The role of intracellular Na+ and mitochondria in buffering of kainate-induced intracellular free Ca2+ changes in rat forebrain neurones

Journal of Physiology

Volumn 509, Issue 1, 1998, Pages 103-116

  Hoyt, Kari R ^a   Stout, Amy K ^a   Cardman, Jamie M ^a   Reynolds, Ian J ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; CALCIUM ION; GLUTAMATE RECEPTOR; KAINIC ACID; KAINIC ACID RECEPTOR; SODIUM ION; UNCLASSIFIED DRUG; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL CELL; ARTICLE; BRAIN MITOCHONDRION; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL STIMULATION; CONTROLLED STUDY; EMBRYO; FOREBRAIN; MITOCHONDRIAL MEMBRANE; NERVE CELL; NERVE CELL CULTURE; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM CALCIUM EXCHANGE; SODIUM CELL LEVEL; TIME; BRAIN NERVE CELL; CALCIUM HOMEOSTASIS; CONCENTRATION RESPONSE; FEMALE; FLUORESCENCE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION;

ANIMALS; CALCIUM; CELLS, CULTURED; CLONAZEPAM; EXCITATORY AMINO ACID AGONISTS; FLUORESCENT DYES; KAINIC ACID; MEMBRANE POTENTIALS; MITOCHONDRIA; NEURONS; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SODIUM; SODIUM-CALCIUM EXCHANGER; STIMULATION, CHEMICAL; THIAZEPINES;

EID: 0032523737     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.103bo.x     Document Type: Article

References (42)

1. 2+ exchange enhances delayed neuronal death elicited by glutamate in cerebellar granule cell cultures. Brain Research 548, 322-325.
2. ANKARCRONA, M., DYPBUKT, J. M., BONFOCO, E., ZHIVOTOVSKY, B., ORRENIUS, S., LIPTON, S. A. & NICOTERA, P. (1995). Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15, 961-973.
3. BUDD, S. L. & NICHOLLS, D. G. (1996). Mitochondria, calcium regulation and acute glutamate excitotoxicity in cultured cerebellar granule cells. Journal of Neurochemistry 67, 2282-2291.
4. COLWELL, C. S. & LEVINE, M. S. (1996). Glutamate receptor-induced toxicity in neostriatal cells. Brain Research 724, 205-212.
5. COURTNEY, M. J., ENKVIST, M. O. K. & AKERMAN, K. E. O. (1995). The calcium response to the excitotoxin kainate is amplified by subsequent reduction of extracellular sodium. Neuroscience 68, 1051-1057.
6. DUBINSKY, J. M. & ROTHMAN, S. M. (1991). Intracellular calcium concentrations during 'chemical hypoxia' and excitotoxic neuronal injury. Journal of Neuroscience 11, 2545-2551.
7. EIMERL, S. & SCHRAMM, M. (1994). The quantity of calcium that appears to induce neuronal death. Journal of Neurochemistry 62, 1223-1226.
8. EISNER, D. A. & LEDERER, W. J. (1985). Na-Ca exchange: stoichiometry and electrogenicity. American Journal of Physiology 248, C189-202.
9. HARTLEY, D. M. & CHOI, D. W. (1989). Delayed rescue of N-methyl-D-aspartate receptor mediated neuronal injury in cortical culture. Journal of Pharmacology and Experimental Therapeutics 250, 752-758.
10. 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. Journal of Neuroscience 13, 1993-2000.
11. i increases in cultured rat forebrain neurons. Molecular Pharmacology (in the Press).
12. 2+ in cultured neurons from rat brain. Journal of Neurochemistry 64, 2049-2056.
13. HYRC, K., HANDRAN, S. D., ROTHMAN, S. M. & GOLDBERG, M. P. (1997). Ionized intracellular calcium concentration predicts excitotoxic neuronal death: observations with low affinity fluorescent calcium indicators. Journal of Neuroscience 17, 6669-6677.
14. 2+-dependent collapse of mitochondrial membrane potential and ultrastructural alterations of mitochondria. FEBS Letters 392, 143-147.
15. 2+ overload induced by endogenous excitatory amino acids following a glutamate pulse. FEBS Letters 393, 135-138.
16. KIEDROWSKI, L., BROOKER, G., COSTA, E. & WROBLEWSKI, J. T. (1994a). Glutamate impairs neuronal calcium extrusion while reducing sodium gradient. Neuron 12, 295-300.
17. KIEDROWSKI, L. & COSTA, E. (1995). Glutamate-induced destabilization of intracellular calcium concentration homeostasis in cultured cerebellar granule cells: role of mitochondria in calcium buffering. Molecular Pharmacology 47, 140-147.
18. KIEDROWSKI, L., WROBLEWSKI, J. T. & COSTA, E. (1994b). Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate. Molecular Pharmacology 45, 1050-1054.
19. KOH, J. Y., GOLDBEBO, M. P., HARTLEY, D. M. & CHOI, D. W. (1990). Non-NMDA receptor mediated neurotoxicity in cortical culture. Journal of Neuroscience 10, 693-705.
20. 2+ influx underlies potent induction of injury. Journal of Neuroscience 16, 5457-5465.
21. 2+ in mammalian neurons. Trends in Pharmacological Sciences 11, 254-260.
22. MICHAELS, R. L. & ROTHMAN, S. M. (1990). Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations. Journal of Neuroscience 10, 283-292.
23. 2+ homeostasis. Progress in Neurobiology 37, 255-285.
24. MURPHY, S. N., THAYER, S. A. & MILLER, R. J. (1987). The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro. Journal of Neuroscience 7, 4145-4158.
25. NEHER, E. (1995). The use of fura-2 for estimating Ca buffers and Ca fluxes. Neuropharmacology 34, 1423-1442.
26. NICHOLLS, D. G. & AKERMAN, K. E. O. (1982). Mitochondrial calcium transport. Biochimica et Biophysica Acta 683, 57-88.
27. NIEMINEN, A.-L., PETRIE, T. G., LEMASTERS, J. J. & SELMAN, W. R. (1996). Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: evidence of the mitochodrial permeability transition. Neuroscience 75, 993-997.
28. PETRONILLI, V., NICOLLI, A., CONSTANTI, P., COLONNA, R. & BERNARDI, P. (1994). Regulation of the permeability transition pore, a voltage dependent mitochondrial channel inhibited by cyclosporin A. Biochimica et Biophysica Acta 1187, 255-259.
29. PINELIS, V. G., SEGAL, M., GREENBERGER, V. & KHODOROV, B. I. (1994). Changes in cytosolic sodium caused by a toxic glutamate treatment of cultured hippocampal neurons. Biochemistry and Molecular Biology International 32, 475-482.
30. POZZAN, T., RIZZUTO, R., VOLPE, P. & MELDOLESI, J. (1994). Molecular and cellular physiology of intracellular calcium stores. Physiological Reviews 74, 595-636.
31. REYNOLDS, I. J. & HASTINGS, T. G. (1995). Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. Journal of Neuroscience 15, 3318-3327.
32. SCHINDER, A. F., OLSON, E. C., SPITZER, N. C. & MONTAL, M. (1996). Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. Journal of Neuroscience 16, 6125-6133.
33. 2+ efflux in rat forebrain neurones in culture. Journal of Physiology 492, 641-657.
34. STOUT, A. K. & REYNOLDS, I. J. (1998). High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations. Neuroscience (in the Press).
35. THAYER, S. A. & MILLER, R. J. (1990). Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro. Journal of Physiology 425, 85-115.
36. TYMIANSKI, M., CHARLTON, M. P., CARLEN, P. L. & TATOR, C. H. (1993). Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. Journal of Neuroscience 13, 2085-2104.
37. 2+ loads by mitochondria in cultured rat hippocampal neurons. Journal of Neurophysiology 76, 1611-1621.
38. WERTH, J. L. & THAYER, S. A. (1994). Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons. Journal of Neuroscience 14, 348-356.
39. 2+ exchange buffer glutamate-induced calcium loads in cultured cortical neurons. Journal of Neuroscience 15, 1318-1328.
40. WHITE, R. J. & REYNOLDS, I. J. (1996). Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure. Journal of Neuroscience 16, 5688-5697.
41. 2+ following intense glutamate stimulation of cultured rat forebrain neurones. Journal of Physiology 498, 31-47.
42. ZORATTI, M. & SZABO, I. (1995). The mitochondrial permeability transition. Biochimica et Biophysica Acta 1241, 139-176.