Potent and selective thrombin inhibitors featuring hydrophobic, basic P3-P4-aminoalkyllactam moieties

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 24, 1998, Pages 3525-3530

  Semple, J Edward ^a   Rowley, David C ^a   Owens, Timothy D ^a   Minami, Nathaniel K ^a   Uong, Theresa H ^a   Brunck, Terence K ^a  

^a Dendreon   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDE; LACTAM DERIVATIVE; SERINE PROTEINASE INHIBITOR; SULFONAMIDE; THROMBIN INHIBITOR;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HYDROPHOBICITY; MOLECULAR MIMICRY; STRUCTURE ACTIVITY RELATION;

ANTITHROMBINS; LACTONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032535670     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00636-2     Document Type: Article

References (39)

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