The role of p38 mitogen-activated protein kinase in myocardial ischemia/reperfusion injury; Relationship to ischemic preconditioning

Basic Research in Cardiology

Volumn 97, Issue 4, 2002, Pages 276-285

  Steenbergen, Charles ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

Ischemic preconditioning; Myocardial ischemia; p38 mitogen activated protein kinase; Reperfusion; Signal transduction

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 8 (4 SULFOPHENYL)THEOPHYLLINE; ADENOSINE RECEPTOR BLOCKING AGENT; ALPHA B CRYSTALLIN; ALPHA CRYSTALLIN; ANISOMYCIN; GLUCOSE; GLUCOSE TRANSPORTER 4; HEAT SHOCK PROTEIN 27; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; SB 242719; SYNAPTOPHYSIN; SYNAPTOPHYSIN INHIBITOR; UNCLASSIFIED DRUG; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANAEROBIC GLYCOLYSIS; DISEASE ASSOCIATION; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EVIDENCE BASED MEDICINE; GLUCOSE TRANSPORT; HEART INFARCTION; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; MEDICAL LITERATURE; METABOLIC REGULATION; NONHUMAN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; PROTEIN TRANSPORT; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; STRESS; ANIMAL; METABOLISM;

ANIMAL; HUMAN; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIAL REPERFUSION INJURY; SIGNAL TRANSDUCTION; ANIMALS; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES;

EID: 0035997537     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-002-0364-9     Document Type: Review

References (39)

1. Phosphorylation state of hsp27 and p38 MAPK during preconditioning and protein phosphatase inhibitor protection of rabbit cardiomyocytes
2. Role of p38 mitogen-activated protein kinase in cardiac myocyte secretion of the inflammatory cytokine TNFalpha
3. Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic cell death
4. Inconsistent relation of MAPK activation to infarct size reduction by ischemic preconditioning in pigs
5. Stimulation of the stress-activated mitogen-activated protein kinase sub-families in perfused heart: p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion
6. p38 MAPK inhibition decreases TNF-alpha production and enhances postischemic human myocardial function
7. The p38-MAPK inhibitor, SB 203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs)
8. p38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against beta-adrenergic receptor-stimulated apoptosis
9. AlphaB crystallin translocation and phosphorylation: Signal transduction pathways and preconditioning in the isolated rat heart
10. Stress-activated protein kinase phosphorylation during cardioprotection in the ischemic myocardium
11. p38 MAPK activity is not increased early during sustained coronary artery occlusion in preconditioned versus control rabbit heart
12. Ischemia induced activation of heat shock protein 27 kinases and casein kinase 2 in the preconditioned rabbit heart
13. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase
14. Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion
15. An inhibitor of p38 mitogen-activated protein kinase protecting neonatal cardiac myocytes from ischemia
16. Involvement of a p38 mitogen-activated protein kinase phosphatase in protecting neonatal rat cardiac myocytes from ischemia
17. Activation of p38 MAPK induced by a multi-cycle ischaemic preconditioning protocol is associated with attenuated p38 MAPK activity during sustained ischaemia and reperfusion
18. Antiischemic effects of SB203580 are mediated through the inhibition of p38alpha mitogen-activated protein kinase
19. Ischemic preconditioning triggers the activation of MAP kinases and MAPKAP kinase 2 in rat hearts
20. Ischemic preconditioning triggers tyrosine kinase signaling: A potential role for MAPKAP kinase 2
21. Mitogen-activated protein kinases in the heart
22. The p38 MAPK inhibitor, SB 203580, abrogates ischaemic preconditioning in rat heart but timing of administration is critical
23. Role of p38 MAP kinase in myocardial stress
24. Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart. Evidence for involvement of p38 MAPK
25. PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits
26. PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits
27. Role of phasic dynamism of p38 mitogen-activated protein kinase activation in ischemic preconditioning of the canine heart
28. The role of differential activation of p38-mitogen activated protein kinase in preconditioned ventricular myocytes
29. Inhibition of p38 MAPK alpha/beta reduces ischemic injury and does not block protective effects of preconditioning
30. Activation of mitogen-activated protein kinases and activator protein-1 in myocardial infarction in rats
31. Activation of mitogen-activated protein kinases in human heart during cardiopulmonary bypass
32. Oxidative stress induces DNA fragmentation and caspase activation via the c-Jun NH2-terminal kinase pathway in H9c2 cardiac muscle cells
33. Preconditioning enhanced glucose uptake is mediated by p38 MAP kinase not by phosphatidylinositol-3-kinase
34. Ischemic preconditioning activates phosphatidylinositol-3-kinase up-stream of protein kinase C
35. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 MAPK family
36. Phosphorylation of tyrosine 182 of p38 mitogen-activated protein kinase correlates with the protection of preconditioning in the rabbit heart
37. Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney
38. Pyridinylimidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
39. Inhibition of extracellular signal-regulated kinase enhances ischemia/reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart