The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor

Journal of Neuroscience

Volumn 19, Issue 13, 1999, Pages 5348-5359

  Bamber, Bruce A ^b   Beg, Asim A ^a   Twyman, Roy E ^a,c   Jorgensen, Erik M ^b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c Johnson Pharmaceutical Research Institute   (United States)

Author keywords

C. elegans; Coordinate regulation of subunit expression; GABA neurotransmission; GABA receptor; GABA receptor diversity; GABA receptor structure function; unc 49

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; GREEN FLUORESCENT PROTEIN; IONOTROPIC RECEPTOR; MESSENGER RNA;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA LIBRARY; DNA SEQUENCE; GABAERGIC SYSTEM; GENE STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR CLONING; NEUROMUSCULAR SYNAPSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SOUTHERN BLOTTING; XENOPUS;

EID: 0033169088     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-13-05348.1999     Document Type: Article

References (31)

1. Alfonso A, Grundahl K, McManus JR, Asbury JM, Rand JB (1994) Alternative splicing leads to two cholinergic proteins in Caenorhabditis elegans. J Mol Biol 241:627-630.
2. Amin J, Weiss DS (1994) Homomeric p1 GABA channels: activation properties and domains. Receptors Channels 2:227-236.
3. A receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital. Nature 366:565-569.
4. Andres AJ, Thummel CS (1994) Methods for quantitative analysis of transcription in larvae and prepupae. Methods Cell Biol 44:565-573.
5. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (1995) Current protocols in molecular biology. New York: Wiley.
6. Barstead RJ, Waterston RH (1989) The basal component of the nematode dense-body is vinculin. J Biol Chem 264:10177-10185.
7. Blumenthal T, Steward K (1997) RNA processing and gene structure. In: C. elegans II (Riddle DL, Blumenthal T, Meyer BJ, Priess JR, eds), pp 117-145. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
8. Bormann J, Rundstrom N, Betz H, Langosch D (1993) Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo-and hetero-oligomers. EMBO J 12:3729-3737.
9. Clark SG, Lu X, Horvitz HR (1994) The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins. Genetics 137:987-997.
10. Donevan SD, Beg A, Gunther JM, Twyman RE (1998) The methylglutamate, SYM 2081, is a potent and highly selective agonist at kainate receptors. J Pharmacol Exp Ther 285:539-545.
11. Feinberg AP, Vogelstein B (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132:6-13.
12. Galzi JL, Changeux JP (1994) Neurotransmitter-gated ion channels as unconventional allosteric proteins. Curr Opin Struct Biol 4:554-565.
13. Galzi JL, Devillers-Thiery A, Hussy N, Bertrand S, Changeux JP, Bertrand D (1992) Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic. Nature 359:500-505.
14. Laughton DL, Lunt GG, Wolstenholme AJ (1997) Alternative splicing of a Caenorhabditis elegans gene produces two novel inhibitory amino acid receptor subunits with identical ligand binding domains but different ion channels. Gene 201:119-125.
15. A receptor channels are dependent on α-subunit isoform. Biophys J 73:2518-2526.
16. A receptor channels. Annu Rev Neurosci 17:569-602.
17. A receptor. J Neurochem 61:375-377.
18. McIntire SL, Jorgensen E, Horvitz HR (1993a) Genes required for GABA function in Caenorhabditis elegans. Nature 364:334-337.
19. McIntire SL, Jorgensen E, Kaplan J, Horvitz HR (1993b) The GABAergic nervous system of Caenorhabditis elegans. Nature 364:337-341.
20. A receptor subtypes really occur in the brain? Trends Neurosci 19:139-143.
21. McKim KS, Matheson C, Marra MA, Wakarchuk MF, Baillie DL (1994) The Caenorhabditis elegans unc-60 gene encodes proteins homologous to a family of actin-binding proteins. Mol Gen Genet 242:346-357.
22. A receptor. Brain Res Mol Brain Res 28:175-179.
23. Mello CC, Kramer JM, Stinchcomb D, Ambros V (1991) Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J 10:3959-3970.
24. Meyer G, Kirsch J, Betz H, Langosch D (1995) Identification of a gephyrin binding motif on the glycine receptor beta subunit. Neuron 15:563-572.
25. A and glycine receptors. Nature 389:385-389.
26. Moss SJ, Smart TG (1996) Modulation of amino acid-gated ion channels by protein phosphorylation. Int Rev Neurobiol 39:1-52.
27. A receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J Neurosci 18:1693-1703.
28. Okkema PG, Fire A (1994) The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle. Development 120:2175-2186.
29. A receptors. FASEB J 4:1469-1480.
30. Rodriguez IR, Mazuruk K, Schoen TJ, Chader GJ (1994) Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters. J Biol Chem 269:31969-31977.
31. Wilson R, Ainscough R, Anderson K, Baynes C, Berks M, Bonfield J, Burton J, Connell M, Copsey T, Cooper J, Coulson A, Craxton M, Dear S, Du Z, Durbin R, Favello A, Fraser A, Fulton L, Gardner A, Green P, Hawkins T, Hillier L, Jier M, Johnston L, Jones M, Kershaw J, Kirsten J, Laisster N, Latreille P, Lightning J, Lloyd C, Mortimore B, O'Callaghan M, Parsons J, Percy C, Rifken L, Roopra A, Saunders D, Shownkeen R, Sims M, Smaldon N, Smith A, Smith M, Sonnham-mer E, Staden R, Sulston J, Thierry-Mieg J, Thomas K, Vaudin M, Vaughan K, Waterston R, Watson A, Weinstock L, Wilkinson-Sproat J, Wohldman P (1994) 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature 368:32-38.