L-buthionine-(S,R)-sulfoximine, an irreversible inhibitor of γ-glutamylcysteine synthetase, augments LPS-mediated proinflammatory cytokine biosynthesis: Evidence for the implication of an IκB-α/NF-κB insensitive pathway

European Cytokine Network

Volumn 12, Issue 4, 2001, Pages 614-624

  Haddad, John J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Antioxidant; Chemioxyexcitation; Cytokines; Glutathione disequilibrium; Pharmacotherapy; Reactive oxygen species; Redox thiol regulation

Indexed keywords

BUTHIONINE SULFOXIMINE; CYTOKINE; GLUTAMATE CYSTEINE LIGASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; FETUS; LUNG ALVEOLUS EPITHELIUM; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; BUTHIONINE SULFOXIMINE; DNA PROBES; DNA-BINDING PROTEINS; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUTAMATE-CYSTEINE LIGASE; I-KAPPA B PROTEINS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; NF-KAPPA B; PREGNANCY; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0035680575     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Oxidant injury to the alveolar epithelium: Biochemical and pharmacologic studies
2. - evoked regulation of HIF-1 α and NF-κB in perinatal lung epithelium requires glutathione biosynthesis
3. Antioxidant/pro-oxidant equilibrium regulates HIF-1 α and NF-κB redox sensitivity. Evidence for inhibition by glutathione oxidation in alveolar epithelial cells
4. 2/ROS)-dependent release of IL-1β, IL-6 and TNF-α. Evidence of cytokines as oxygen sensitive mediators in the alveolar epithelium
5. Thiol regulation of pro-inflammatory cytokines reveals a novel immunopharmacological potential of glutathione in the alveolar epithelium
6. Alveolar type II cell apoptosis
7. Resistance of the alveolar epithelium to injury from septic shock in sheep
8. Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury
9. Targeting the alveolar epithelium in acute lung injury: Keratinocyte growth factor and regulation of the alveolar epithelial barrier
10. Interleukin-8 mediates injury from smoke inhalation to both the lung endothelial and the alveolar epithelial barriers in rabbits
11. Pro-inflammatory cytokines
12. Clinical pharmacology of cytokines
13. Cytokines in inflammation
14. Role of cytokines in rheumatoid arthritis
15. Interleukin-10 as an anti-stress cytokine
16. Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock
17. Adenosine cyclic AMP pathways and cytokine expression
18. Suppression of IL-12 production by phosphordiesterase inhibition in murine endotoxemia is IL-10 independent
19. Phosphodiesterase 4 inhibitors as novel anti-inflammatory agents
20. Differential regulation of interleukin-10 (IL-10) and IL-12 by glucocorticoids in vitro
21. A novel anti-rheumatic drug suppresses tumor necrosis factor-α and augments interleukin-10 in adjuvant arthritic rats
22. The biphasic immunoregulation of pyrimidylpiperazine (Y-40138) is IL-10 sensitive and requires NF-κB targeting in the alveolar epithelium
23. Effect of adrenoreceptors on endotoxin-induced cytokines and lipid peroxidation in lung explants
24. Mitogen-activated protein kinase cascades and regulation of gene expression
25. Organization and regulation of mitogen-activated protein kinase signaling pathways
26. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
27. Glutathione metabolism and its selective modification
28. Inflammation and the regulation of glutathione level in lung epithelial cells
29. Regulation of nuclear factor-κB, activator protein-1, and glutathione levels by tumor necrosis factor-α and dexamethasone in alveolar epithelial cells
30. Modulation of IL-1-induced chemokine expression in human mesangial cells through alterations in redox status
31. Thiols decrease human interleukin (IL)-4 production and IL-4-induced immunoglobulin synthesis
32. Thiol regulation of the production of TNF-α, IL-6 and IL-8 by human alveolar macrophages
33. Thiol regulation of endotoxin-induced release of tumor necrosis factor α from isolated rat Kupffer cells
34. N-acetylcysteine inhibits IL-1 α-induced IL-8 secretion by human bronchial epithelial cells
35. Antioxidants inhibit the in vitro production of inflammatory cytokines in Crohn's disease and ulcerative colitis
36. Antioxidant treatment attenuates cytokine and chemokine levels in murine macrophages following silica exposure
37. 193-195 receptor antagonism in the alveolar epithelium
38. Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract in idiopathic pulmonary fibrosis
39. 2 cells exposed to oxidative stress or glutathione depletion
40. Oxidized glutathione is increased in the alveolar fluid of patients with the adult respiratory distress syndrome
41. Bronchopulmonary dysplasia and oxidative stress: Are we closer to an understanding of the pathogenesis of BPD?
42. Systemic deficiency of glutathione in cystic fibrosis
43. Association between oxidative stress and cytokine production in nickel-treated rats
44. Effect of hyperoxia on human macrophage cytokine response
45. Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin
46. Over-expression of γ-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1
47. Role of redox potential and reactive oxygen species in stress signaling
48. Immunopharmacology: Anti-inflammatory therapy targeting transcription factors
49. Redox signaling and the emerging therapeutic potential of thiol antioxidants
50. Nuclear factor-κB: An oxidative stress-responsive transcription factor of eukaryotic cells
51. Separation of oxidant-initiated and redox-regulated steps in the NF-κB signal transduction pathway
52. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB