jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans

EMBO Journal

Volumn 20, Issue 18, 2001, Pages 5114-5128

  Villanueva, Alberto ^a   Lozano, José ^a   Morales, Albert ^a   Lin, Xinhua ^a   Deng, Xinzhu ^a   Hengartner, Michael O ^b   Kolesnick, Richard N ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

Body movement; Caenorhabditis elegans; Heavy metals; jkk 1; mek 1

Indexed keywords

C JUN N TERMINAL KINASE 1 ALPHA; C JUN N TERMINAL KINASE 1 BETA; CADMIUM; COPPER; HEAVY METAL; JKK 1; MEK 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MKK 4; MKK 7; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BODY MOVEMENT; CAENORHABDITIS ELEGANS; DROSOPHILA; EGG LAYING; HYPERSENSITIVITY; LOCOMOTION; MOTOR COORDINATION; NONHUMAN; PRIORITY JOURNAL; WORM;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BEHAVIOR, ANIMAL; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELLS, CULTURED; GAMMA-AMINOBUTYRIC ACID; HELMINTH PROTEINS; LOCOMOTION; MAP KINASE KINASE 1; METALS, HEAVY; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RNA, HELMINTH; SEQUENCE HOMOLOGY, AMINO ACID; STRESS;

EID: 0035903537     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.18.5114     Document Type: Article

References (62)

1. The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor
2. Odorant-selective genes and neurons mediate olfaction
3. Presence of the Caenorhabditis elegans spliced leader on different mRNAs and in different genera of nematodes
4. The genetics of Caenorhabditis elegans
5. Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation
6. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
7. Olfactory recognition and discrimination in Caenorhabditis elegans
8. JNK1 is required for T cell-mediated immunity against Leishmania major infection
9. Transforming G protein-coupled receptors potently activate JNK (SAPK). Evidence for a divergence from the tyrosine kinase signaling pathway
10. Osmotic avoidance defective mutants of the nematode Caenorhabditis elegans
11. The mitogen-activated protein kinase signal transduction pathway
12. Signal transduction by the JNK group of MAP kinases
13. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
14. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
15. Defective T cell differentiation in the absence of Jnk1
16. JNK is required for effector T-cell function but not for T-cell activation
17. Coordinated transcriptional regulation of the unc-25 glutamic acid decarboxylase and the unc-47 GABA vesicular transporter by the Caenorhabditis elegans UNC-30 homeodomain protein
18. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
19. MEKK1/JNK signaling stabilizes and activates p53
20. An osmosensing signal transduction pathway in mammalian cells
21. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis
22. Hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement
23. A pheromone influences larval development in the nematode Caenorhabditis elegans
24. Transcription factor ATF2 regulation by the JNK signal transduction pathway
25. Selective interaction of JNK protein kinase isoforms with transcription factors
26. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
27. A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression
28. Synaptic code for sensory modalities revealed by C.elegans GLR-1 glutamate receptor
29. Distinct signaling pathways mediate touch and osmosensory responses in a polymodal sensory neuron
30. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
31. Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase
32. The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development
33. Structure, expression and evolution of a heat shock gene locus in Caenorhabditis elegans that is flanked by repetitive elements
34. A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans
35. A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons
36. A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses
37. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
38. Sounding the alarm: Protein kinase cascades activated by stress and inflammation
39. The stress-activated protein kinase subfamily of c-Jun kinases
40. Levamisole-resistant mutants of the nematode Caenorhabditis elegans appear to lack pharmacological acetylcholine receptors
41. Mechanosensory signalling in C.elegans mediated by the GLR-1 glutamate receptor
42. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
43. Genes required for GABA function in Caenorhabditis elegans
44. The GABAergic nervous system of Caenorhabditis elegans
45. Identification and characterization of the vesicular GABA transporter
46. DNA transformation
47. JNK signaling and morphogenesis in Drosophila
48. The protein kinases of Caenorhabditis elegans: A model for signal transduction in multicellular organisms
49. The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye
50. Mitogen-activated protein kinase pathways
51. A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila
52. Temporal and spatial expression patterns of the small heat shock (hsp16) genes in transgenic Caenorhabditis elegans
53. Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes
54. 2-terminal kinase
55. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
56. Disruption of the antiproliferative TGF-β signaling pathways in human pancreatic cancer cells
57. Chemotaxis by the nematode Caenorhabditis elegans: Identification of attractants and analysis of the response by use of mutants
58. The structure of the ventral nerve cord of Caenorhabditis elegans
59. Integration of MAP kinase signal transduction pathways at the serum response element
60. 2-terminal kinase activation and defects in AP-1 transcriptional activity
61. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
62. + T cells to Th1 cells requires MAP kinase JNK2