Ca2+ permeability and Joro spider toxin sensitivity of AMPA and kainate receptors on cerebellar granule cells

European Journal of Pharmacology

Volumn 351, Issue 1, 1998, Pages 131-138

  Savidge, Jonathan R ^a   Bristow, David R ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Ca2+ channel, voltage gated; Ca2+, intracellular; GluR2 subunit; GluR5 subunit; GluR6 subunit; GYKI 53655

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; AMPA RECEPTOR; CALCIUM ION; CYCLOTHIAZIDE; KAINIC ACID RECEPTOR; NIFEDIPINE; SPIDER VENOM; UNCLASSIFIED DRUG; AMINO ACID RECEPTOR BLOCKING AGENT; BENZODIAZEPINE DERIVATIVE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; FURA 2; JSTX SPIDER TOXIN; MANGANESE; SODIUM;

ANIMAL CELL; ARTICLE; CALCIUM BINDING; CALCIUM CELL LEVEL; CONTROLLED STUDY; GRANULE CELL; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; TOXIN ANALYSIS; VOLTAGE CLAMP; ANIMAL; CELL CULTURE; CEREBELLUM; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM;

ANIMALS; BENZODIAZEPINES; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELLS, CULTURED; CEREBELLUM; EXCITATORY AMINO ACID ANTAGONISTS; FURA-2; MANGANESE; NIFEDIPINE; RATS; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; SODIUM; SPIDER VENOMS;

EID: 0032510841     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00280-5     Document Type: Article

References (28)

1. Blaschke, M., Keller, B.U., Rivosecchi, R., Hollmann, M., Heinemann, S., Konnerth, A., 1993. A single amino acid determines the subunit-specific spider toxin block of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor channels. Proc. Natl. Acad. Sci. USA 90, 6528-6532.
2. Bochet, P., Audinat, E., Lambolez, B., Crepel, F., Rossier, J., Iino, M., Tsuzuki, K., Ozawa, S., 1994. Subunit composition at the single-cell level explains functional properties of a glutamate-gated channel. Neuron 12, 383-388.
3. Brorson, J.R., Bleakman, D., Chard, P.S., Miller, R.J., 1992. Calcium directly permeates kainate/α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in cultured cerebellar purkinje neurons. Mol. Pharmacol. 41, 603-608.
4. 1 subunit protein in rat cerebellar granule cells. Br. J. Pharmacol. 118, 1103-1110.
5. Burnashev, N., Monyer, H., Seeburg, P.M., Sakmann, B., 1992. Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit. Neuron 8, 189-198.
6. Burnashev, N., Zhou, Z., Neher, E., Sakmann, B., 1995. Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. J. Physiol. 485, 403-418.
7. Burnashev, N., Villarroel, A., Sakmann, B., 1996. Dimensions and ion selectivity of recombinant AMPA and kainate receptor channels and their dependence on Q/R site residues. J. Physiol. 496, 165-173.
8. Castillo, P.E., Malenka, R.C., Nicoll, R.A., 1997. Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons. Nature 388, 182-186.
9. Clarke, V.R.J., Ballyk, B.A., Hoo, K.H., Mandelzys, A., Pellizzai, A., Bath, C.P., Thomas, J., Sharpe, E.F., Davies, C.H., Ornstein, P.L., Shoepp, D.D., Kamboj, R.K., Collingridge, G.L., Lodge, D., Bleakman, D., 1997. A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 389, 599-603.
10. Collingridge, G.L., Lester, R.A.S., 1989. Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol. Rev. 40, 143-210.
11. 2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6. Proc. Natl. Acad. Sci. USA 90, 755-759.
12. Fletcher, E.J., Lodge, D., 1996. New developments in the molecular pharmacology of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate and kainate receptors. Pharmacol. Ther. 70, 65-89.
13. 2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron 15, 193-204.
14. Herb, A., Burnashev, N., Werner, P., Sakmann, B., Wisden, W., Seeburg, P.H., 1992. The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits. Neuron 8, 775-785.
15. 2+-permeable AMPA receptors by joro spider toxin in cultured rat hippocampal neurones. J. Physiol. 496, 431-437.
16. 2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing. Neuron 10, 491-500.
17. Lerma, J., 1997. Kainate reveals its targets. Neuron 19, 1155-1158.
18. 2+ in mammalian neurons. Trends Pharmacol. Sci. 11, 254-260.
19. 2+-permeable AMPA receptors in cortical glia. J. Neurosci. 16, 519-530.
20. 2+ channel currents in rat cerebellar granule neurons. J. Neurosci. 15, 2995-3012.
21. Ruano, D., Lambolez, B., Rossier, J., Paternain, A.V., Lerma, J., 1995. Kainate receptor subunits expressed in single cultured hippocampal neurons: molecular and functional variants by RNA editing. Neuron 14, 1009-1017.
22. 2+-permeable AMPA receptors among cultured rat cerebellar granule cells. NeuroReport 8, 1877-1882.
23. +-stimulated calcium entry in rat cerebellar granule cells. Neurosci. Lett. 229, 109-112.
24. Savidge, J.R., Bleakman, D., Bristow, D.R., 1997. Identification of kainate receptor-mediated intracellular calcium increases in cultured rat cerebellar granule cells. J. Neurochem. 69, 1763-1766.
25. 2+ quench of fura-2 fluorescence. Eur. J. Neurosci. 7, 831-840.
26. Sommer, B., Kohler, M., Sprengel, R., Seeburg, P.H., 1991. RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell 67, 11-19.
27. Vignes, M., Collingridge, G.L., 1997. The synaptic activation of kainate receptors. Nature 388, 179-182.
28. 1 receptor in GT1-7 neuronal cells is regulated by calcium influx and KN-62, a putative inhibitor of calcium/calmodulin protein kinase II. Br. J. Pharmacol. 118, 1119-1126.