Fluorosulfonyl- and bis-(β-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: Irreversible antagonists at the human a3 adenosine receptor and molecular modeling studies

Journal of Medicinal Chemistry

Volumn 44, Issue 17, 2001, Pages 2735-2742

  Baraldi, P G ^a   Cacciari, B ^a   Moro, S ^b   Romagnoli, R ^a   Ji, X D ^c   Jacobson, K A ^c   Gessi, S ^a   Borea, P A ^a   Spalluto, G ^d  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d UNIVERSITY OF TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5 [[(4 FLUOROSULFONYLPHENYL)AMINO]CARBONYL]AMINO 8 N PROPYL 2 (2 FURYL)PYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; BIS(BETA CHLOROETHYL)AMINOPHENYLAMINOPYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE; PYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; ENZYME INHIBITION; MOLECULAR CLONING; MOLECULAR MODEL; NONHUMAN; PROTEIN SECONDARY STRUCTURE; RAT; REACTION ANALYSIS; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

ANILINE COMPOUNDS; ANIMALS; BINDING, COMPETITIVE; CELL LINE; CRICETINAE; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MODELS, MOLECULAR; PHENYLUREA COMPOUNDS; PYRIMIDINES; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0035899176     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010818a     Document Type: Article

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