Atropisomeric quinazolin-4-one derivatives are potent noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 2, 2001, Pages 177-181

  Welch, W M ^a   Ewing, F E ^a   Huang, J ^a   Menniti, F S ^a   Pagnozzi, M J ^a   Kelly, K ^a   Seymour, P A ^a   Guanowsky, V ^a   Guhan, S ^a   Guinn, M R ^a   Critchett, D ^a   Lazzaro, J ^a   Ganong, A H ^a   DeVries, K M ^a   Staigers, T L ^a   Chenard, B L ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 6 (1 IMIDAZOLYL) 7 NITRO 2,3 QUINOXALINEDIONE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR ANTAGONIST; ANTICONVULSIVE AGENT; PIRIQUALONE; QUINAZOLINE DERIVATIVE; TALAMPANEL; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; DERIVATIZATION; DRUG POTENCY; ISOMERISM; RECEPTOR AFFINITY; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; SYNAPTIC TRANSMISSION;

ANIMALS; ANTICONVULSANTS; BINDING, COMPETITIVE; BRAIN; CALCIUM; DISEASE MODELS, ANIMAL; INHIBITORY CONCENTRATION 50; ISOMERISM; NEUROMUSCULAR BLOCKING AGENTS; PROTEIN BINDING; PYRIDINES; QUINAZOLINES; QUINAZOLINONES; RATS; RECEPTORS, AMPA; SEIZURES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTIC TRANSMISSION;

EID: 0035931552     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00622-3     Document Type: Article

References (44)