Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties

Journal of Medicinal Chemistry

Volumn 39, Issue 23, 1996, Pages 4531-4536

  Semple, J E ^a   Rowley, D C ^a   Brunck, T K ^a   Ha Uong, T ^a   Minami, N K ^a   Owens, T D ^a   Tamura, S Y ^a   Goldman, E A ^a   Siev, D V ^a   Ardecky, R J ^a   Carpenter, S H ^a   Ge, Y ^a   Richard, B M ^a   Nolan, T G ^a   Hakanson, K ^a   Tulinsky, A ^a   Nutt, R F ^a   Ripka, W C ^a  

^a Dendreon   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE DERIVATIVE; CVS 1123; CVS 1578; LACTAM DERIVATIVE; SERINE PROTEINASE INHIBITOR; SULFONAMIDE; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTICOAGULANT THERAPY; ARTICLE; CRYSTAL STRUCTURE; DOG; DRUG BIOAVAILABILITY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION; THROMBOSIS;

ANIMALS; ANTITHROMBINS; ARGININE; BIOLOGICAL AVAILABILITY; DOGS; DRUG DESIGN; LACTAMS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029803557     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960572n     Document Type: Article

References (0)