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Volumn 10, Issue 6, 2002, Pages 1829-1839

Novel morpholinone-based D-Phe-Pro-Arg mimics as potential thrombin inhibitors: Design, synthesis, and X-ray crystal structure of an enzyme inhibitor complex

(6) Dahlgren, Anders a Johansson, Per Ola a Kvarnström, Ingemar a Musil, Djordje b Nilsson, Ingemar b Samuelsson, Bertil c,d

a LINKÖPING UNIVERSITY (Sweden)

b ASTRAZENECA R AND D (Sweden)

c STOCKHOLM UNIVERSITY (Sweden)

d MEDIVIR AB (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 AMINOMETHYL 3 METHYLPYRIDINE; 4 AMIDINOBENZYLAMINE; ARGININE DERIVATIVE; BENZYLAMINE DERIVATIVE; CVS 1578; INOGATRAN; MALIC ACID; MORPHOLINE DERIVATIVE; PHENYLALANINE DERIVATIVE; PICOLINE DERIVATIVE; PROLINE DERIVATIVE; THROMBIN INHIBITOR; TRIPEPTIDE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; OLIGOPEPTIDE; PHENYLALANYL PROLYL ARGININE; PHENYLALANYL-PROLYL-ARGININE; THROMBIN;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; IC 50; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; MOLECULAR MIMICRY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; MORPHOLINES; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 0036009881 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/S0968-0896(02)00023-8 Document Type: Article

Times cited : (18)

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