YM872, a novel selective α-amino-3-hydroxy-5-methylisoxazole-4- propionic acid receptor antagonist, reduces brain damage after permanent focal cerebral ischemia in cats

Journal of Pharmacology and Experimental Therapeutics

Volumn 284, Issue 2, 1998, Pages 467-473

  Takahashi, Masayasu ^a   Ni, Jian Wei ^a   Kawasaki Yatsugi, Sachiko ^a   Toya, Takashi ^a   Yatsugi, Sin Ichi ^a   Shimizu Sasamata, Masao ^a   Koshiya, Kazuo ^a   Shishikura, Jun Ichi ^a   Sakamoto, Shuichi ^a   Yamaguchi, Tokio ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

[2,3 DIOXO 7 (1H IMIDAZOL 1 YL) 6 NITRO 1,2,3,4 TETRAHYDRO 1 QUINOXALINYL] ACETIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; CAT; CONTROLLED STUDY; DRUG BLOOD LEVEL; ELECTROENCEPHALOGRAM; HEMISPHERE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; STROKE;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CATS; CEREBRAL CORTEX; CORPUS STRIATUM; IMIDAZOLES; MALE; NEUROPROTECTIVE AGENTS; QUINOXALINES; RECEPTORS, AMPA; REGIONAL BLOOD FLOW;

EID: 15444343987     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Bannan PE, Graham DI, Lees KR and McCulloch J (1994) Neuroprotective effect of remacemide hydrochloride in focal cerebral ischemia in the cat. Brain Res 664: 271-275.
2. Baron BM, Harrison BL, McDonald IA, Meldrum BS, Palfreyman MG, Salituro FG, Siegel BW, Slone AL, Turner JP and White HS (1992) Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther 262:947-956.
3. Berkelbach van der Sprenkel JW and Tulleken CAF (1988) The postorbital approach to the middle cerebral artery in cats. Stroke 19:503-506.
4. Bose B, Osterholm J and Berry R (1984) A reproducible experimental model of focal cerebral ischemia in the cat. Brain Res 311:385-391.
5. Buchan AM, Slivka A and Xue D (1992) The effect of the NMDA receptor antagonist MK-801 on cerebral blood flow and infarct volume in experimental focal stroke. Brain Res 574:171-177.
6. Bullock R, Graham DI, Chen MH, Lowe D and McCulloch J (1990) Focal cerebral ischaemia in the cat: pretreatment with a competitive NMDA antagonist, D-CPPene. J Cereb Blood Flow Metab 10:668-674.
7. Bullock R, Graham DI, Swanson S and McCulloch J (1994) Neuroprotective effect of the AMPA receptor antagonist LY-293558 in focal cerebral ischemia in the cat. J Cereb Blood Flow Metab 14:466-471.
8. Burchuladze R and Rose SPR (1992) Memory formation in day-old chicks requires NMDA but not non-NMDA glutamate receptors. Eur J Neurosci 4:533-538.
9. Busto R, Dietrich WD, Globus MYT and Ginsberg MD (1989) Post-ischemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury. Neurosci Lett 101:299-304.
10. Chapman AG, Smith SE and Meldrum BS (1991) The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI52466, in mice. Epilepsy Res 9:92-96.
11. Dorman PJ, Counsell CE and Sandercock PAG (1996) Recently developed neuroprotective therapies for acute stroke: A qualitative systematic review of clinical trials. CNS Drugs 5(6):457-474.
12. Gill R, Brazell C, Woodruff GN and Kemp JA (1991) The neuroprotective action of Dizocilpine (MK-801) in the rat middle cerebral artery occlusion model of focal ischaemia. Br J Pharmacol 103:2030-2036.
13. Gill R, Nordholm L and Lodge D (1992) The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) in a rat focal ischaemia model. Brain Res 580:35-43.
14. Gill R (1994) The pharmacology of -amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate antagonists and their role in cerebral ischemia. Cerebrovasc Brain Metab Rev 6:225-256.
15. Ginsberg MD and Busto R (1989) Rodent models of cerebral ischemia. Stroke 20: 1627-1642.
16. Graham SH, Chen J, Lan JQ and Simon RP (1996) A dose-response study of neuroprotection using the AMPA antagonist NBQX in rat focal cerebral ischemia. J Pharmacol Exp Ther 276:1-4.
17. 2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition. Science 252: 851-853.
18. Izumisawa N, Kawakami A, Ohata T, Hanada T and Okeda R (1995) YM90K, an AMPA antagonist, has no neurotoxic effects on cerebrocortical neurons in rats. Exp Neurol 134:199-204.
19. Karpiak SE, Tagliavia A and Wakade CG (1989) Animal models for the study of drugs in ischemic stroke. Annu Rev Pharmacol Toxicol 29:403-414.
20. Koek W, Woods JH and Winger GD (1988) MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys. J Pharmacol Exp Ther 245:969-974.
21. Kohara A, Okada M, Ohno K, Sakamoto S, Shishikura J, Inami H, Shimizu-Sasamata M and Yamaguchi T (1996) In vitro characterization of YM872: A selective, potent and highly water-soluble AMPA receptor antagonist. Soc Neurosci Abstr 22:1528.
22. Kuroiwa T, Bonnekoh P and Hossmann KA (1990) Prevention of postischemic hypothermia prevents ischemic injury of CA1 neurons in gerbils. J Cereb Blood Flow Metab 10:550-556.
23. Lees GJ (1996) Therapeutic potential of AMPA receptor ligands in neurological disorders. CNS Drugs 5(1):51-74.
24. Li HB, Matsumoto K, Tohda M, Yamamoto M and Watanabe H (1996) NMDA-but not AMPA-receptor antagonists augment scopolamine-induced spatial cognitive deficit of rats in a radial maze task. Brain Res 725:268-271.
25. Meldrum BS, Croucher MJ, Czuczwar SJ, Collins JF, Curry K, Joseph M and Stone TW (1983) A comparison of the anticonvulsant potency of (±)-2-amino-5-phosphonopentanoic acid and 2-amino-7-phosphonoheptanoic acid. Neuroscience 9:925-930.
26. 2+ homeostasis. Prog Neurobiol 37:255-285.
27. Morris RGM, Anderson E, Lynch GS and Baudry M (1986) Selective impairment of learning and blockade of long-term potentiation by N-methyl-D-aspartate receptor antagonist, AP5. Nature 319:774-776.
28. Nurse S and Corbett D (1993) Dose hypothermia contribute to the neuroprotective actions of NBQX? Soc Neurosci Abstr 19:683.3.
29. Nurse S and Corbett D (1996) Neuroprotection after several days of mild, drug-induced hypothermia. J Cereb Blood Flow Metab 16:474-480.
30. O'Brien MD and Waltz AG (1973) Transorbital approach for occluding the middle cerebral artery without craniectomy. Stroke 4:201-206.
31. Olney JW, Labruyere J and Price MT (1989) Pathological changes induced in cerebrocortical neurones by phencyclidine and related drugs. Science 244:1360-1362.
32. Olney JW, Labruyere J, Wang G, Wozniak DF, Price MT and Sesma MA (1991) NMDA antagonist neurotoxicity: mechanism and prevention. Science 254:1515-1518.
33. Ozyurt E, Graham DI, Woodruff GN and McCulloch J (1988) Protective effect of the glutamate antagonist, MK-801 in focal cerebral ischemia in the cat. J Cereb Blood Flow Metab 8:138-143.
34. Parada J, Czuczwar SJ and Turski WA (1992) NBQX dose not affect learning and memory tasks in mice: A comparison with D-CPPene and ifenprodil. Cognit Brain Res 1:67-71.
35. Park CK, Nehls DG, Graham DI, Teasdale GM and McCulloch J (1988a) Focal cerebral ischaemia in the cat: treatment with the glutamate antagonist MK-801 after induction of ischaemia. J Cereb Blood Flow Metab 8:757-762.
36. Park CK, Nehls DG, Graham DI, Teasdale GM and McCulloch J (1988b) The glutamate antagonist MK-801 reduces focal cerebral ischemic brain damage in the rat. Ann Neurol 24:543-554.
37. Patel TR, Galbraith SL, McAuley MA, Doherty AM, Graham DI and McCulloch J (1995) Therapeutic potential of endothelin receptor antagonists in experimental stroke. J Cardiouasc Pharmacol 26:suppl. 3, S412-S415.
38. Patel TR, Galbraith S, Graham DI, Hallak H, Doherty AM and McCulloch J (1996) Endothelin receptor antagonist increases cerebral perfusion and reduces ischaemic damage in feline focal cerebral ischaemia. J Cereb Blood Flow Metab 16:950-958.
39. Shimizu-Sasamata M, Kawasaki-Yatsugi S, Okada M, Sakamoto S, Yatsugi S, Togami J, Hatanaka K, Ohmori J, Koshiya K, Usuda S and Murase K (1996) YM90K: Pharmacological characterization as a selective and potent -amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist. J Pharmacol Exp Ther 276:84-92.
40. Siesjö BK (1981) Cell damage in the brain: a speculative synthesis. J Cereb Blood Flow Metab 1:155-185.
41. Siesjö BK and Bengtsson F (1989) Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: A unifying hypothesis. J Cereb Blood Flow Metab 9:127-140.
42. Snider RS and Niemer A (1961) Stereotaxic Atlas for the Cat Brain. University of Chicago Press, Chicago.
43. Uematsu D, Greenberg JH, Reivich M and Hickey WF (1989a) Direct evidence for calcium-induced ischemic and reperfusion injury. Ann Neurol 26:280-283.
44. Uematsu D, Greenberg JH, Hickey WF and Reivich M (1989b) Nimodipine attenuates both increase in cytosolic free calcium and histologic damage following focal cerebral ischemia and reperfusion in cats. Stroke 20:1531-1537.
45. Uematsu D, Araki N, Greenberg JH, Sladky J and Reivich M (1991) Combined therapy with MK-801 and nimodipine for protection of ischemic brain damage. Neurology 41:88-94.
46. Verdoorn TA, Burnashev N, Monyer H, Seeburg PH and Sakmann B (1991) Structural determinants of ion flow through recombinant glutamate receptor channels. Science 252:1715-1718.
47. Watkins JC, Krogsgaard-Larsen P and Honoré T (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and antagonists. Trends Pharmacol Sci 11:25-33.
48. Welsh FA, Smith RE and Harris VA (1990) Mild hypothermia prevents ischemic injury in gerbil hippocampus. J Cereb Blood Flow Metab 10:557-563.
49. Wong LA and Kemp JA (1991) Sites for antagonism on the N-methyl-D-aspartate receptor channel complex. Annu Rev Pharmacol Toxicol 31:401-425.
50. Xue D, Huang Z-G, Smith KE and Buchan AM (1992) Immediate or delayed mild hypothermia prevents focal cerebral infarction. Brain Res 587:66-72.
51. Xue D, Huang ZG, Barnes K, Lesiuk HJ, Smith KE and Buchan AM (1994) Delayed treatment with AMPA, but not NMDA, antagonists reduces neocortical infarction. J Cereb Blood Flow Metab 14:251-261.
52. Yatsugi S, Takahashi M, Kawasaki-Yatsugi S, Koshiya K, Sakamoto S, Uematsu D and Shimizu-Sasamata M (1996) Neuroprotective effect of YM90K, a novel AMPA/ kainate receptor antagonist, in focal cerebral ischemia in cats. J Cereb Blood Flow Metab 16:959-966.