Competitive inhibition of MAP kinase activation by a peptide representing the α(c) helix of ERK

Biochemistry

Volumn 37, Issue 25, 1998, Pages 8879-8885

  Horiuchi, Kurumi Y ^a   Scherle, Peggy A ^a   Trzaskos, James M ^a   Copeland, Robert A ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; BINDING, COMPETITIVE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CATALYSIS; ENZYME INHIBITORS; HUMANS; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN KINASES; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY;

EID: 0032560594     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972731q     Document Type: Article

References (26)

1. Goldsmith, E. J., and Cobb, M. H. (1994) Curr. Opin. Struct. Biol. 4, 833-840.
2. Zhang, F., Strand, A., Robbins, D., Cobb, M. H., and Goldsmith, E. J. (1994) Nature 367, 704-711.
3. Anderson, N. G., Maller, J. L., Tonks, N. K., and Sturgill, T. W. (1990) Nature 343, 651-653.
4. Brunet, A., and Pouysse'gur, J. (1996) Science 272, 1652-1655.
5. Mansour, S. J., Candia, J. M., Matsuura, J. E., Manning, M. C., and Ahn, N. G. (1996) Biochemistry 35, 15529-15536.
6. Robinson, M. J., Cheng, M., Khokhlatchev, A., Eben, D., Ahn, N., Guan, K.-L., Stein, B., Goldsmith, E., and Cobb, M. H. (1996) J. Biol. Chem. 271, 29734-29739.
7. Boulton, T. G., Nye, S. H., Robbins, D. J., Ip, N. Y., Radziejewska, E., Morgenbesser, S. D., DePinho, R. A., Panayotatos, N., Cobb, M. H., and Yancopoulos, G. D. (1991) Cell 65, 663-675.
8. Kneller, D. G., Cohen, F. E., and Langridge, R. (1990) J. Mol. Biol. 214, 171-182.
9. Yang, J. T., Wu, C.-S. C., and Martinez, H. M. (1986) Methods Enzymol. 130, 208-269.
10. Nakajima, T., Yasuhara, T., Uzu, S., Wakamatsu, K., Miyazawa, T., Fukuda, K., and Tsukamoto, Y. (1985) Peptides 6, 425-430.
11. Copeland, R. A. (1996) Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis, pp 93-119, Wiley-VCH, New York.
12. Copeland, R. A. (1994) Methods for Protein Analysis: A Practical Guide to Laboratory Protocols, pp 191-197, Chapman & Hall, New York.
13. Clore, G. M., Bax, A., Ikura, M., and Gronenborn, A. M. (1993) Curr. Opin. Struct. Biol. 3, 838-845.
14. Menger, F. M. (1992) Biochemists 31, 5368-5373.
15. Seger, R., Ahn, N. G., Posada, J., Munar, E. S., Jensen, A. M., Cooper, J. A., Cobb, M. H., and Krebs, E. G. (1992) J. Biol. Chem. 267, 14373-14381.
16. Zhang, J., Zhang, F., Ebert, D., Cobb, M. H., and Goldsmith, E. J. (1995) Structure (London) 3, 299-307.
17. Ferrell, J. E., and Bhatt, R. R. (1997) J. Biol. Chem. 272, 19008-19016.
18. Burack, W. R., and Sturgill, T. W. (1997) Biochemistry 36, 5929-5933.
19. Cook, P. F., Neville, M. E., Jr., Vrana, K. E., Hartl, T., and Roskoski, R., Jr. (1982) Biochemistry 21, 5794-5799.
20. Posner, I., Engel, M., and Levitzki, A. (1992) J. Biol. Chem. 267, 20638-20647.
21. Cole, P. A., Burn, P., Takacs, B., and Walsh, C. T. (1994) J. Biol. Chem. 269, 30880-30887.
22. Boener, R. J., Barker, S. C., and Knight, W. B. (1995) Biochemistry 34, 16419-16423.
23. LoGrasso, P. V., Frantz, B., Rolando, A. M., O'Keefe, S. J., Hermes, J. D., and O'Neill, E. A. (1997) Biochemistry 36, 10422-10427.
24. Cleland, W. W. (1979) Methods Enzymol. 63, 103-138.
25. Haystead, T. A. J., Dent, P., Wu. J., Haystead, C. M. M., and Sturgill, T. W. (1992) FEBS Lett. 306, 17-22.
26. Mansour, S. J., Candia, J. M., Matsuura, J. E., Manning, M. C., and Ahn, N. G. (1996) Biochemistry 35, 15529-15536.