Multiple cadherin extracellular repeats mediate homophilic binding and adhesion

Journal of Cell Biology

Volumn 154, Issue 1, 2001, Pages 231-243

  Chappuis Flament, Sophie ^a   Wong, Ellen ^a   Hicks, Les D ^b   Kay, Cyril M ^b   Gumbiner, Barry M ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Adhesion; C cadherin; Dimerization; Homophilic binding; Structure

Indexed keywords

C CADHERIN; CADHERIN; DIMER; MONOMER; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CIS ISOMER; CONTROLLED STUDY; DELETION MUTANT; DIMERIZATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

ANIMALS; CADHERINS; CELL ADHESION; CHO CELLS; CRICETINAE; DIMERIZATION; FLOW CYTOMETRY; KINETICS; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; TIME FACTORS; XENOPUS;

ANIMALIA;

EID: 0035833265     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200103143     Document Type: Article

References (57)

1. Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic
2. Measurement of protein concentration with interference optics
3. Cadherin interaction probed by atomic force microscopy
4. Are changes in integrin affinity and conformation overemphasized?
5. Mutations of the human E-cadherin (CDH1) gene
6. Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas
7. Identification of a cadherin cell adhesion recognition sequence
8. Lateral dimerization is required for the homophilic binding activity of C-cadherin
9. Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation
10. Neural cell adhesion molecule: Structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing
11. High level expression in Chinese hamster ovary cells of soluble forms of CD4 T lymphocyte glycoprotein including glycosylation variants
12. Divalent cation regulation of the function of the leukocyte integrin LFA-1
13. Neuron-glia cell adhesion molecule interacts with neurons and astroglia via different binding mechanisms
14. Evidence for the binding of Ng-CAM to laminin
15. Cell adhesion: The molecular basis of tissue architecture and morphogenesis
16. Engineering hybrid genes without the use of restriction enzymes: Gene splicing by overlap extension
17. Cell-cell interactions in early embryogenesis: A molecular approach to the role of calcium
18. Analysis of data from the analytical ultracentrifuge by non-linear least-squares techniques
19. N-Cadherin extracellular repeat 4 mediates epithelial to mesenchymal transition and increased motility
20. Mutation analysis of cadherin-4 reveals amino acid residues of EC1 important for the structure and function
21. Homophilic adhesion by cadherins
22. Immobilized dimers of N-cadherin-Fc chimera mimic cadherin-mediated cell contact formation: Contribution of both outside-in and inside-out signals
23. Modern applications of analytical ultracentrifugation
24. Computer-aided interpretation of analytical sedimentation data for proteins
25. Disruption ofgastrulation movements in Xenopus by a dominant-negative mutant for C-cadherin
26. Selective disruption of E-cadherin function in early Xenopus embryos by a dominant negative mutant
27. Structural basis of calcium-induced E-cadherin rigidification and dimerization
28. Expressed recombinant cadherins mediate cell sorting in model systems
29. Localization of specificity determining sites in cadherin cell adhesion molecules
30. Correct proteolytic cleavage is required for the cell adhesive function of uvomorulin
31. 2+ binding site of uvomorulin abolish the adhesive function
32. A possible new adhesive site in the cell-adhesion molecule uvomorulin
33. 2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation
34. Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding
35. Homophilic adhesion mediated by the neural cell adhesion molecule involves multiple immunoglobulin domains
36. Analysis of neurocan structures interacting with the neural cell adhesion molecule N-CAM
37. The adhesive binding site of cadherins revisited
38. Functional cis-heterodimers of N- and R-cadherins
39. Structural biology of cadherins in the nervous system
40. Structural basis of cell-cell adhesion by cadherins
41. Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin
42. Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins
43. Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains
44. Direct measurements of multiple adhesive alignments and unbinding trajectories between cadherin extracellular domains
45. Cadherins and their connections: Adhesion junctions have broader functions
46. Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression
47. Regulation of leukocyte integrin function: Affinity vs. avidity
48. E-cadherin functions as a cis-dimer at the cell-cell adhesive interface in vivo
49. Cadhetin cell adhesion receptors as a morphogenetic regulator
50. Morphogenetic roles of classical cadherins
51. Structure-function analysis of cell adhesion by neural (N-) cadherin
52. Homophilic adhesion of E-cadherin occurs by a co-operative two-step interaction of N-terminal domains
53. Formation of heterotypic adherens-type junctions between L-CAM-containing liver cells and A-CAM-containing lens cells
54. A novel family of cyclic peptide antagonists suggests that N-cadherin specificity is determined by amino acids that flank the HAV motif
55. Lateral clustering of the adhesive ectodomain: A fundamental determinant of cadherin function
56. Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding
57. Analysis of C-cadherin regulation during tissue morphogenesis with an activating antibody