Antitumor effect of monoclonal antibody-carboplatin conjugates in nude mice bearing human ovarian cancer cells

International Journal of Clinical Oncology

Volumn 4, Issue 4, 1999, Pages 236-240

  Ota, Yoriko ^a   Fukasawa, Ichio ^a   Tokita, Hisashi ^b   Yamaguchi, Tomohisa ^a   Yoshino, Haruo ^a   Endo, Keigo ^c   Inaba, Noriyuki ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b Chiba Prefecture Cancer Center   (Japan)

^c GUNMA UNIVERSITY   (Japan)

Author keywords

Carboplatin; Cytokeratin 8; Human ovarian cancer; Immunotargeting; Nude mice

Indexed keywords

ANTIBODY CONJUGATE; CARBOPLATIN; CYTOKERATIN; IODINE 125; MONOCLONAL ANTIBODY; PLATINUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BODY WEIGHT; CANCER CHEMOTHERAPY; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; OVARY CANCER; PRIORITY JOURNAL; RADIOACTIVITY; TUMOR VOLUME;

EID: 0032835568     PISSN: 13419625     EISSN: None     Source Type: Journal    
DOI: 10.1007/s101470050060     Document Type: Article

References (14)

1. Ehrlich P (1900) On immunity with special reference to cell life. Proc Soc Lond 66:424-448
2. Koelwe G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predifined specificity. Nature 256:495-497
3. Levy R, Hurwitz E, Maron R, et al. (1975) The specific cytotoxic effects of daunomycin-conjugated to antitumor antibodies. Cancer Res 35:1182-1186
4. Tsukada Y, Hurwitz E, Kashi R, et al. (1982) Chemotherapy by intravenous administration of conjugates of daunomycin with monoclonal and conventional anti-rat alphafetoprotein antibodies. Proc Natl Acad Sci USA 79:7896-7901
5. Takada S, Hirata H, Imai K (1993) Fundamental study on cancer therapy by monoclonal antibody-anti-cancer agent (adriamycin) conjugate. Drug Delivery System 8:103-109
6. Konno H, Tadakuma T, Kumai K (1990) The antitumor effects of adriamycin entrapped in liposomes on lymph node metastases. Jpn J Surg 20:424-428
7. Schechter B, Wilchek M, Arnon R (1987) Selective cytotoxicity against tumor cells by cisplatin complexed to antitumor antibodies via carboxymethyl dextran. Cancer Immunol Immunother 25:225-230
8. Yamaguchi T, Tsurumi H, Kitamura, Takahashi T (1993) Production, binding and cytotoxicity of human/mouse chimeric monoclonal antibody-neocarzinostatin conjugate. Jpn J Cancer Res 84: 1190-1194
9. Paganelli G, Magnani P, Fazio F (1992) Monoclonal antibody pretargeting techniques; the avidin-biotin system in clinical oncology. In: Epenetos AA (ed) Monoclonal antibody 2; applications in clinical oncology. Chapman and Hall Medical, London, pp 171-178
10. Chung JK, Kang SB, Lee HP, et al. (1993) Clinical immunoscintigraphy of ovarian carcinoma using iodine-131-labeled 145-9 monoclonal antibody. J Nucl Med 34:1651-1655
11. Schultes BC, Spaniol S, Popat S, et al. (1992) Strategies for selective treatment of ovarian cancer; antibody-targeted photodynamic therapy. In: Epenetos AA (ed) Monoclonal antibody 2; applications in clinical oncology. Chapman and Hall Medical, London, pp 321-329
12. Letocha H, Nilsson S, Silen A, et al. (1993) Immunotargeting of human urothelial cancer with monoclonal cytokeratin antibodies. Acta Oncol 32:793-800
13. Schechter B, Pauzner R, Wilchek M, Arnon R (1986) Cis-platinum (II) complexes of carboxymethyl dextran as potential antitumor agents. II. In vitro and in vivo activity. Cancer Biochem Biophys 8:289-298
14. Schechter B, Arnon R, Wilchek M, et al. (1991) Indirect immunotargeting of cis-Pt to human epidermoid carcinoma KB using the avidin-biotin system. Int J Cancer 48:167-172