Desmosomal adhesion: Structural basis, molecular mechanism and regulation (review)

Molecular Membrane Biology

Volumn 19, Issue 2, 2002, Pages 81-94

  Garrod, David R ^a   Merritt, Anita J ^a   Nie, Zhuxiang ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Cell adhesion; Desmosome; Epithelium; Intercellular junction; Protein kinase C

Indexed keywords

CADHERIN; CELL ADHESION MOLECULE; DESMOCOLLIN; DESMOGLEIN; PROTEIN KINASE C;

ANIMAL CELL; AUTOIMMUNE DISEASE; BINDING AFFINITY; CELL ADHESION; CELL DIFFERENTIATION; CELL FUNCTION; CELL JUNCTION; CELL STRUCTURE; DESMOSOME; ENZYME REGULATION; EPIDERMIS; EPITHELIUM CELL; GENETIC DISORDER; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; TISSUE INTERACTION; ANIMAL; METABOLISM; PHYSIOLOGY;

ANIMAL; CADHERINS; CELL ADHESION; DESMOSOMES; HUMAN; SUPPORT, NON-U.S. GOV'T; ANIMALS; HUMANS;

ANIMALIA;

EID: 0035991944     PISSN: 09687688     EISSN: None     Source Type: Journal    
DOI: 10.1080/09687680210132476     Document Type: Review

References (123)

1. Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation
2. Extracellular domain of pemphigus vulgaris antigen (Desmoglein 3) mediates weak homophilic adhesion
3. Pemphigus vulgaris antigen (desmoglein 3) is localised in the lower epidermis, the site of blister formation in patients
4. The p120 catenin family: Complex roles in adhesion, signaling and cancer
5. Regulation of Rho GTPases by p120-catenin
6. Central role of the pakoglobin-binding domain for desmoglein 3 incorporation into desmosomes
7. p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells
8. Stratification-related expression of isoforms of the desmosomal cadherins in human epidermis
9. Mid-gestational lethality in mice lacking keratin 8
10. Linking colorectal cancer to Wnt signaling
11. The integration of cell adhesion with gene expression: The role of beta-catenin
12. Embryonic heart and skin defects in mice lacking plakoglobin
13. Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice
14. Identification of a cadherin cell adhesion recognition sequence
15. Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice: Inhibition or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions
16. Molecular diversity of plaques of epithelial-adhering junctions
17. Plakophilin 1 interferes with plakoglobin binding to desmoplakin yet together with plakoglobin promotes clustering of desmosome plaque complexes at cell-cell borders
18. The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion
19. Aspects of the structure and assembly of desmosomes
20. Structure and interactions of desmosomal and other cadherins
21. A central role for the Armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris
22. Tissue- and stratum-specific expression of the human involucrin promoter in transgenic mice
23. Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis
24. Transgenic mice expressing IFN-c in the epidermis have eczema, hair hypopigmentation, and hair loss
25. Multiple cadherin extracellular repeats mediate homophilic binding and adhesion
26. Plakoglobin suppresses epithelial proliferation and hair growth in vivo
27. Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation
28. Expression of full-length desmsomal glycoproteins (desmocollins) is not sufficient to confer strong adhesion in trarsfected L929 cells
29. 2+ dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollins, contributes to cell-cell adhesion
30. Cloning and sequence analysis of desmosomal glycoproteins 2 and 3 (desmocollins): Cadherin-like desmosomal adhesion molecules with heterogeneous cytoplasmic domains
31. A study of desmosomes in colorectal carcinoma
32. Transgenic expression of the human amphiregulin gene induces a psoriasislike phenotype
33. Continual assembly of half-desmosomal structures in the absence of cell contacts and their frustrated endocytosis: A coordinated Sisyphus cycle
34. The expression of desmoglein isoforms in cultured human keratinocytes is regulated by calcium, serum, and protein kinase C
35. Desmoglein isoform distribution affects stratum corneum structure and function
36. Elemental analysis mirrors epidermal differentiation
37. Rho-family GTPases in cadherin-mediated cell-cell adhesion
38. Rescuing desmoplakin function in extra-embryonic ectoderm reveals the importance of this protein in embryonic heart, neuroepithelium, skin and vasculature
39. Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage
40. Desmosomes and hemidesmosomes
41. Desmosomes: Differentiation, development, dynamics and disease
42. Desmosomal adhesion
43. Are desmosomes more than tethers for intermediate filaments?
44. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice
45. Deconstructing desmoplakin
46. The armadillo family of structural proteins
47. The function of plakophilin 1 in desmosome assembly and actin filament organization
48. Transgenic misexpression of the differentiation-specific desmocollin isoform 1 in basal keratinocytes
49. Calcium regulation of cell-cell contact and differentiation of epidermal cells in culture. An ultrastructural study
50. Clustered cadherin genes: A sequence-ready contig for the desmosomal cadherin locus on human chromosome 18
51. Assembly of desmsomal cadherins into desmosomes is isoform dependent
52. Identification of a basic protein of Mr 75,000 as an accessory desmosomal plaque protein in stratified and complex epithelia
53. Transmembrane signaling for adhesive regulation of desmosomes and hemidesmosomes, and for cell-cell detachment induced by pemphigus IgG in cultured keratinocytes: Involvement of protein kinase C
54. Desmosomal cadherins: Another growing multigene family of adhesion molecules
55. Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris
56. Identification of desmoglein, a constitutive desmosomal glycoproteins, as a member of the cadherin family of cell adhesion molecules
57. Analysis of desmosomal cadherin-adhesive function and stoichiometry of desmosomal cadherin-plakoglobin complexes
58. Desmosomes: Intercellular adhesive junctions specialized for attachment of intermediate filaments
59. The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes. Implications for cutaneous disease
60. From sticky zippers to morphology
61. The bovine desmocollin family: A new gene and expression patterns reflecting epithelial cell proliferation and differentiation
62. Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium
63. Cross-talk between adherens junctions and desmosomes depends on plakoglobin
64. Pemphigus vulgaris and pemphigus foliaceus antibodies are pathogenic in plasminogen activator knock-out mice
65. Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion
66. Plasticity in epithelial cell phenotype: Modulation by expression of different cadherin cell adhesion molecules
67. Mutual desmosome formation between all binary combinations of human, bovine, canine, avian and amphibian cells: Desmosome formation is not tissue- or species-specific
68. Splitting and internalization of the desmosomes of cultured kidney epithelial cells by reduction in calcium concentration
69. Development of desmosomal adhesion between MDCK cells following calcium switching
70. Recognition, calcium and the control of desmosome formation
71. Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome
72. Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease)
73. Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2
74. Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair
75. Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA
76. Structural basis of calcium-induced E-cadherin rigidification and dimerization
77. Inhibition of adhesion and induction of epithelial cell invasion by HAV-containing E-cadhein-specific peptides
78. Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma
79. Molecular map of the desmosomal plaque
80. Distinct desmocollin isoforms occur in the same desmosomes and show reciprocally graded distributions in bovine nasal epidermis
81. Localization of specificity determining sites in cadherin cell adhesion molecules
82. p120(ctn) binds to the membrane proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity
83. Solution structure of the epithelial cadherin domain responsible for selective cell adhesion
84. Experimental manipulation of desmosome formation
85. Regulation of desmosome assembly in epithelial cells: Kinetics of synthesis, transport, and stabilization of desmoglein I, a major protein of the membrane core domain
86. Structure and assembly of desmosome junctions: Biosynthesis and turnover of the major desmosome components of MadinDarby canine kidney cells in low calcium medium
87. 2+ dependence and mutational analysis reveal molecular details of E-cadherin homo-association
88. Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding
89. Structure of DSG1, the bovine desmosomal cadherin gene encoding the pemphigus foliaceous antigen. Evidence of polymorphism
90. Ultrastructure of desmosomes in mammalian intercalated disc; appearances after lanthanum treatment
91. Intracellular domain of desmoglein3 (pemphigus vulgaris antigen) confers adhesive function on the extracellular domain of E-cadherin without binding catenins
92. Targeting gene expression to the epidermis of transgenic mice: Potential applications to genetic skin disorders
93. The plakin family: Versatile organizers of cytoskeletal architecture
94. Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart
95. Desmosomal adhesion regulates epithelial morphogenesis and cell positioning
96. Structural basis of cell-cell adhesion by cadherins
97. Wnt signalling: A theme with nuclear variations
98. Role of cell adhesion-associated protein, pinin (DRS/memA), in corneal epithelial migration
99. Pemphigus vulgaris and pemphigus foliaceus sera show an inversely graded binding pattern to extra-cellular regions of desmosomes in different layers of human epidermis
100. Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains
101. Direct measurements of multiple adhesive alignments and unbinding trajectories between cadherin extracellular domains
102. Changes to desmosomal antigens and lectin-binding sites during differentiation in normal human epidermis: A quantitative ultrastructural study
103. Defining the interaction between intermediate filaments and desmosomes
104. Cadherins and catenins, Wnts and SOXs: Embryonic patterning in Xenopus
105. Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks
106. Experimental specification of cell sorting tissue spreading and specific spatial patterning by quantitative differences in cadherin expression
107. Structure-function analysis of cell adhesion by neural (N-) cadherin
108. The differential fate of cadherins during T-cell-induced keratinocyte apoptosis leads to spongiosis in eczematous dermatitis
109. Desmosomal adhesion inhibits invasive behaviour
110. Protein kinase C activation upregulates intercellular adhesion of alpha-catenin-negative human colon cancer cell variants via induction of desmosomes
111. Directed actin polymerization is the driving force for epithelial cell adhesion
112. Desmoplakin is essential in epidermal sheet formation
113. Transgenic mice provide new insights into the role of TGF-a during epidermal development and differentiation
114. The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells
115. Calcium-induced reorganization of desmosomal components in cultured human keratinocytes
116. The fate of desmosomal proteins in apoptotic cells
117. Regulation of keratinocyte intercellular junction organization and epidermal morphogenesis by E-cadherin
118. A novel family of cyclic peptide antagonists suggests that N-cadherin specificity is determined by amino acids that flank the HAV motif
119. INP, a novel N-cadherin antagonist targeted to the amino acids that flank the HAV motif
120. Protection against pemphigus foliaceus by desmoglein 3 in neonates
121. Characterisation of a desmocollin isoform (bovine DSC3) exclusively expressed in lower layers of stratified epithelia
122. Plakoglobin and beta-catenin: Protein interactions, regulation and biological roles
123. Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin