Large scale preparation of protected 4-aminomethylbenzamidine. Application to the synthesis of the thrombin inhibitor, melagatran

Synthetic Communications

Volumn 28, Issue 23, 1998, Pages 4419-4429

  Lila, Christine ^a   Gloanec, Philippe ^a   Cadet, Laurence ^a   Hervé, Yolande ^b   Fournier, Jean ^b   Leborgne, Fabrice ^b   Verbeuren, Tony J ^a   De Nanteuil, Guillaume ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^b ORIL Industrie   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BENZAMIDINE DERIVATIVE; MELAGATRAN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; FIBRINOLYTIC THERAPY; FRANCE; THROMBOSIS;

EID: 0031794772     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1080/00397919808004477     Document Type: Article

References (3)

1. Antonsson, K.; Bylund,R.; Gustafsson, N.; Nilsson, N. World Patent 1994, 94 29336.
2. Gustafsson, D.; Antonsson, T.; Bylund, R.; Eriksson, U.; Gyzander, E.; Nilsson, I.; Elg, M.; Mattsson, C.; Deinum, J.; Persson, S.; Karlsson, O.; Nilsson, A.; Sorensen, H. Thromb. Haemostasis 1997, Suppl., PS 2032.
3. Judkins, B. D.; Allen, D. G.; Cook, T. A.; Evans, B.; Sardharwala, T. E. Synthetic Comm. 1996, 26, 4351-4367.