Intravitreal adenoviral gene transfer evokes an immune response in the retina that is directed against the heterologous lacZ transgene product but does not limit transgene expression

Brain Research

Volumn 892, Issue 2, 2001, Pages 229-240

  Isenmann, Stefan ^a   Engel, Stefan ^a   Kügler, Sebastian ^a   Gravel, Claude ^b   Weller, Michael ^a   Bähr, Mathias ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b CENTRE DE RECHERCHE DE L INSTITUT UNIVERSITAIRE EN SANTÉ MENTALE DE QUÉBEC   (Canada)

Author keywords

BDNF; CNS; CNTF; GDNF; Gene therapy; Immune response; Neurotrophin 3; Optic system

Indexed keywords

BETA GALACTOSIDASE; BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HUMAN GROWTH HORMONE; T LYMPHOCYTE ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; GENE EXPRESSION; GENE TRANSFER; HUMAN; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; INFLAMMATION; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA CELL; T LYMPHOCYTE; TRANSGENE;

ADENOVIRIDAE; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL COUNT; CILIARY NEUROTROPHIC FACTOR; GENE EXPRESSION; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LAC OPERON; LYMPHOCYTES; MACROPHAGES; MICROGLIA; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEUROTROPHIN 3; RATS; RETINA; TRANSGENES; VITREOUS BODY;

EID: 0035936954     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02957-7     Document Type: Article

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