Nk6, a novel Drosophila homeobox gene regulated by vnd

Mechanisms of Development

Volumn 116, Issue 1-2, 2002, Pages 105-116

  Uhler, Jay ^a   Garbern, James ^b,c   Yang, Li ^b   Kamholz, John ^b   Mellerick, Dervla M ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c KARMANOS CANCER INSTITUTE   (United States)

Author keywords

Central nervous system; Drosophila; Homeobox; Nkx; vnd

Indexed keywords

HOMEODOMAIN PROTEIN; PROTEIN; PROTEIN VND; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NK6; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; COMPLEMENTARY DNA; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; HGTX PROTEIN, DROSOPHILA; MESSENGER RNA; NKX6.2 PROTEIN, VERTEBRATE; NUCLEAR PROTEIN; SIM PROTEIN, DROSOPHILA; VND PROTEIN, DROSOPHILA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DROSOPHILA; HEAD; INTESTINE; NERVE CELL; NEURAL TUBE; NEUROBLAST; NEUROECTODERM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; VENTRAL ROOT; AMINO ACID SEQUENCE; ANIMAL; CENTRAL NERVOUS SYSTEM; COMPARATIVE STUDY; GENE; GENE EXPRESSION REGULATION; GENETICS; HOMEOBOX; IN SITU HYBRIDIZATION; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MUTATION; PRENATAL DEVELOPMENT; SEQUENCE HOMOLOGY; TRANSGENIC ANIMAL; VERTEBRATE;

AMINO ACID SEQUENCE; ANIMAL; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; CENTRAL NERVOUS SYSTEM; COMPARATIVE STUDY; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; GENES, INSECT; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; MOLECULAR SEQUENCE DATA; MUTATION; NEURONS; NUCLEAR PROTEINS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION FACTORS; VERTEBRATES; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS;

VERTEBRATA;

EID: 0035996961     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(02)00155-7     Document Type: Article

References (67)

1. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
2. Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocyte myelination
3. The fate of the CNS midline progenitors in Drosophila as revealed by a new method for single cell labelling
4. The embryonic central nervous system lineages of Drosophila melanogaster. I. Neuroblast lineages derived from the ventral half of the neuroectoderm
5. New Pou dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2
6. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
7. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signaling
8. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
9. New neuroblast markers and the origin of the aCC/pCC neurons in the Drosophila central nervous system
10. Mechanisms of early neurogenesis in Drosophila melanogaster
11. Formation and specification of ventral neuroblasts is controlled by vnd in Drosophila neurogenesis
12. The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product
13. Drosophila single-minded gene and the molecular genetics of CNS midline development
14. Msh may play a conserved role in dorsoventral patterning of the neuroectoderm and mesoderm
15. Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear Engrailed protein
16. Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system
17. Neurogenesis in the insect central nervous system
18. Identification and cell lineage of individual neural precursors in the Drosophila CNS
19. Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome
20. Characterization and localization of the Even-skipped protein of Drosophila
21. Cell recognition during neuronal development
22. Genetic analysis of growth cone guidance in Drosophila: Fasciclin II functions as a neuronal recognition molecule
23. The homeobox gene repo is required for the differentiation and maintenance of glia function in the embryonic nervous system of Drosophila melanogaster
24. On global sequence alignment
25. Commissure formation in the embryonic CNS of Drosophila
26. Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development
27. The role of the msh homeobox gene during Drosophila neurogenesis: Implication for the dorsoventral specification of the neuroectoderm
28. Conversion of a dorsal-dependent silencer into an enhancer: Evidence for dorsal corepressors
29. Defective neuroblast commitment in mutants of the achaete-scute complex and adjacent genes of D. melanogaster
30. Vnd, a gene required for early neurogenesis of Drosophila, encodes a homeodomain protein
31. Regulation of POU genes by Castor and Hunchback establishes layered compartments in the Drosophila CNS
32. Dosage-sensitive and complementary functions of Roundabout and Commissureless control axon crossing of the CNS midline
33. The Ets transcription factors encoded by the Drosophila gene pointed direct glial cell differentiation in the embryonic CNS
34. Role of the midline glia and neurons in the formation of the axon commissures in the central nervous system of the Drosophila embryo
35. The midline of the Drosophila central nervous system: A model for the genetic analysis of cell fate, cell migration, and growth cone guidance
36. Gtx: A novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter
37. In situ hybridization to RNA
38. Establishing neuroblast-specific gene expression in the Drosophila CNS: Huckebein is activated by Wingless and Hedgehog and repressed by Engrailed and Gooseberry
39. Dorsoventral patterning in the Drosophila central nervous system: The vnd homeobox gene specifies ventral column identity
40. Regulated vnd expression is required for both neural and glial specification in Drosophila
41. Dorsal-ventral patterning genes restrict NK-2 homeobox gene expression to the ventral half of the central nervous system of Drosophila embryos
42. β-Cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains
43. Groucho- mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
44. The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells
45. Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes
46. The role of segment polarity genes during Drosophila neurogenesis
47. Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development
48. Conservation of the expression and function of apterous orthologs in Drosophila and mammals
49. Screening expression libraries with antibodies and oligonucleotides
50. Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates
51. Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
52. The embryonic central nervous system lineages of Drosophila melanogaster. II. Neuroblast lineages derived from the dorsal part of the neuroectoderm
53. The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo
54. Regulation of proneural gene expression and cell fate during neuroblast segregation in the Drosophila embryo
55. The ventral nervous system defective gene controls proneural gene expression at two distinct steps during neuroblast formation in Drosophila
56. Mice lacking the homeodomain transcription factor Nkx-2.2 have diabetes due to arrested differentiation of pancreatic β cells
57. A non-radioactive in situ hybridization method for localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback
58. Differential effects of EGF receptor signaling on neuroblast lineages along the dorsoventral axis of the Drosophila CNS
59. Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motorneuron and interneuron specification
60. Convergence of dorsal, Dpp, and Egfr signaling pathways subdivides the Drosophila neuroectoderm into three dorsal-ventral columns
61. Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1
62. Dorsoventral patterning in the Drosophila central nervous system: The intermediate neuroblasts defective homeobox gene specifies intermediate column identity
63. Repo encodes a glial-specific homeodomain protein required in the Drosophila nervous system
64. Interaction between Drosophila EGF receptor and vnd determines three dorsoventral domains of the neuroectoderm
65. Early neurogenesis of the Drosophila brain
66. The NK-2 homeobox gene scarecrow (scro) is expressed in pharynx, ventral nerve cord and brain of Drosophila embryos
67. The Sox-domain containing gene Dichaete/fish-hook acts in concert with vnd and ind to regulate cell fate in the Drosophila neuroectoderm