The p38 MAPK inhibitor, SB203580, abrogates ischaemic preconditioning in rat heart but timing of administration is critical

Basic Research in Cardiology

Volumn 95, Issue 6, 2000, Pages 472-478

  Mocanu, M M ^a   Baxter, G F ^a   Yue, Y ^a   Critz, S D ^a   Yellon, D M ^a  

^a UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Infarct size; Ischaemic preconditioning; p38 MAPK; SB203580

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; MITOGEN ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART PROTECTION; ISCHEMIA; ISOLATED HEART; MALE; NONHUMAN; RAT; TIME;

ANIMALS; CORONARY CIRCULATION; DRUG ADMINISTRATION SCHEDULE; ENZYME INHIBITORS; HEART; IMIDAZOLES; ISCHEMIC PRECONDITIONING; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIAL INFARCTION; MYOCARDIUM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PRESSURE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; VENTRICULAR FUNCTION, LEFT;

EID: 0034537885     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950070023     Document Type: Article

References (24)

1. Signal transduction in ischaemic preconditioning: The role of kinases and mitochondrial K ATP channels
2. Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischaemic cell death
3. Delayed myocardial protection following ischaemic preconditioning
4. Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischaemia/reperfusion
5. p38 MAPK inhibition decreases TNF-alpha production and enhances postischaemic human myocardial function
6. Delayed cardioprotection in a human cardiomyocyte-derived cell line: The role of adenosine, p38MAP kinase and mitochondrial KATP
7. Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses
8. The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs)
9. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
10. Adenosine A1 receptor induced delayed preconditioning in rabbits: induction of p38 mitogen-activated protein kinase activation and hsp 27 prosphorylation via a tyrosine kinase and protein kinase C dependent mechanism
11. Preconditioning - A reappraisal of protection
12. Stimulation of c-Jun kinase and mitogen-activated protein kinase by ischaemia and reperfusion in the perfused rat heart
13. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase
14. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
15. Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after ischaemia and reperfusion
16. An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischaemia
17. Ischaemic preconditioning triggers the activation of MAP kinases and MAP-KAP kinase 2 in rat heart
18. Ischaemic preconditioning triggers tyrosine kinase signaling: A potential role for MAPKAP kinase 2
19. Ischaemic preconditioning activates MAP-KAPK2 in the isolated rabbit heart: Evidence for involvement of p38 MAPK
20. Role of p38 mitogen-activated protein kinases in pre-conditioning. A detrimental factor or protective kinase?
21. Translocation of hsp 27 to sarcomere induced by ischaemic preconditioning in isolated rat hearts
22. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family
23. Phosphorylation of tyrosine 182 of p38 mitogen-activated protein kinase correlates with the protection of preconditioning in the rabbit heart
24. Inhibition of extracellular signal-regulated kinase enhances ischaemia/reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart