbert D.J., Jenkins N.A. and Rotwein P. (1995) Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11. Genomics 21, 653-655.
91. Lamson G., Giudice L.C. and Rosenfeld R.G. (1991) Insulin-like growth factor binding proteins, structural and molecular relationships. Growth Factors 5, 19-28.
92. Lamson G., Giudice L.C., Cohen P., Lui F., Gargosky S.E., Muller H.L., Oh Y., Wilson K.F., Hintz R.L. and Rosenfeld R.G. (1992) Proteolysis of IGFBP-3 may be a common regulatory mechanism of IGF action in vivo. Growth Regul. 3, 91-94.
93. Lamson G., Pham H., Oh Y., Ocrant I., Schwander J. and Rosenfeld R.G. (1989) Expression of the BRL-3A insulin-like growth factor binding protein (rBP-30) in the rat central nervous system. Endocrinology 123, 1100-1102.
94. Landau D., Chin E., Bondy C., Domene H., Roberts C.T.Jr, Gronbaek H., Flyvbjerg A. and LeRoith D. (1995) Expression of insulin-like growth factor binding proteins in the rat kidney, effects of long-term diabetes. Endocrinology 136, 1835-1842.
95. Lee K.-O., Oh Y., Guidice L.C., Cohen P., Peehl D.M. and Rosenfeld R.G. (1994) Identification of insulin-like growth factor-Binding protein-3 (IGFBP-3) fragments and IGFBP-5 proteolytic activity in human seminal plasma, a comparison of normal and vasectomized patients. J. Clin. Endocrinol. Metab. 79, 1367-1372.
96. Lee P.D.K., Conover C.A. and Powell D.A. (1993) Regulation and function of insulin-like growth factor-binding protein-1. Proc. Soc. Expl. Biol. Med. 204, 4-29.
97. LeRoith D., Werner H., Beitner-Johnson D. and Roberts C.T.Jr (1995) Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr. Rev. 16, 143-163.
98. Lewitt M.S., Denyer G.S., Cooney G.J. and Baxter R.C. (1991) Insulin-like growth factor-binding protein-1 modulates blood glucose levels. Endocrinology 129, 2254-2256.
99. Lewitt M.S., Saunders H., Cooney G.J. and Baxter R.C. (1993) Effect of human insulin-like growth factor-binding protein-1 on the half-life and action of administered insulin-like growth factor-I in rats. J. Endocrinol. 136, 253-260.
100. Ling N., Liu X.-J., Malkowski M., Guo Y.-L., Erickson G.F. and Shimasaki S. (1993) Structural and functional studies of insulin-like growth factor binding proteins in the ovary. Growth Reg. 3, 70-74.
101. Liu F., Baxter R.C. and Hintz R.L. (1992) Characterization of the high molecular weight insulin-like growth factor complex in term pregnancy serum. J. Clin. Endocrinol. Metab. 75, 1261-1267.
102. Liu J.P., Baker J., Perkins A.S., Robertson E.J. and Efstratiadis A. (1993) Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1), type 1 IGF receptor (Igf1r). Cell 75, 59-72.
103. Liu L., Delbe J., Blat C., Zapf J. and Harel L. (1992) Insulin-like growth factor binding protein (IGFBP-3), an inhibitor of serum growth factors other than IGF-I and -II. J. Cell. Physiol. 153, 15-21.
104. McCusker R.H., Camacho-Hubner C., Bayne M.L., Cascieri M.A. and Clemmons D.R. (1990) Insulin-like growth factor (IGF) binding to human fibroblast and glioblastoma cells, the modulating effect of cell released IGF binding proteins (IGFBPs). J. Cell Physiol. 144, 244-253.
105. Martin J.L. and Baxter R.C. (1992) Insulin-like growth factor binding protein-3, biochemistry and physiology. Growth Regul. 2, 88-99.
106. Mohan S., Strong D. D., Linkhart T. A. and Baylink D. J. (1994) Regulation and actions of insulin-like growth factor binding protein (IGFBP)-4 and IGFBP-5 in bone, physiological and clinical implications. In The Insulin-like Growth Factors and Their Regulatory Proteins (Edited by Baxter R. C, Gluckman P. D. and Rosenfeld R. G.), pp. 205-215. Elsevier, Amsterdam.
107. Muller H.L., Oh Y., Gargosky S.E., Lehrnbecher T., Hintz R.L. and Rosenfeld R.G. (1993) Concentrations of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3), IGF, and IGFBP-3 protease activity in cerebrospinal fluid of children with leukemia, central nervous system tumor, or meningitis. J. Clin. Endocrinol. Metab. 77, 1113-1119.
108. Nam T.J., Busby W.H. and Clemmons D.R. (1994) Human fibroblasts secrete a serine protease that cleaves insulin-like growth factor-binding protein-5. Endocrinology 135, 1385-1391.
109. Neely E.K. and Rosenfeld R.G. (1992) Insulin-like growth factors (IGFs) reduce IGF-binding protein-4 (IGFBP-4) concentration and stimulate IGFBP-3 independently of IGF receptors in human fibroblasts and epidermal cells. Endocrinology 130, 985-993.
110. Nonoshita L.D., Wathen N.C., Dsupin B.A., Chard T. and Guidice L.C. (1994) Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and proteolyzed IGFBP-3 in embryonic cavities in early human pregnancy, their potential relevance to maternal-embryonic and fetal interactions. J. Clin. Endocrinol. Metab. 79, 1249-1255.
111. Oh Y., Muller H.L., Lamson G. and Rosenfeld R.G. (1993) Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. J. Biol. Chem. 268, 14964-14971.
112. Oh V., Muller H.L., Ng L. and Rosenfeld R.G. (1995) Transforming growth factor-β-induced cell growth inhibition in human breast cancer cells is mediated through insulin-like growth factor-binding protein-3 action. J. Biol. Chem. 270, 13589-13592.
113. Oh Y., Muller H.L., Pham H., Lamson G. and Rosenfeld R.G. (1992) Non-receptor mediated, post-transcriptional regulation of insulin-like growth factor binding protein (IGFBP)-3 in Hs578T human breast cancer cells. Endocrinology 131, 3123-3125.
114. Oh Y., Muller H.L., Pham H. and Rosenfeld R.G. (1993) Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells. J. Biol. Chem. 268, 26045-26048.
115. Okazaki R., Riggs L.B. and Conover C.A. (1994) Glucocorticoid regulation of insulin-like growth factor-binding protein expression in normal human osteoblast-like cells. Endocrinology 134, 126-162.
116. Orlowski C.C., Brown A.L., Ooi G.T., Yang Y.W.-H., Tseng L.Y.-H. and Rechler M.M. (1990) Tissue, developmental, and metabolic regulation of messenger ribonucleic acid encoding a rat insulin-like growth factor-binding protein. Endocrinology 126, 644-652.
117. Powell D.R., Suwanichkul A., Cubbage M.L., DePaolis L.A., Snuggs M.B. and Lee P.D.K. (1991) Insulin inhibits transcription of the human gene for insulin-like growth factor-binding protein-1. J. Biol. Chem. 266, 18868-18876.
118. Putowski L. T., Choi D. S., Mordacq J. et al. (1995) In vivo hormonal regulation of insulin-like growth factor binding protein-5 mRNA in the immature rat ovary. Mol. Cell Endocrinol. (in press)
119. Rashmi M., Strong D.D., Baylink D.J. and Mohan S. (1992) Stimulation of human bone cell proliferation by an antisense oligodeoxyribonucleotide to IGFBP-4 mRNA. J. Bone Min. Res. 1 suppl. 1, 5124.
120. Reeve J.G., Schwander J. and Bleehen N.M. (1993) IGFBP-2, an important regulator of insulin-like growth factor action in human lung tumors. Growth Regul. 3, 82-84.
121. Rodgers B. D., Strack A. M., Dallman M. F., Hwa L. and Nicoll C. S. (1995) Corticosterone regulation of insulin-like growth factor (IGF)-I, IGF binding proteins and growth in streptozotocin-diabetic rats. Diabetes (in press).
122. Roghani M., Lassarre C., Zapf J., Povoa G. and Binoux M. (1991) Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of cerebrospinal fluid binding proteins. J. Clin. Endocrinol. Metab. 73, 658-666.
123. Rohan R.M., Ricciarelli E., Kiefer M.C., Resnick C.E. and Adashi E.Y. (1993) Rat ovarian insulin-like growth factor-binding protein-6, a hormonally regulated thecainterstitial-selective species with limited antigonadotropic activity. Endocrinology 132, 2507-2512.
124. Rosenfeld R.G., Pham H., Cohen P., Fielder P., Gargosky S.E., Muller H., Nonoshita L. and Oh Y. (1994) Insulin-like growth factor binding proteins and their regulation. Acta Paediatr. Suppl. 339, 154-158.
125. Rosenfeld R.G., Pham H., Oh Y., Lamson G. and Guidice L.C. (1990) Identification of insulin-like growth factor-binding protein-2 (IGFBP-2) and a low molecular weight IGF-BP in human seminal plasma. J. Clin. Endocrinol. Metab. 70, 551-553.
126. 3 differentially regulates the production of IGF-I and IGFBP-4 in mouse osteoblasts. Endocrinology 129, 3139-3146.
127. Schmid C., Ernst M., Zapf J. and Froesch E.R. (1989) Release of insulin-like growth factor carrier proteins by osteoblasts. stimulation by estradiol and growth hormone. Biochem. Biophys. Res. Commun. 160, 788-794.
128. Schmid C., Rutishauser J., Schlapfer I., Froesch E.R. and Zapf J. (1991) Intact but not truncated insulin-like growth factor binding protein-3 (IGFBP-3) blocks IGF-I-induced stimulation off osteoblasts, control of IGF signalling to bone cells by IGFBP-3-specific proteolysis?. Biochem. Biophys. Res. Commun. 179, 579-585.
129. Sheikh M.S., Shao Z.-M., Hussain A., Clemmons D.R., Chen J.-C. Roberts C.T.Jr., LeRoith D. and Fontana J.A. (1993) Regulation of insulin-like growth factor-binding-protein-1, 2, 3, 4, 5 and 6 synthesis, secretion, and gene expression in estrogen receptor-negative human breast carcinoma cells. J. Cell. Physiol. 155, 556-567.
130. Shimasaki S., Gao L., Shimonaka M. and Ling N. (1991) Isolation and molecular cloning of insulin-like growth factor-binding protein-6. Mol. Endocrinol. 5, 938-948.
131. Shimasaki S. and Ling N. (1991) Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6). Progr. Growth Factor Res. 3, 243-266.
132. Shimasaki S., Shimonaka M., Zhang H.-P. and Ling N. (1991) Indentification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human. J. Biol. Chem. 266, 10646-10653.
133. Shimasaki S., Tanahashi H., Onoda N., Sumitomo S., Mickey G., Liu X.-J., Ling N., Li D. and Erickson G. (1994) Transcriptional and posttranscriptional regulation of IGFBP-4 and -5 in cultured rat granulosa cells. In The Insulin-like Growth Factors and Their Regulatory Proteins (Edited by Baxter R. C., Gluckman P. D. and Rosenfeld R. G.), pp. 193-204. Elsevier. Amsterdam.
134. Siharath K. and Bern H. A. (1993). The physiology of insulin-like growth factor (IGF) and its binding proteins in teleost fishes. Proc. Zool. Soc., Calcutta Haldane Comm. Vol., pp. 113-124.
135. Sommer A., Spratt S.K., Tatsuno G.P., Tressel T., Lee R. and Maack C.A. (1992) Properties of glycosylated and nonglycosylated human recombinant IGF binding protein-3 (IGFBP-3). Growth Regul. 3, 46-49.
136. Suikkari A.M. and Baxter R.C. (1992) Insulin-like growth factor-binding protein-3 is functionally normal in pregnancy serum. J. Clin. Endocrinol. Metab. 74, 177-183.
137. Swisshelm K., Ryan K., Tsuchiya K. and Sager R. (1995) Enhanced expression of an insulin growth factor-like binding protein (mac25) in senescent human mammary epithelial cells and induced expression with retinoic acid. Proc. Natl Acad. Sci. U.S.A. 92, 4472-4476.
138. Thissen J.-P., Ketelslegers J.-M. and Underwood L.E. (1994) Nutritional regulation of the insulin-like growth factors. Endocrine Rev. 15, 80-101.
139. Torring O., Firek A.F., Heath H.III and Conover C.A. (1991) Parathyroid hormone and parathyroid hormone-related peptide stimulated insulin-like growth factor-binding protein secretion by rat osteoblast-like cells through adenosine 3′,5′-monophosphate-dependent mechanism. Endocrinology 128, 1006-1014.
140. Unterman T.G., Jentell J.J., Oehler D.T., Lacson R.G. and Hofert J.F. (1993) Effects of glucocorticoids on circulating levels and hepatic expression of insulin-like growth factor (IGF)-binding proteins and IGF-I in the adrenalectomized streptozotocin-diabetic rat. Endocrinology 133, 2531-2539.
141. Unterman T.G., Simmons R.A., Glick R.P. and Ogata E.S. (1993) Circulating levels of insulin, insulin-like growth factor-I (IGF-I), IGF-II, and IGF-binding proteins in the small for gestational age fetal rat. Endocrinology 132, 327-336.
142. Upton A., Chan S.J., Steiner D.F., Wallace J.C. and Ballard F.J. (1992) Evolution of insulin-like growth factor binding proteins. Growth Regul. 3, 29-32.
143. Valentinis B., Bhala A., DeAngelis T., Baserga R. and Cohen P. (1995) The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene. Mol. Endocrinol. 361-367.
144. Villafuerte B.C., Koop B.L., Pao C-I., Gu L., Birdsong G.G. and Phillips L.S. (1994) Coculture of primary rat hepatocytes and nonparenchymal cells permits expression of insulin-like growth factor binding protein-3 in vitro. Endocrinology 134, 2044-2050.
145. Villaudy J., Delbe J., Blat C., Desauty G., Golde A. and Harel L. (1991) An IGF binding protein is an inhibitor off FGF stimulation. J. Cell. Physiol. 149, 492-496.
146. Westwood M., Gibson J.M., Davies A.J., Young R.J. and White A. (1994) The phosphorylation pattern of insulin-like growth factor-binding protein-1 in normal plasma is different from that in amniotic fluid and changes during pregnancy. J. Clin. Endocrinol. Metab. 79, 1735-1741.
147. Wood T.L., Brown A.L., Rechler M.M. and Pintar J.E. (1990) The expression pattern of an insuilin-like growth factor (IGF)-binding protein gene is distinct from IGF-II in the midgestational rat embryo. Mol. Endocrinol. 4, 1257-1263.
148. Wood T.L., Rogler L., Streck R.D., Cerro J., Green B., Grewal A. and Pintar J.E. (1993) Targeted disruption of IGFBP-2 gene. Growth Regul. 3, 5-8.
149. Yee D., Paik S., Lebovic G.S., Marcus R.R., Favoni R.E., Cullen K.J., Lippman M.E. and Rosen N. (1989) Analysis of insulin-like growth factor I gene expression in malignancy, evidence for a paracrine role in human breast cancer. Mol. Endocrinol. 3, 509-517.
150. Zhou J., Dsupin B. A., Giudice L. C. and Bondy C. A. (1994) Insulin-like growth factor system gene expression in human endometrium during the menstrual cycle. 79, 1723-1734.
151. Zugmaier G., Ennis B.W., Deschauer B., Katz D., Knabbe C., Wilding G., Daly P., Lippman M.E. and Dickson R.B. (1989) Transforming growth factors type β1 and β2 are equipotent growth inhibitors of human breast cancer cell lines. J. Cell. Phvsiol. 141, 353-361.