Multiple endocytic signals in the C-terminal tail of the cystic fibrosis transmembrane conductance regulator

Biochemical Journal

Volumn 354, Issue 3, 2001, Pages 561-572

  Hu, W ^a   Howard, M ^a   Lukacs, G L ^a  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

Author keywords

Clathrin coated vesicle; Internalization; Surface density

Indexed keywords

BIOASSAY; BIOSYNTHESIS; CELLS; MEMBRANES;

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CTFR); ENDOCYTIC SIGNALS;

MUTAGENESIS;

CHLORIDE CHANNEL; CYCLIC AMP; INTERLEUKIN 2 RECEPTOR; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CHIMERA; CYSTIC FIBROSIS; ENDOCYTOSIS; ENDOSOME; ENZYME LOCALIZATION; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CHLORIDES; CLATHRIN-COATED VESICLES; COS CELLS; CRICETINAE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ENDOCYTOSIS; ION TRANSPORT; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, INTERLEUKIN-2; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; TRANSFECTION;

ANIMALIA; CHIMAERA; CHIMAERIFORMES;

EID: 0035868361     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3540561     Document Type: Article

References (58)

1. Identification of the cystic fibrosis gene: Genetic analysis
2. The cystic fibrosis transmembrane conductance regulator
3. Structure and function of the CFTR chloride channel
4. CFTR is a conductance regulator as well as a chloride channel
5. Abnormal subcellular localization of mutated CFTR protein in a cystic fibrosis epithelial cell line
6. Subcellular localization of CFTR to endosomes in a ductal epithelium
7. Functional CFTR in endosomal compartment of CFTR-expressing fibroblasts and T84 cells
8. The cystic fibrosis transmembrane regulator is present and functional in endosomes. Role as a determinant of endosomal pH
9. Characterization of the internalization pathways for the cystic fibrosis transmembrane conductance regulator
10. Constitutive internalization of cystic fibrosis transmembrane conductance regulator occurs via clathrin-dependent endocytosis and is regulated by protein phosphorylation
11. Biochemical and biophysical identification of cystic fibrosis transmembrane conductance regulator chloride channels as components of endocytic clathrin-coated vesicles
12. Epitope tagging permits cell surface detection of functional CFTR
13. Forskolin-induced apical membrane insertion of virally-expressed, epitope-tagged CFTR in polarized MDCK cells
14. 2+ or microfilaments
15. Vasoactive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, Squalus acanthias. Acute regulation of CFTR trafficking in an intact epithelium
16. Protein sorting by tyrosine-based signals: Adapting to the Ys and wherefores
17. Endocytosis and molecular sorting
18. Targeting of membrane proteins to endosomes and lysosomes
19. Signal-dependent membrane protein trafficking in the endocytic pathway
20. The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesicles
21. Common signals control low density lipoprotein receptor sorting in endosomes and the Golgi complex of MDCK cells
22. Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site
23. Characteristics of the tyrosine recognition signal for internalization of transmembrane surface glycoproteins
24. Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes
25. Interaction of tyrosine-based sorting signals with clathrin-associated proteins
26. A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains
27. An LI and ML motif in the cytoplasmic tail of the MHC-associated invariant chain mediate rapid internalization
28. The amino terminus of GLUT4 functions as an internalization motif but not an intracellular retention signal when substituted for the transferrin receptor cytoplasmic domain
29. The carboxyl terminus of GLUT4 contains a serine-leucine-leucine sequence that functions as a potent internalization motif in Chinese hamster ovary cells
30. A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist mediated beta-2 adrenergic receptor sequestration
31. A tyrosine-based signal targets H/K-ATPase to a regulated compartment and is required for the cessation of gastric acid secretion
32. Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator requires a tyrosine-based signal
33. The carboxyl terminus of the cystic fibrosis transmembrane conductance regulator binds to AP-2 clathrin adaptors
34. A peptide sequence confers retention and rapid degradation in the endoplasmic reticulum
35. Site-directed mutagenesis of double-stranded DNA by the polymerase chain reaction
36. 'Megaprimer' method of PCR: Increased template concentration improves yield
37. - channel in CHO cells stably expressing the cystic fibrosis gene
38. Calcium phosphate-mediated gene transfer: A highly efficient transfection system for stably transforming cells with plasmid DNA
39. Metabolic instability of plasmid DNA in the cytosol: A potential barrier to gene transfer
40. Human transferrin receptor internalization is partially dependent upon an aromatic amino acid on the cytoplasmic domain
41. Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts
42. Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors
43. The cytoplasmic tail of rhodopsin acts as a novel apical sorting signal in polarized MBCK cells
44. Hm1 muscarinic cholinergic receptor internalization requires a domain in the third cytoplasmic loop
45. Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
46. Both the alpha and beta chains of high-affinity interleukin 2 receptors are located in intracellular vesicles when their ligand is endocytosed
47. Endocytosis of interleukin 2 receptors in human T lymphocytes: Distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains
48. Localization of TGN38 to the trans-Golgi network: Involvement of a cytoplasmic tyrosine-containing sequence
49. A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments
50. An endocytosed TGN38 chimeric protein is delivered to the TGN after trafficking through the endocytic recycling compartment in CHO cells
51. Effects of hypertonic sucrose and potassium depletion on the binding properties of beta and alpha 1 adrenergic receptors measured on intact cells
52. Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis
53. Protein translocation across membranes
54. Proper sorting of the cation-dependent mannose 6-phosphate receptor in endosomes depends on a pair of aromatic amino acids in its cytoplasmic tail
55. GLUT-4 NH2 terminus contains a phenylalanine-based targeting motif that regulates intracellular sequestration
56. Cation-dependent mannose 6-phosphate receptor contains two internalization signals in its cytoplasmic domain
57. Structure-activity relationship of the leucine-based sorting motifs in the cytosolic tail of the major histocompatibility complex-associated invariant chain
58. Topogenic signals in integral membrane proteins