Differential A1 adenosine receptor reserve for two actions of adenosine on guinea pig atrial myocytes

Molecular Pharmacology

Volumn 52, Issue 4, 1997, Pages 683-691

  Srinivas, Miduturu ^a   Shryock, John C ^b   Dennis, Donn M ^b   Baker, Stephen P ^a   Belardinelli, Luiz ^a,b  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 6 N CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 METHYL 6 N (2 NORBORNYL)ADENINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A1 RECEPTOR ANTAGONIST; GUANOSINE TRIPHOSPHATE; ISOPRENALINE; POTASSIUM ION; SHA 040; UNCLASSIFIED DRUG; 8 CYCLOPENTYL 3 (3 ((4 (FLUOROSULFONYL)BENZOYL)OXY)PROPYL) 1 PROPYLXANTHINE; 8-CYCLOPENTYL-3-(3-((4-(FLUOROSULFONYL)BENZOYL)OXY)PROPYL)-1-PROPYLXANTHINE; ADENOSINE RECEPTOR; DRUG DERIVATIVE; POTASSIUM CHANNEL; XANTHINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION CONSTANT; GUINEA PIG; HEART ATRIUM MUSCLE; HEART MUSCLE CELL; ION CURRENT; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; ANIMAL; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; HEART ATRIUM; METABOLISM;

ADENOSINE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HEART ATRIA; POTASSIUM CHANNELS; RECEPTORS, PURINERGIC P1; XANTHINES;

EID: 0030612635     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.4.683     Document Type: Article

References (40)

1. Belardinelli, L., J. C. Shryock, Y. Song, D. Wang, and M. Srinivas. Ionic basis for the electrophysiological actions of adenosine on cardiomyocytes. FASEB J. 9:359-365 (1995).
2. Olah, M. E., and G. L. Stiles. Adenosine receptor subtypes: characterization and therapeutic regulation. Annu. Rev. Pharmacol. Toxicol. 35:581-606 (1995).
3. Martynyuk, A. E., K. A. Kane, S. M. Cobbe, and A. C. Rankin. Adenosine increases potassium conductance in isolated rabbit atrioventricular nodal myocytes. Cardiovasc. Res. 30:668-675 (1995).
4. Wang, D., J. C. Shryock, and L. Belardinelli. Cellular basis for the negative dromotropic effect of adenosine on rabbit single atrioventricular nodal cells. Circ. Res. 78:697-706 (1996).
5. Wang, D., and L. Belardinelli. Mechanism of the negative inotropic effect of adenosine in guinea pig atrial myocytes. Am. J. Physiol. 267:H2420-H2429 (1994).
6. + channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins. Pflueg. Arch. Eur. J. Physiol. 407:264-274 (1986).
7. Dobson, J. G. Reduction by adenosine of the isoproterenol induced increase in cyclic adenosine 3′,5′-monophosphate formation and glycogen phosphorylase activity in rat heart muscle. Circ. Res. 43:785-792 (1978).
8. Hazeki, O., and M. Ui. Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells. J. Biol. Chem. 256:2856-2862 (1981).
9. Isenberg, G., and L. Belardinelli. Ionic basis for the antagonism between adenosine and isoproterenol on isolated mammalian ventricular myocytes. Circ. Res. 55:309-325 (1984).
10. Cerbai, E., U. Klöckner, and G. Isenberg. Ca-antagonist effects of adenosine in guinea pig atrial cells. Am. J. Physiol. 255:H872-H878 (1988).
11. +-channel-coupled adenosine receptor in guinea pig atria. Naunyn-Schmiedeberg's Arch. Pharmacol. 340:684-688 (1989).
12. Wilken, A., H. Tawfik-Schlieper, K.-N. Klotz, and U. Schwabe. Pharmacological characterization of the adenylate cyclase-coupled adenosine receptor in isolated guinea pig atrial myocytes. Mol. Pharmacol. 37:916-920 (1990).
13. Kenakin, T. P. Stimulus-response mechanisms, in Pharmacologic Analysis of Drug-Receptor Interaction. 2nd ed. Raven Press, New York, NY (1993).
14. Ruffolo, R. R. Important concepts of receptor theory. J. Auton. Pharmacol. 2:277-295 (1982).
15. Furchgott, R. F., and P. Bursztyn. Comparison of dissociation constants and of relative efficacies of selected agonists acting on parasympathetic receptors. Ann. N. Y. Acad. Sci. 144:882-899 (1967).
16. 1-adenosine receptor. Mol. Pharmacol. 50:196-205 (1996).
17. 2-adenosine receptors. J. Med Chem. 34:1340-1344 (1991).
18. Isenberg, G., and U. Klöckner. Calcium tolerant myocytes prepared by pre-incubation in a 'KB medium.' Pflueg. Arch. Eur. J. Physiol. 395:6-18 (1982).
19. Hamill, O. P., A. Marty, E. Neher, B. Sakmann, and F. J. Sigworth. Improved patch clamp techniques for high resolution current recordings from cells and cell-free membrane patches. Pflueg. Arch. Eur. J. Physiol. 391:85-100 (1981).
20. Lohse, M. J., D. Ukena, and U. Schwabe. Demonstration of Ri-type adenosine receptors in bovine myocardium by radioligand binding. Naunyn-Schmiedeberg's Arch Pharmacol. 328:310-316 (1985).
21. 50) of an enzymatic reaction. Biochem. Pharmacol. 22:3099-3108 (1973).
22. Ringdahl, B. Selectivity of partial agonists related to oxotremorine based on differences in muscarinic receptor reserve between the guinea pig ileum and urinary bladder. Mol. Pharmacol. 31:351-356 (1987).
23. Kenakin, T. P., and D. Beek. Is prenaterol (H133/80) really a selective beta-1-adrenoceptor agonist? Tissue selectivity resulting from differences in stimulus-response relationships. J. Pharmacol. Exp. Ther. 213:406-413 (1980).
24. Meller, E., K. Bohmaker, Y. Namba, A. J. Friedhoff, and M. Goldstein. Relationship between receptor occupancy and response at striatal dopamine autoceptors. Mol. Pharmacol. 31:592-598 (1987).
25. Brown, J. H, and D. Goldstein. Differences in muscarinic receptor reserve for inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis in chick heart cells. Mol. Pharmacol. 30:466-470 (1986).
26. James, S. R, C. Vaziri, T. R. Walker, G. Milligan, and C. P. Downes. The turkey erythrocyte β-adrenergic receptor couples to both adenylate cyclase and phospholipase C via distinct G-protein α-subunits. Biochem. J. 304: 359-364 (1994).
27. Zhong, H., K. P. Minneman. Coexisting beta-1 and beta-2-adrenergic receptors with differential receptor reserves in rat C6 glioma cells. J. Pharmacol. Exp. Ther. 272:1088-1094 (1995).
28. Milligan, G. Mechanisms of multifunctional signaling by G-protein linked receptors. Trends Pharmacol. Sci. 14:239-244 (1993).
29. Wickman, K, and D. E. Clapham. Ion channel regulation by G-proteins. Physiol. Rev. 75:865-885 (1995).
30. Sunhara, R. K., C. W. Dessauer, and A. G. Gilman. Complexity and diversity of mammalian adenylyl cyclases. Annu. Rev. Pharmacol. Toxicol. 36:461-480 (1996).
31. 3H]adenosine to synaptosomal and other preparations from the mammalian brain. Biochem. J. 194:611-620 (1981).
32. Linden, J. Adenosine deaminase for removing adenosine: how much is enough? Trends Pharmacol. Sci. 10:260-262 (1989).
33. 1 adenosine receptor function in genetic obesity. FASEB J. 8:72-80 (1994).
34. Balakrishnan, V. S, G. A. Coles, and J. D. Williams. A potential role for endogenous adenosine in control of human glomerular and tubular function. Am. J. Physiol. 265:F504-F510 (1993).
35. Tietjan, C. S., C. G. Tribble, J. M. Gidday, C. L. Phillips, L. Belardinelli, R. Rubio, and R. M. Berne. Interstitial adenosine in guinea pig hearts: an index obtained by epicardial disks. Am. J. Physiol. 259:H1471-H1476 (1990).
36. Mohrman, D. E., and L. J. Heller. Transcapillary adenosine transport in isolated guinea pig and rat hearts. Am. J. Physiol. 259:H772-H783 (1990).
37. 1-adenosine receptor in the anaesthetized pig: pharmacological and therapeutic implications. Cardiovasc. Res. 28:621-628 (1994).
38. Headrick, J., and R. J. Willis. Mediation by adenosine of bradycardia in rat heart during graded global ischemia. Pflueg. Arch. Eur. J. Physiol. 412: 618-623 (1988).
39. Schrader, J. Sites of action and production of adenosine in the heart, in Purinergic Receptors (G. Burnstock, ed.). Chapman and Hall, London, 121-162 (1981).
40. Dobson, J. G., R. W. Ordway, and R. A. Fenton. Endogenous adenosine inhibits catecholamine contractile responses in the normoxic heart. Am. J. Physiol 251:H455-H462 (1986).