Rhesus macaques that become systemically infected with pathogenic SHIV 89.6-PD after intravenous, rectal, or vaginal inoculation and fail to make an antiviral antibody response rapidly develop AIDS

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 19, Issue 1, 1998, Pages 6-18

  Lu, Yichen ^a   Pauza, C David ^b   Lu, Xusheng ^c   Montefiori, David C ^d   Miller, Christopher J ^c,e  

^a Novartis Vaccines and Diagnostics   (United States)

^b UNIVERSITY OF WISCONSIN   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Animal model; Pathogenic SHIV; Rectal infection; Vaccine challenge stock; Vaginal infection

Indexed keywords

CD4 ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; VIRUS ANTIBODY; VIRUS ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS; INOCULATION; LYMPHOCYTE COUNT; MALE; NONHUMAN; PRIORITY JOURNAL; RECTUM; RHESUS MONKEY; SEROCONVERSION; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE SUBPOPULATION; VAGINA; VEIN; VIRUS ATTENUATION; VIRUS ENVELOPE; VIRUS PATHOGENESIS; VIRUS TRANSMISSION; VIRUS VIRULENCE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; RNA VIRUSES; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0032169938     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199809010-00002     Document Type: Article

References (36)

1. Sutjipto S, Pedersen NC, Miller CJ, et al. Inactivated simian immunodeficiency virus vaccine failed to protect rhesus macaques from intravenous or genital mucosal infection but delayed disease in intravenously exposed animals. J Virol 1990;64:2290-7.
2. Sutjipto S, Pederson N, Gardner MB, et al. Immunization of rhesus macaques with inactivated SIV does not protect against mucosal or iv challenge. In Groopman JE, Chen I, Essex M, Weiss R, eds. Human retroviruses New York: Alan R. Liss, 1990:271-81.
3. Miller CJ. Use of the SIV/rhesus macaque model of the heterosexual transmission of HIV in vaccine research. Vaccine Res 1992; 1:295-301.
4. Miller CJ, McGhee JR, Gardner MB. Mucosal immunity, HIV transmission and AIDS. Lab Invest 1992;68:129-45.
5. Marthas M, Sutjipto S, Miller C, et al. Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against intravenous and intravaginal challenge. In Brown F, Chanock RM, Ginsberg HS, Lerner RA, eds. Vaccines. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1992:117-22.
6. Miller CJ, Vogel P, Alexander NJ, Sutjipto S, Hendrickx AG, Marx PA. Localization of SIV in the genital tract of chronically infected female rhesus macaques. Am J Pathol 1992;141:655-60.
7. Lehner T, Wang Y, Cranage M, et al. Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunity SIV envelope and core vaccine in macaques. Nature Med 1996;2: 767-75.
8. Miller CJ, McChesney MB, Lü XS, et al. Rhesus macaques previously-infected with SHIV are protected from vaginal challenge with pathogenic SIVmac239. J Virol 1997;71:1911-21.
9. Shibata R, Sakai H, Kiyomasu T, Ishimoto A, Hayami M, Adachi A. Generation and characterization of infectious chimeric clones between human immunodeficiency virus type 1 and simian immunodeficiency virus from an African green monkey. J Virol 1990; 64:5861-8.
10. Shibata R, Kawamura M, Sakai H, Hayami M, Ishimoto A, Adachi A. Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells. J Virol 1991;65:3514-20.
11. Sakuragi S, Shibata R, Mukai R, et al. Infection of macaque monkeys with a chimeric human and simian immunodeficiency virus. J Gen Virol 1992;73:2983-7.
12. Li J, Lord CI, Haseltine W, Letvin NL, Sodroski J. Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus expressing the HIV-1 envelope glycoproteins. J Acquir Immune Defic Syndr 1992;5:639-46.
13. Lu Y, Brosio B, Lafaile M, et al. Vaginal transmission of chimeric simian/human immunodeficiency viruses in rhesus macaques. J Virol 1996;70:3045-50.
14. Trivedi P, Meyer KK, Streblow DN, Preuninger BL, Schultz KT, Pauza CD. Selective amplification of simian immunodeficiency virus genotypes after intrarectal inoculation of rhesus monkeys. J Virol 1994;68:7649-53.
15. Li J, Halloran M, Lord C, et al. Persistent infection of macaques with simian-human immunodeficiency viruses. J Virol 1995;69: 7061-71.
16. Luciw PA, Pratt-Lowe E, Shaw KES, Levy JA, Cheng-Mayer C. Persistent infection of rhesus macaques with T-cell-line-tropic and macrophage-tropic clones of simian/human immunodeficiency viruses (SHIV). Proc Natl Acad Sci USA 1995;92:7490-4.
17. Dunn CS, Beyer C, Kieny MP, et al. High viral load and CD4 lymphopenia in rhesus and cynomolgus macaques infected by a chimeric primate lentivirus constructed using the env, rev, tat, and vpu genes from HIV-1 Lai. Virology 1996;223:351-61.
18. Reimann KA, Li JT, Veazey R, et al. A chimeric simian/human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus monkeys. J Virol 1996;70: 6922-8.
19. + T cells, and AIDS. J Virol 1997;71:4016-23.
20. Reimann KA, Li JT, Voss G, et al. An env gene derived from a primary HIV-1 isolate confers high in vivo replicative capacity to a chimeric simian/human immunodeficiency virus in rhesus monkeys. J Virol 1996;70:1996.
21. Miller CJ, Marthas M, Torten J, et al. Intravaginal inoculation of rhesus macaques with cell-free simian immunodeficiency virus results in persistent or transient viremia. J Virol 1994;68:6391-6400.
22. Hoxie JA, Haggarty BS, Bonser SE, Rackowski JL, Shan H, Kanki PJ. Biological characterization of a simian immunodeficiency virus-like retrovirus (HTLV-IV): evidence for CD4-associated molecules required for infection. J Virol 1988;62:2557-68.
23. Lohman B, Higgins J, Marthas M, Marx P, Pedersen N. Development of simian immunodeficiency virus isolation, titration, and neutralization assays which use whole blood from rhesus monkeys and an antigen capture enzyme-linked immunosorbent assay. J Clin Microbiol 1991;29:2187-92.
24. Marthas ML, Ramos RA, Lohman BL, et al. Viral determinants of simian immunodeficiency (SIV) virulence in rhesus macaques assessed by using attenuated and pathogenic molecular clones of SIVmac. J Virol 1993;67:6047-55.
25. Montefiori D, Reiman K, Wyand M, et al. Neutralizing antibodies in sera from macaques infected with chimeric simian-human immunodeficiency virus containing the envelope glycoproteins of either a laboratory-adapted variant or a primary isolate of human immunodeficiency virus type 1. J Virol 1998;72:3427-31.
26. Kannagi M, Kiyotaki M, Desrosiers RC, et al. Humoral immune responses to T-cell tropic retrovirus simian T-lymphotropic virus type III in monkeys with experimentally induced acquired immune deficiency-like syndrome. J Clin Invest 1986;78:1229-36.
27. Daniel MD, Letvin NL, Sehgal PK, et al. Long-term persistent infection of macaque monkeys with the simian immunodeficiency virus. J Gen Virol 1987;68:3183-9.
28. Zhang J, Martin LN, Watson EA, et al. Simian immunodeficiency virus/delta-induced immunodeficiency disease in rhesus monkeys: relation of antibody response and antigenemia. J Infect Dis 1988; 158:1277-86.
29. Miller CJ, Alexander NJ, Sutjipto S, et al. Genital mucosal transmission of simian immunodeficiency virus: animal model for heterosexual transmission of human immunodeficiency virus. J Virol 1989;63:4277-84.
30. Otsyula MG, Miller CJ, Marthas ML, et al. Virus-induced immunosuppression is linked to rapidly fatal disease in infant rhesus macaques infected with simian immunodeficiency virus. Pediatr Res 1996;39:630-5.
31. Van Rompay KK, Otsyula MG, Marthas ML, Miller CJ, McChesney MB, Pedersen NC. Immediate zidovudine treatment protects simian immunodeficiency virus infected newborn macaques against rapid onset of AIDS. Antimicrob Agents Chemother 1995; 39:125-31.
32. + lymphocyte depletion in rhesus monkeys. J Virol 1997;71:4218-25.
33. Mellors JW, Rinaldo CRJ, Gupta P, RM W, Todd JA, Kingsley LA. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 1996;272:1167-70.
34. Hirsch VM, Fuerst TR, Sutler G, et al. Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara. J Virol 1996;70: 3741-52.
35. Lu Y, Salvato MS, Pauza CD, et al. Utility of SHIV for testing HIV-1 candidate vaccines in macaques. J Acquir Immune Defic Syndr Hum Retrovirol 1996;12:99-106.
36. Lu Y. HIV-1 vaccine candidate evaluation in non-human primates. Crit Rev Oncog 1997;8:273-91.