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Volumn 66, Issue 8, 2001, Pages 2789-2801

Synthesis of novel 3′-C-methylene thymidine and 5-methyluridine/cytidine H-phosphonates and phosphonamidites for new backbone modification of oligonucleotides

(6) An, H a,b Wang, T a Maier, M A a Manoharan, M a Ross, B S a Cook, P D a

a ISIS PHARMACEUTICALS (United States)

b Valeant Pharmaceuticals International (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARBUZOV REACTIONS;

CHEMICAL BONDS; CHEMICAL MODIFICATION; ENZYMES; MONOMERS; RNA; SYNTHESIS (CHEMICAL);

OLIGOMERS;

3' C IODOMETHYL 5 METHYLCYTIDINE; 3' C METHYLENE THYMIDINE; 3' DEOXY 3' C [[(2 CYANOETHOXY)PHOSPHINYL]METHYL] 5' O (4 METHOXYTRITYL) 2' O METHYL 4 N(N METHYLPYRROLIDIN 2 YLENE) 5 METHYLCYTIDINE; 3' DEOXY 3' C [[(2 CYANOETHOXY)PHOSPHINYL]METHYL] 5' O (4 METHOXYTRITYL) 2' O METHYL 5 METHYLURIDINE; 3' DEOXY 3' C [[(2 CYANOETHOXY)PHOSPHINYL]METHYL] 5' O (4 METHOXYTRITYL)THYMIDINE; 5 METHYLCYTIDINE H PHOSPHONATE DERIVATIVE; 5 METHYLURIDINE H PHOSPHONATE DERIVATIVE; CYTIDINE DERIVATIVE; MONOMER; NUCLEASE; NUCLEOSIDE DERIVATIVE; OLIGONUCLEOTIDE; PHOSPHONIC ACID DERIVATIVE; RNA; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CHEMICAL BOND; CHEMICAL MODIFICATION; CHEMICAL REACTION; DRUG SYNTHESIS; RNA BINDING;

ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; CYTIDINE; OLIGONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHONIC ACIDS; THYMIDINE; URIDINE;

EID: 0035917376 PISSN: 00223263 EISSN: None Source Type: Journal
DOI: 10.1021/jo001699u Document Type: Article

Times cited : (48)

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