MTHFR thermolabile genotype frequencies and longevity in Northern Ireland

Atherosclerosis

Volumn 131, Issue 1, 1997, Pages 137-138

  Harmon, Dawn L ^a   McMaster, Dorothy ^b   Shields, Denis C ^a   Whitehead, Alexander S ^a   Rea, I Maeve ^b  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Aged; Coronary heart disease; MTFHR gene

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

CARDIOVASCULAR DISEASE; GENOTYPE; HYPERHOMOCYSTEINEMIA; LETTER; PRIORITY JOURNAL;

EID: 0030964910     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(97)06096-6     Document Type: Article

References (6)

1. Tunstall-Pedoe, Kuulasmaa K, Amouyel P, Arveiler D, Rajakangas AM, Pajek A. WHO MONICA Project. Circulation 1994;40:583-612
2. Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA 1995;274:1049-1057.
3. Harmon DL, Woodside JV, Yarnell JWG et al. The common thermolabile variant of methylenetetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia. Q J Med 1996;89:571-577.
4. Motulsky AG. Nutritional ecogenetics: homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid. Am J Hum Genet 1996;58:17-20.
5. Gallagher PM, Meleady R, Shields DC et al. Homocysteine and risk of premature coronary heart disease: evidence for a common gene mutation. Circulation 1996;94:2154-2158
6. Schachter F, Faure-Delanef L, Guenot F et al. Genetic associations with human longevity at the APOE and ACE loci. Nature Genet 1994;6:29-32.