Presence of intact vpu and nef genes in nonpathogenic SHIV is essential for acquisition of pathogenicity of this virus by serial passage in macaques

Virology

Volumn 295, Issue 1, 2002, Pages 133-146

  Mackay, Glenn A ^a   Niu, Yafen ^a   Liu, Zhen Qian ^a   Mukherjee, Sampa ^a   Li, Zhuang ^a   Adany, Istvan ^a   Buch, Shilpa ^a   Zhuge, Wu ^a   McClure, Harold M ^b   Narayan, Opendra ^a   Smith, Marilyn S ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

HIV; nef; Pathogenicity; SHIV; Vaccine; vpu

Indexed keywords

CD4 ANTIGEN; RNA; VIRUS RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CELL LOSS; CONTROLLED STUDY; GENE; GENETIC ANALYSIS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPH NODE; MACACA; MONITORING; MONONUCLEAR CELL; NEF GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY MECHANISM; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE; TIME; VIRUS INFECTION; VIRUS LOAD; VIRUS MUTATION; VIRUS PATHOGENESIS; VIRUS REPLICATION; VPU GENE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; MACACA; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0035995683     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2002.1368     Document Type: Article

References (55)

1. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques
2. Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques
3. Reduction of simian-human immunodeficiency virus 89.6P viremia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination
4. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
5. Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques
6. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
7. NFAT1 enhances HIV-1 gene expression in primary human CD4 T cells
8. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
9. Viral protein u (vpu)-mediated enhancement of human immunodeficiency virus type 1 particle release depends on the rate of cellular proliferation
10. Simian immunodeficiency virus (SIV) gag DNA-vaccinated rhesus monkeys develop secondary cytotoxic T-lymphocyte responses and control viral replication after pathogenic SIV infection
11. Membrane-fusing capacity of the human immunodeficiency virus envelope proteins determines the efficiency of CD4+ T-cell depletion in macaques infected with simian-human immunodeficiency virus
12. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
13. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
14. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy
15. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
16. Protection of Macaca nemestrina from disease following pathogenic simian immunodeficiency virus (SIV) challenge: Utilization of SIV nucleocapsid mutant DNA vaccines with and without an SIV protein boost
17. Mucosal challenge of Macaca nemestrina with simian immunodeficiency virus (SIV) following SIV nucleocapsid mutant DNA vaccination
18. Sensitive and robust one-tube real-time reverse transcriptase-polymerase chain reaction to quantify SIV RNA load: Comparison of one- versus two-enzyme systems
19. Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques
20. Animal model of mucosally transmitted human immunodeficiency virus type 1 disease: Intravaginal and oral deposition of simian/human immunodeficiency virus in macaques results in systemic infection, elimination of CD4+ T cells, and AIDS
21. Characterization of the pathogenic KU-SHIV model of acquired immunodeficiency syndrome in macaques
22. Chimeric simian/human immunodeficiency virus that causes progressive loss of CD4+ T cells and AIDS in pig-tailed macaques
23. Oral immunization of macaques with attenuated vaccine virus induces protection against vaginally transmitted AIDS
24. Chimeric SHIV that causes CD4+ T cell loss and AIDS in rhesus macaques
25. Protective immunity induced by live attenuated simian immunodeficiency virus
26. Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: Inverse relationship of degree of protection with level of attenuation
27. Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys
28. Importance of the nef gene for maintenance of high virus loads and for development of AIDS
29. Role of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaques
30. Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells
31. Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys
32. Infection of monkeys with a chimeric HIV-1/SIVmac virus that expresses the HIV-1 envelope glycoproteins
33. Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis
34. Rhesus macaques that become systemically infected with pathogenic SHIV 89.6-PD after intravenous, rectal, or vaginal inoculation and fail to make an antiviral antibody response rapidly develop AIDS
35. Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway
36. Activation of NFAT-dependent gene expression by Nef: Conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta
37. Chronology of genetic changes in the vpu, env, and nef genes of chimeric simian-human immunodeficiency virus (strain HXB2) during acquisition of virulence for pig-tailed macaques
38. A molecular clone of simian-human immunodeficiency virus (Deltav-puSHIV(KU-1bMC33)) with a truncated, non-membrane-bound vpu results in rapid CD4(+) T cell loss and neuro-AIDS in pig-tailed macaques
39. Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection
40. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
41. Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4
42. Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
43. Regulation of virus release by the macrophage-tropic human immunodeficiency virus type 1 AD8 isolate is redundant and can be controlled by either Vpu or Env
44. KU inoculated into immunized macaques caused infection, but virus burdens progressively declined with time
45. Initial characterization of viral sequences from a SHIV-inoculated pig-tailed macaque that developed AIDS
46. Simian-human immunodeficiency virus (SHIV) containing the nef/long terminal repeat region of the highly virulent SIVsmmPBj14 causes PBj-like activation of cultured resting peripheral blood mononuclear cells, but the chimera showed no increase in virulence
47. A cell-free stock of simian-human immunodeficiency virus that causes AIDS in pig-tailed macaques has a limited number of amino acid substitutions in both SIVmac and HIV-1 regions of the genome and has offered cytotropism
48. An algorithm for mapping positively selected members of quasispecies-type viruses
49. Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression
50. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and with matrix choice
51. The Nef protein of HIV-1 associates with rafts and primes T cells for activation
52. Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4
53. Protection by live, attenuated simian immunodeficiency virus against heterologous challenge
54. Vaccine protection by a triple deletion mutant of simian immunodeficiency virus
55. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy