Synthesis and HPLC analysis of enzymatically cleavable linker consisting of poly(ethylene glycol) and dipeptide for the development of immunoconjugate

Journal of Controlled Release

Volumn 69, Issue 1, 2000, Pages 27-41

  Suzawa, Toshiyuki ^a   Nagamura, Satoru ^a   Saito, Hiromitsu ^a   Ohta, So ^a   Hanai, Nobuo ^a   Yamasaki, Motoo ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Duocarmycin; Enzymatic release; Immunoconjugate; PEG dipeptidyl linker

Indexed keywords

ANTIBODY CONJUGATE; DUOCARMYCIN B1; MACROGOL; PEPTIDE;

ARTICLE; DRUG CONJUGATION; DRUG RELEASE; DRUG STABILITY; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; TEMPERATURE;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; DIPEPTIDES; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOCONJUGATES; MAGNETIC RESONANCE SPECTROSCOPY; POLYETHYLENE GLYCOLS; PYRROLIDINONES;

EID: 0034601910     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(00)00282-0     Document Type: Article

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