The regulatory role of MRP8 (S100A8) and MRP14 (S100A9) in the transendothelial migration of human leukocytes

Pathobiology

Volumn 67, Issue 5-6, 1999, Pages 230-232

  Kerkhoff, Claus ^a,b   Eue, Ines ^a   Sorg, Clemens ^a  

^a Inst of Experimental Dermatology   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Adhesion; Arachidonic acid; Inflammation; Secretion; 2 integrins

Indexed keywords

CALGRANULIN; CELL ADHESION MOLECULE;

CELL MIGRATION; CELL SURFACE; CONFERENCE PAPER; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE; MONOCYTE; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0342905417     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028098     Document Type: Conference Paper

References (12)

1. Kligman D, Hilt DC: The S100 protein family. Trends Biochem Sci 1988;13:437-443.
2. Kerkhoff C, Klempt M, Sorg C: Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). Biochim Biophys Acta 1998;1448:200-211.
3. Rammes A, Roth J, Goebeler M, Klempt M, Hartmann M, Sorg C: Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J Biol Chem 1997;272:9496-9502.
4. Newton RA, Hogg N: The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils. J Immunol 1998; 160:1427-1435.
5. Eue I, Pietz B, Klempt M, Sorg C: Regulation of transendothelial migration of human monocytes by the macrophage-inhibitory-factor-related-protein 8 (S100A8) and 14 (S100A9). Submitted.
6. Kerkhoff C, Klempt M, Kaever V, Sorg C: The two calcium-binding proteins S100A8 and S100A9 are involved in the metabolism of arachidonic acid in human neutrophils. J Biol Chem 1999;274:32672-32679.
7. Vogl T, Roth J, Sorg C, Hillenkamp F, Strupat K: Calcium-induced noncovalently-linked tetramers of MRP8 and MRP14 detected by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry. J Am Soc Mass Spectrom 1999;10:1024-1030.
8. Roth J, Burwinkel F, van den Bos C, Goebeler M, Vollmer E, Sorg C: MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner. Blood 1993;82:1875-1883.
9. Hetland G, Talgo GJ, Fagerhol MK: Chemotaxins C5a and fMLP induce release of calprotectin (leucocyte L1 protein) from polymorphonuclear cells in vitro. Mol Pathol 1998;51:143-148.
10. Karim S, Habib A, Levy-Toledano S, Maclouf J: Cyclooxygenase-1 and -2 of endothelial cells utilize exogenous or endogenous arachidonic acid for transcellular production of thromboxane. J Biol Chem 1996;271:12042-12048.
11. De Caterina R, Bernini W, Carluccio MA, Liao JK, Libby P: Control of endothelial leukocyte adhesion molecules by fatty acids. J Lipid Res 1998;39:1062-1070.
12. Kerkhoff C, Vogl T, Nacken W, Sopalla C, Sorg C: Zinc-binding reverses the calcium-induced arachidonic acid-binding capacity of the S100A8/A9 protein complex. FEBS Lett 1999; 460:134-138.