Novel AMPA receptor antagonists: Synthesis and structure-activity relationships of 1-hydroxy-7-(1H-imidazol-1-yl)-6-nitro-2,3(1H,4H)- quinoxalinedione and related compounds

Journal of Medicinal Chemistry

Volumn 39, Issue 20, 1996, Pages 3971-3979

  Ohmori, J ^a   Shimizu Sasamata, M ^a   Okada, M ^a   Sakamoto, S ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 QUINOXALINEDIONE DERIVATIVE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; DRUG CARRIER; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; QUISQUALIC ACID RECEPTOR ANTAGONIST; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NEUROPROTECTION; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BRAIN; EXCITATORY AMINO ACID ANTAGONISTS; HYDROXYLATION; IMIDAZOLES; MOLECULAR STRUCTURE; QUINOXALINES; RATS; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM;

EID: 0029841643     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960387+     Document Type: Article

References (0)