Hypersulfated Low Molecular Weight Heparin with Reduced Affinity for Antithrombin Acts as an Anticoagulant by Inhibiting Intrinsic Tenase and Prothrombinase

Journal of Biological Chemistry

Volumn 276, Issue 13, 2001, Pages 9755-9761

  Anderson, Julia A M ^a,c   Fredenburgh, James C ^a   Stafford, Alan R ^a   Guo, Y Steven ^b,d   Hirsh, Jack ^a   Ghazarossian, Vartan ^b,e   Weitz, Jeffrey I ^a,f  

^a MCMASTER UNIVERSITY   (Canada)

^b Vascular Therapeutics Inc   (United States)

^c ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^d Neoparin Inc   (United States)

^e Imetrx Inc   (United States)

^f HAMILTON HEALTH SCIENCES   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOLOGICAL MATERIALS; COAGULATION; MOLECULAR WEIGHT; PHOSPHOLIPIDS; SULFONATION;

ANTICOAGULANTS;

ENZYMES;

ANTICOAGULANT AGENT; ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; BLOOD CLOTTING FACTOR 8A; BUFFER; ENOXAPARIN; HEPARIN COFACTOR II; INTRINSIC TENASE; LOW MOLECULAR WEIGHT HEPARIN; PHOSPHOLIPID; UNCLASSIFIED DRUG; CANCER PROCOAGULANT; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; GLYCOSAMINOGLYCAN; HEPARIN; PERIODATE; PERIODIC ACID; SULFUR; THROMBOPLASTIN; TUMOR PROTEIN;

ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; BLOOD CLOTTING TIME; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; PRIORITY JOURNAL; SULFATION; BINDING SITE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; IC 50; KINETICS; METABOLISM; PARTIAL THROMBOPLASTIN TIME; PROTEIN BINDING; TIME;

VILLA;

ANTICOAGULANTS; ANTITHROMBINS; BINDING SITES; BLOOD COAGULATION; BUFFERS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR XA; GLYCOSAMINOGLYCANS; HEPARIN; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; NEOPLASM PROTEINS; PARTIAL THROMBOPLASTIN TIME; PERIODIC ACID; PHOSPHOLIPIDS; PROTEIN BINDING; SULFUR; THROMBOPLASTIN; TIME FACTORS;

EID: 0035971113     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010048200     Document Type: Article

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