A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the β-phosphate to destabilize GDP on ARF1

EMBO Journal

Volumn 17, Issue 13, 1998, Pages 3651-3659

  Béraud Dufour, Sophie ^a   Robineau, Sylviane ^a   Chardin, Pierre ^a   Paris, Sonia ^a   Chabre, Marc ^a   Cherfils, Jacqueline ^b   Antonny, Bruno ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

Author keywords

ARF; ARNO; G protein; Guanine nucleotide exchange factor; Sec7 domain

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE DIPHOSPHATE; MAGNESIUM ION;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE MUTATION; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS;

ADP-RIBOSYLATION FACTOR 1; ADP-RIBOSYLATION FACTORS; ASPARTIC ACID; BINDING SITES; FUNGAL PROTEINS; GLUTAMIC ACID; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE DIPHOSPHATE; MAGNESIUM; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHOSPHATES; PROTEIN CONFORMATION;

EID: 0039818755     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.13.3651     Document Type: Article

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