The Cyclin-dependent Kinases cdk2 and cdk5 Act by a Random, Anticooperative Kinetic Mechanism

Journal of Biological Chemistry

Volumn 276, Issue 51, 2001, Pages 48292-48299

  Clare, Paula M ^a   Poorman, Roger A ^a   Kelley, Laura C ^a   Watenpaugh, Keith D ^a   Bannow, Carol A ^a   Leach, Karen L ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DISEASES; ENZYME KINETICS; ONCOLOGY;

ANTICOOPERATIVE KINETIC MECHANISM;

ENZYMES;

ADENOSINE TRIPHOSPHATE; AMINOPYRIDINE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 5; PEPTIDE; PHOSPHATE; PNU 112455A; THREONINE; UNCLASSIFIED DRUG; VALINE; CDK2 PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASES; CYCLIN-DEPENDENT KINASE 5; ENZYME INHIBITOR; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASES; PYRIMIDINE DERIVATIVE; SULFONAMIDE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; INSECT; KINETICS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; AMINO ACID SEQUENCE; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION;

ANIMALIA; INSECTA;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; KINETICS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; SUBSTRATE SPECIFICITY; SULFONAMIDES;

EID: 0035930519     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102034200     Document Type: Article

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