Glutathione depletion is associated with augmenting a pro-inflammatory signal: Evidence for an antioxidant/pro-oxidant mechanism regulating cytokines in the alveolar epithelium

Cytokines, Cellular and Molecular Therapy

Volumn 6, Issue 4, 2000, Pages 177-187

  Haddad, J J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Antioxidant; Chemioxyexcitation; Cytokines; Glutathione disequilibrium; Pharmacotherapy; Reactive oxygen species; Redox thiol regulation

Indexed keywords

ANTIOXIDANT; BACTERIUM LIPOPOLYSACCHARIDE; BUTHIONINE SULFOXIMINE; CYTOKINE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HYDROXYL RADICAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; ELECTROPHORESIS; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FETUS; INFLAMMATION; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS EPITHELIUM; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; WESTERN BLOTTING;

EID: 0034431511     PISSN: 13684736     EISSN: None     Source Type: Journal    
DOI: 10.1080/mccm.6.4.177.187     Document Type: Article

References (44)

1. Cellular oxygen sensors
2. Role of redox potential and reactive oxygen species in stress signaling
3. Oxygen sensing and the molecular adaptation to hypoxia
4. Regulation of gene expression by reactive oxygen
5. Multiple nuclear factors interact with the immunoglobulin enhancer sequences
6. Nuclear factor kappa B: An oxidative stress-responsive transcription factor of eukaryotic cells
7. Modulation of transcription factor NF-κB binding activity by oxidation-reduction in vitro
8. Antioxidant/pro-oxidant equilibrium regulates HIF-1α and NF-κB redox sensitivity: Evidence for inhibition by glutathione oxidation in alveolar epithelial cells
9. Functions of glutathione and glutathione disulfide in immunology and immunopathology
10. Glutathione and glutathione-dependent enzymes represent a coordinately regulated defense against oxidative stress
11. Glutathione-ascorbic acid anti-oxidant system in animals
12. 2-evoked regulation of HIF-1α and NF-κB in perinatal lung epithelium requires glutathione biosynthesis
13. Glutathione synthetic activity in the lungs in newborn guinea pigs
14. 2 cells exposed to oxidative stress or glutathione depletion
15. Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract in idiopathic pulmonary fibrosis
16. Oxidized glutathione is increased in the alveolar fluid of patients with the adult respiratory distress syndrome
17. Bronchopulmonary dysplasia and oxidative stress: Are we closer to an understanding of the pathogenesis of BPD?
18. Systemic deficiency of glutathione in cystic fibrosis
19. Mechanism of action of glutathione-dependent enzymes
20. The antioxidant enzymes glutathione peroxidase and catalase increase following traumatic brain injury in the rat
21. 2/ROS) dependent release of IL-1β, 1L-6 and TNF-α: Evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium
22. Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin
23. Effect of hyperoxia on human macrophage cytokine response
24. Association between oxidative stress and cytokine production in nickel-treated rats
25. Modulation of IL-1-induced chemokine expression in human mesangial cells through alterations in redox status
26. Thiols decrease human interleukin (IL)-4 production and IL-4-induced immunoglobulin synthesis
27. Thiol regulation of the production of TNF-α, IL-6 and IL-8 by human alveolar macrophages
28. Thiol regulation of endotoxin-induced release of tumor necrosis factor α from isolated rat Kupffer cells
29. Antioxidant treatment attenuates cytokine and chemokine levels in murine macrophages following silica exposure
30. Treatment with glutathione precursor decreases cytokine activity
31. Suppressive effects of intracellular glutathione on hydroxyl radical production induced by tumor necrosis factor
32. Thiol regulation of pro-inflammatory cytokines reveals a novel immunopharmacological potential of glutathione in the alveolar epithelium
33. Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader
34. Human granulocyte generation of hydroxyl radical
35. 193-195 receptor antagonism in the alveolar epithelium
36. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)
37. Immunological functions of the pulmonary epithelium
38. Differential regulation of interleukin-10 (IL-10) and IL-12 by glucocorticoids in vitro
39. Inosine inhibits inflammatory, cytokine production by a post-transcriptional mechanism and protects against endotoxin-induced shock
40. Suppression of IL-12 production by phosphodiesterase inhibition in murine endotoxemia is IL-10 independent
41. Phosphodiesterase 4 inhibitors as novel anti-inflammatory agents
42. Effect of adrenoreceptors on endotoxin-induced cytokines and lipid peroxidation in lung explants
43. Reactive oxygen intermediates stimulate interleukin-6 production in human bronchial epithelial cells
44. IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation