Nuclear import of histone H2A and H2B is mediated by a network of karyopherins

Journal of Cell Biology

Volumn 153, Issue 2, 2001, Pages 251-262

  Mosammaparast, Nima ^a   Jackson, Kelley R ^a   Guo, Yurong ^b   Brame, Cynthia J ^b   Shabanowitz, Jeffrey ^b   Hunt, Donald F ^a,b   Pemberton, Lucy F ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Histone; Karyopherin; Nuclear import; Nuclear localization signal; Yeast

Indexed keywords

CHAPERONE; GREEN FLUORESCENT PROTEIN; HISTONE H2A; HISTONE H2B; HYBRID PROTEIN; KARYOPHERIN; PROTEIN; PROTEIN KAP114P; PROTEIN KAP121P; PROTEIN KAP123P; PROTEIN KAP95; PROTEIN NAP1P; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL CYCLE; CELL NUCLEUS; CHROMATIN STRUCTURE; COMPLEX FORMATION; CYTOSOL; GENE; GENE MUTATION; KAP GENE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; TEMPERATURE SENSITIVE MUTANT;

ACTIVE TRANSPORT, CELL NUCLEUS; CELL CYCLE PROTEINS; CELL NUCLEUS; GENES, REPORTER; HISTONES; HUMANS; IMMUNOBLOTTING; MACROMOLECULAR SUBSTANCES; MICROSCOPY, FLUORESCENCE; MOLECULAR CHAPERONES; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEINS; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; YEASTS;

EID: 0035897406     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.2.251     Document Type: Article

References (54)

1. Chromatin assembly: Biochemical identities and genetic redundancy
2. Kap104p: A karyopherin involved in the nuclear transport of messenger RNA binding proteins
3. Two novel related yeast nucleoporins Nup170p and Nup157p: Complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p
4. A novel nuclear import pathway for the transcription factor TFIIS
5. Facilitated nuclear transport of histone H1 and other small nucleophilic proteins
6. Histones in transit: Cytosolic histone complexes and diacetylation of H4 during nucleosome assembly in human cells
7. The two yeast histone H2A genes encode similar protein subtypes
8. Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes
9. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
10. An improved procedure for enzymatic digestion of polyvinylidene difluoride -bound proteins for internal sequence analysis
11. Peptide-mass profiles of polyvinylidene difluoride-bound proteins by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in the presence of nonionic detergents
12. A novel class of RanGTP binding proteins
13. Transport between the cell nucleus and the cytoplasm
14. Purification and initial characterization of a protein which facilitates assembly of nucleosome-like structure from mammalian cells
15. Drosophila NAP-1 is a core histone chaperone that functions in ATP-facilitated assembly of regularly spaced nucleosomal arrays
16. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
17. The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1
18. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
19. Distinct importin recognition properties of histones and chromatin assembly factors
20. Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Psel/ Kap121
21. Members of the NAP/SET family of proteins interact specifically with B-type cyclins
22. NAP1 acts with Clb1 to perform mitotic functions and to suppress polar bud growth in budding yeast
23. Dynamic localization of the nuclear import receptor and its interactions with transport factors
24. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome
25. Nuclear transport of H1 histones meets the criteria of a nuclear localization signal-mediated process
26. Nuclear transport of histone 2b in mammalian cells is signal-and energy-dependent and different from the importin alpha/beta-mediated process
27. Kap104p-mediated nuclear import. Nuclear localization signals in mRNA-binding proteins and the role of Ran and Rna
28. The yeast nuclear import receptor is required for mitosis
29. Crystal structure of the nucleosome core particle at 2.8 A resolution
30. Import of proteins into the trypanosome nucleus and their distribution at karyokinesis
31. Specific binding of the karyopherin Kap121p to a subunit of the nuclear pore complex containing Nup53p, Nup59p, and Nup170p
32. Ran and nuclear transport
33. The importin/karyopherin Kap114 mediates the nuclear import of TATA-binding protein
34. Amino acid sequences that determine the nuclear localization of yeast histone 2B
35. Transport of proteins and RNAs in and out of the nucleus
36. Green fluorescent protein as a marker for gene expression and subcellular localization in budding yeast
37. Transport routes through the nuclear pore complex
38. A distinct and parallel pathway for the nuclear import of an mRNA-binding protein
39. Nuclear import of the TATA-binding protein: Mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting
40. Protein import into nuclei: Association and dissociation reactions involving transport substrate, transport factors, and nucleoporins
41. A nuclear import pathway for a protein involved in tRNA maturation
42. Nuclear import and the evolution of a multifunctional RNA-binding protein
43. The yeast nuclear pore complex: Composition, architecture, and transport mechanism
44. A distinct nuclear import pathway used by ribosomal proteins
45. Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus
46. Importin/karyopherin protein family members required for mRNA export from the nucleus
47. Mtr1Op functions as a nuclear import receptor for the mRNA-binding protein Npl3p
48. The language of covalent histone modifications
49. The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus
50. Histone H2B genes of yeast encode two different proteins
51. Karyopherins and kissing cousins
52. Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database
53. The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins