The frequency of the methylenetetrahydrofolate reductase-gene mutation varies with age in the normal population [6]

American Journal of Human Genetics

Volumn 61, Issue 6, 1997, Pages 1459-1460

  Matsushita, S ^a   Muramatsu, T ^a   Arai, H ^a   Matsui, T ^a   Higuchi, S ^a  

^a KURIHAMA NATIONAL HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); DNA;

ADOLESCENT; ADULT; AGE; AGED; CONTROLLED STUDY; FEMALE; GENOTYPE; HUMAN; HUMAN EXPERIMENT; HYPERTENSION; JAPAN; LETTER; MALE; MUTATION RATE; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0031458361     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/301640     Document Type: Letter

References (6)

1. CJ Boushey SSA Beresford GS Omenn A Motulsky A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes JAMA 274 1995 1049 1057
2. AMT Engbersen DG Franken GHJ Boers EMB Stevens FJM Trijbels HJ Blom Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia Am J Hum Genet 56 1995 142 150
3. P Frosst HJ Blom R Milos P Goyette CA Sheppard RG Matthews GJH Boers A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Nat Genet 10 1995 111 113
4. Health and Welfare Statistics Association Trends in national health conditions, 1995 1995 Health and Welfare Statistics Association Tokyo
5. SS Kang EL Passen N Ruggie PWK Wong H Sora Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease Circulation 88 1993 1463 1469
6. LAJ Kluijtmans LPWJ van den Heuvel GHJ Boers P Frosst EMB Stevens BA van Oost M den Heijer Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease Am J Hum Genet 58 1996 35 41