Characterization and kinetic mechanism of catalytic domain of human vascular endothelial growth factor receptor-2 tyrosine kinase (VEGFR2 TK), a key enzyme in angiogenesis

Biochemistry

Volumn 37, Issue 47, 1998, Pages 16788-16801

  Parast, Camran V ^a   Mroczkowski, Barbara ^a   Pinko, Chris ^a   Misialek, Shawn ^a   Khambatta, Godrej ^a   Appelt, Krzysztof ^a  

^a AGOURON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE MAGNESIUM; BISPHOSPHONIC ACID DERIVATIVE; CADMIUM; LIGAND; MAGNESIUM ION; PEPTIDE; PHOSPHATE; PROTEIN TYROSINE KINASE; SYNTHETIC PEPTIDE; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; KINETICS; LEPIDOPTERA; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

ADENOSINE TRIPHOSPHATE; BINDING SITES; BINDING, COMPETITIVE; CADMIUM; CATALYSIS; ENZYME ACTIVATION; HUMANS; KINETICS; MAGNESIUM; MANGANESE; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SUBSTRATE SPECIFICITY; TIME FACTORS;

ANIMALIA; LEPIDOPTERA; UNIDENTIFIED BACULOVIRUS;

EID: 0032564322     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi981291f     Document Type: Article

References (42)

1. Folkman, J., and Shing, Y. (1992) J. Biol. Chem. 267, 10931-10934.
2. Eckhadt, S. G., and Pluda, J. M. (1997) Invest. New Drugs 15, 1-3.
3. O'Reilly, M. S. (1997) Invest. New Drugs 15, 5-13.
4. Terman, B. I., Dougher-Vermazen, M., Carrion, M. E., Dimitrov, D., Armellino, D. C., Gospodarowicz, D., and Bohlen, P. (1992) Biochem. Biophys. Res. Commun. 187, 1579-1586.
5. Nguyen, M. (1997) Invest. New Drugs 15, 29-37.
6. Wei, L., Hubbard, S. R., Hendrickson, W. A., and Ellis, L. (1995) J. Biol. Chem. 270, 8122-8130.
7. Cobb, M. H., Sang, B.-C., Gonzalez, R., Goldsmith, E., and Ellis, L. (1989) J. Biol. Chem. 264, 18701-18706.
8. Ullrich, A., and Schlessinger, J. (1990) Cell 61, 203-212.
9. Mohammadi, M., Schlessinger, J., and Hubbard, S. R. (1996) Cell 86, 577-587.
10. Cleland, W. W. (1979) Methods Enzymol. 63, 103.
11. Doughter-Vermazen, M., Hulmes, J. D., Bohlen, P., and Terman, B. I. (1994) Biochem. Biophys. Res. Commun. 205, 728-738.
12. Villafranca, J. J., and Nowak, T. (1992) The Enzymes XX, 63-94.
13. McClure, W. R., Lardy, H. A., and Kneifel, H. P. (1971) J. Biol. Chem. 246, 3569-3578.
14. Infante, J. P., and Kinsella, J. E. (1976) Int. J. Biochem. 7, 483-496.
15. Dawson, R. M. C., Elliott, D. C., Elliott, W. H., and Jones, K. M. (1986) Data for Biochemical Research, 3rd ed., Oxford Science Publications, pp 399-415.
16. Thomas, K. A. (1996) J. Biol. Chem. 271, 603-606.
17. Pawson, T. (1995) Nature 373, 573-580.
18. Frattali, A. L., Treadway, J. L., and Pessin, J. E. (1992) J. Biol. Chem. 267, 19521-19528.
19. Jaye, M., Schlessinger, J., and Dionne, C. (1992) Biochim. Biophys. Acta 1135, 185-199.
20. Iwasaki, Y., Nishiyama, H., Suzuki, K., and Koizumi, S. (1997) Biochemistry 36, 2694-2700.
21. Kohanski, R. A. (1993) Biochemistry 32, 5773-5780.
22. Mohammadi, M., Dikic, I., Sorokin, A., Burgess, W. H., Jaye, M., and Schlessinger, J. (1996) Mol. Cell. Biol. 16, 977-989.
23. Wilden, P. A., Kahn, C. R., Siddle, K., and White, M. F. (1992) J. Biol. Chem. 267, 16660-16668.
24. Johnson, L. N., Noble, M. E. M., and Owen, D. J. (1996) Cell 85, 149-158.
25. Cleland, W. W. (1982) Methods Enzymol. 87, 159-179.
26. Boerner, R. J., Barker, S. C., and Knight, W. B. (1995) Biochemistry 34, 16419-16423.
27. Cole, P. A., Burns, P., Takacs, B., and Walsh, C. T. (1994) J. Biol. Chem. 269, 30880-30887.
28. Grace, M. R., Walsh, C. T., and Cole, P. A. (1997) Biochemistry 36, 1874-1881.
29. Walker, D. H., Kuppuswamy, D., Visvanathan, A., and Pike, L. (1987) Biochemistry 26, 1428-1433.
30. Wong, T. W., and Goldberg, A. R. (1984) J. Biol. Chem. 259, 3127-3131.
31. Posner, I., Engel, M., and Levitski, A. (1992) J. Biol. Chem. 267, 20638-20647.
32. Erneux, C., Cohen, S., and Garbers, D. L. (1983) J. Biol. Chem. 258, 4137-4142.
33. Cook, P. F., Neville, M. E., Jr., Vrana, K. E., Hartle, T., and Roskoski, R., Jr. (1982) Biochemistry 21, 5794-5799.
34. Whitehouse, S., and Walsh, D. A. (1983) J. Biol. Chem. 258, 3682-3692.
35. Whitehouse, S., Feramisco, J. R., Casnellie, J. E., Krebs, E. G., and Walsh, D. A. (1983) J. Biol. Chem. 258, 3693-3701.
36. LaGrasso, P. V., Frantz, B., Ronaldo, A. M., O'Keefe, S. J., Hermes, J. D., and O'Neil, E. A. (1987) Biochemistry 36, 10422-10427.
37. Armstrong, R. N., Kondo, H., Granot, J., Kaiser, E. T., and Mildvan, A. S. (1979) Biochemistry 18, 1230-1238.
38. Bossemeyer, D., Engh, R. A., Kinzel, V., Ponstingl, H., and Hubber, R. (1993) EMBO J. 12, 849-859.
39. Zheng, J., Trafny, E. A., Knighton, D. R., Xuong, N. H., Taylor, S. S., Ten Eyck, L. F., and Sowadski, J. M. (1993) Acta Crystallogr., Sect. D 49, 362-365.
40. Hubbard, S. R., Wei, L., Ellis, L., and Hendrickson, W. A. (1994) Nature 372, 746-754.
41. Grant, B. D., and Adams, J. A. (1996) Biochemistry 35, 2022-2029.
42. Sun, G., and Budde, R. J. A. (1997) Biochemistry 36, 2139-2146.