An efficient multigram synthesis of monomers for the preparation of novel oligonucleotides containing isosteric non-phosphorous backbones

Nucleosides and Nucleotides

Volumn 16, Issue 7-9, 1997, Pages 1629-1632

  Dimock, Stuart ^a   Bhat, Balkrishen ^a   Peoc'h, Didier ^a   Sanghvi, Yogesh S ^a   Swayze, Eric E ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDE DERIVATIVE; OLIGONUCLEOTIDE;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; CANCER; CONFERENCE PAPER; DRUG STRUCTURE; DRUG SYNTHESIS; OLIGOMERIZATION; RNA SEQUENCE; VIRUS INFECTION;

EID: 0030732309     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319708006242     Document Type: Conference Paper

References (9)

1. Sanghvi, Y. S.; Cook, P. D. In Nucleosides and Nucleotides as Antitumor and Antiviral Agents, Chu, C. K., Baker, D. C., Eds.; Plenum Press: New York, 1993; pp 311-324, and reference cited therein.
2. (a) Morvan, F.; Sanghvi, Y. S.; Perbost, M.; Vasseur, J.-J.; Bellon, L. J. Amer. Chem. Soc. 1996, 118, 255-256.
3. (b) Sanghvi, Y. S.; Bellon, L.; Morvan, P.; Hoshiko, T.; Swayze, E.; Cummins, L.; Frier, S.; Dean, N.; Monia, B.; Griffey, R.; Cook, P. D.; Nucleosides Nucleotides 1995, 16, 1087-1090.
4. Peoc'h, D.; Swayze, E. E.; Bhat, B.; Dimock, S.; Sanghvi, Y. S. Nucleosides Nucleotides, in press 1997.
5. Bhat, B.; Swayze, E. E.; Wheeler, P.; Dimock, S.; Perbost, M.; Sanghvi, Y. S. J. Org. Chem., in press 1996.
6. (a) Sanghvi, Y. S.; Bharadwaj, R.; Debart, F.; De Mesmaeker, A. Synthesis 1994, 1163-1166.
7. (b) Sanghvi, Y. S.; Ross, B.; Bharadwaj, R.; Vasseur, J.-J. Tetrahedron Lett. 1994, 35, 4697-4700.
8. Perbost, M.; Hoshiko, T.; Morvan, P.; Swayze, E.; Griffey, R. H.; Sanghvi, Y. S. J. Org. Chem., 1995, 60, 5150-5156.
9. McBride, L. J.; Kierzek, R.; Beaucage, S. L.; Caruthers, M. H. J. Amer. Chem. Soc., 1986, 108, 2040-2048.