Distinct signaling pathways mediate touch and osmosensory responses in a polymodal sensory neuron

Journal of Neuroscience

Volumn 19, Issue 6, 1999, Pages 1952-1958

  Hart, Anne C ^a,b   Kass, Jamie ^c   Shapiro, Jonathan E ^b   Kaplan, Joshua M ^d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Caenorhabditis elegans; Degenerin; Eos 2; Eos 1; Mechanosensation; Neurodegeneration; OSM 10; Osmosensation

Indexed keywords

OCTANOL; VOLATILE AGENT;

ANIMAL EXPERIMENT; ARTICLE; CAENORHABDITIS ELEGANS; GENE EXPRESSION; GENE ISOLATION; GENE MAPPING; GENE MUTATION; HABITUATION; HYPEROSMOLARITY; MICROTUBULE; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE CELL; SENSORY STIMULATION; SIGNAL TRANSDUCTION; TACTILE DISCRIMINATION; TACTILE STIMULATION;

EID: 0033559456     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-06-01952.1999     Document Type: Article

References (36)

1. Albert PS, Brown SJ, Riddle DL (1981) Sensory control of dauer larva formation in C. elegans. J Comp Neurol 198:435-451.
2. Avery L, Horvitz H (1989) Effects of killing identified pharyngeal neurons on feeding behavior in Caenorhabditis elegans. Neuron 3:473-485.
3. Bargmann Cl, Thomas JH, Horvitz HR (1990) Chemosensory cell function in the behavior and development of Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol 55:529-538.
4. Brewster J, de Valoir T, Dwycr N, Winter E, Gustin M (1993) An osmosensing signal transduction pathway in yeast. Science 259:1760-1763.
5. Caterina M, Schumacher M, Tominaga M, Rosen T, Levine J, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816.
6. Chalfie M, Thomson JN (1979) Organization of neuronal microtubules in the nematode C. elegans. J Cell Biol 82:278-289.
7. Chalfie M, Driscoll M, Huang M (1993) Degenerin similarities. Nature 361:504.
8. Colbert H, Smith T, Bargmann C (1997) OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J Neurosci 17:8259-8269.
9. Culotti JG, Russell RL (1978) Osmotic avoidance defective mutants of the nematode Caenorhabditis elegans. Genetics 90:243-256.
10. Driscoll M, Chalfie M (1991) The mec-4 gene is a member of a family of C. elegans genes that can mutate to induce neuronal degeneration. Nature 349:588-593.
11. Driscoll M, Kaplan J (1997) Mechanotransduction. In: C. elegans II (Riddle D, Blumcnthal T, Meyer B, Priess J, eds), pp 645-677. Cold Spring Harbor, NY: Cold Spring Harbor.
12. Galcheva-Gargova Z, Derijard B, Wu I, Davis R (1994) An osmosensing signal transduction pathway in mammalian cells. Science 265:806-808.
13. Garcia-Anoveros J, Ma C, Chalfie M (1995) Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain. Curr Biol 5:441-448.
14. Gu G, Caldwell GA, Chalfie M (1996) Genetic interactions affecting touch sensitivity in Caenorhabditis elegans. Proc Natl Acad Sci USA 93:6577-6582.
15. Hallows K, Knauf P (1994) Principles of cell volume regulation. In: Cellular and molecular physiology of cell volume regulation (Strange K, ed), pp 3-29. Boca Raton, FL: CRC.
16. Hart A, Kramer H, Van Vactor D, Paidhunghat M, Zipursky SL 11990) Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments. Genes Dev 4:1835-1847.
17. Hart A, Sims S, Kaplan J (1995) A synaptic code for sensory modalities revealed by analysis of the C. elegans GLR-1 glutamate receptor. Nature 378:82-85.
18. Huang M, Chalfie M (1994) Gene interactions affecting mechanoscnsory transduction in C. elegans. Nature 367:467-470.
19. Kaplan JM, Horvitz HR (1993) A dual mechanosensory and chemosensory neuron in C. elegans. Proc Natl Acad Sci USA 90:2227-2231.
20. Kernan M, Zuker C (1995) Genetic approaches to mechanosensory transduction. Curr Opin Neurobiol 5:443-448.
21. Krapivinsky G, Ackerman M, Gordon E, Krapivinsky L. Clapham D (1994) Molecular characterization of a swelling-induced chloride conductance regulatory protein, pICIn. Cell 76:439-448.
22. Maeda T, Wurgler-Murphy S, Saito H (1994) A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369:242-245.
23. Maeda T, Takekawa M, Saito H (1995) Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science 269:554-558.
24. Maricq AV, Peckol E, Driscoll M, Bargmann C (1995) glr-1, a C. elegans glutamate receptor that mediates mechanosensory signaling. Nature 378:78-81.
25. Nonet M, Staunton J, Kilgard M, Fergestad T, Hartwieg E, Horvitz H, Jorgensen E, Meyer B (1997) Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles. J Neurosci 17:8061-8073.
26. Oliet S, Bourque C (1993) Mechanosensitive channels transduce osmosensitivity in supraoptic neurons. Nature 364:341-343.
27. Oliet S, Bourque C (1996) Gadolinium uncouples mechanical detection and osmoreceptor potential in supraoptic neurons. Neuron 16:175-181.
28. Perkins LA, Hedgecock EM, Thomson JN, Culotti JG (1986) Mutant sensory cilia in the nematode Caenorhabditis elegans. Dev Biol 117:456-487.
29. Posas F, Wurgler-Murphy S, Maeda T, Witten E, Thai T, Saito H (1996) Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor. Cell 86:865-875.
30. Strange K, Emma F, Jackson P (1996) Cellular and molecular physiology of volume-sensitive anion channels. Am J Physiol 270:C711-C730.
31. Sukharev S, Blount P, Martinac B, Kung C (1997) Mechanosensitive channels of Escherichia coli: the MscL gene, protein, and activities. Annu Rev Physiol 59:633-657.
32. Sulston JE, Schierenberg E, White JG, Thomson JN (1983) The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 100:64-119.
33. Tavernarakis N, Shreffler W, Wang S, Driscoll M (1997) unc-8, a DEG/ ENaC family member, encodes a subunit of a candidate mechanically gated channel that modulates C. elegans locomotion. Neuron 18:107-119.
34. Tilly B, Gaestel M, Engel K, Edixhoven M, de Jonge H (1996) Hypoosmotic cell swelling activates the p38 MAP kinase signalling cascade. FEBS Lett 385:133-136.
35. Troemel E, Chou H, Dwyer N, Colbert H, Bargmann C (1995) Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans. Cell 83:207-218.
36. White JG, Southgate E, Thomson JN, Brenner S (1986) The structure of the nervous system of Caenorhabditis elegans. Philos Trans R Soc Lond [Biol] 314:1-340.