Highly selective mechanism-based thrombin inhibitors: Structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes

Biochemistry

Volumn 37, Issue 35, 1998, Pages 12094-12103

  Krishnan, R ^a   Zhang, E ^a,c   Hakansson, K ^a   Arni, R K ^a   Tulinsky, A ^a   Lim Wilby, M S L ^b   Levy, O E ^b   Semple, J E ^b   Brunck, T K ^b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Dendreon   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBIN INHIBITOR;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SYNTHESIS; HEMOSTASIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ALDEHYDES; ANIMALS; BINDING SITES; CATTLE; GLYCINE; GUANIDINES; HUMANS; KINETICS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPERIDINES; SERINE PROTEINASE INHIBITORS; SUBSTRATE SPECIFICITY; THROMBIN; TRYPSIN; TRYPSIN INHIBITORS;

EID: 0032167901     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980840e     Document Type: Article

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