Site-specific thrombin receptor antibodies inhibit Ca2+ signaling and increased endothelial permeability

American Journal of Physiology - Cell Physiology

Volumn 273, Issue 5 42-5, 1997, Pages

  Nguyen, Lan T ^b   Lum, Hazel ^a   Tiruppathì, Chinnaswamy ^a   Malik, Asrae B ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Intracellular calcium concentration; Tethered ligand

Indexed keywords

ALBUMIN; CALCIUM ION; IODINE 125; THROMBIN RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CATTLE; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANIMALIA; BOS TAURUS;

EID: 0030686584     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1997.273.5.c1756     Document Type: Article

References (26)

1. Ades, E. W., F. J. Candal, R. A. Swerlick, V. G. George, S. Summers, D. C. Bosse, and T. J. Lawley. HMEC-1-establishment of an immortalized human microvascular endothelial cell line. J. Invest. Dermatol. 99: 683-690, 1992.
2. Bahou, W. F., B. S. Coller, C. L. Potter, K. J. Norton, J. L. Kutok, and M. S. Goligorsky. The thrombin receptor extracellular domain contains sites crucial for peptide ligand-induced activation. J. Clin. Invest. 91: 1405-1413, 1993.
3. Bussolino, F., F. Silvagno, G. Garbarino, C. Costamagna, F. Sanavio, M. Arese, R. Soldi, M. Aglietta, G. Pescarmona, G. Camussi, and A. Bosia. Human endothelial cells are targets for platelet-activating factor (PAF). Activation of a and β protein kinase C isozymes in endothelial cells stimulated by PAF. J. Biol. Chem. 269: 2877-2886, 1994.
4. Connolly, A. J., H. Ishihara, M. L. Kahn, R. V. Farese, and S. R. Coughlin. Role of the thrombin receptor in development and evidence for a second receptor. Nature 381: 516-519, 1996.
5. Cooper, J. A., P. J. Delvecchio, F. L. Minnear, K. E. Burhop, W. M. Selig, J. G. N. Garcia, and A. B. Malik. Measurement of albumin permeability across endothelial monolayers in vitro. J. Appl. Physiol. 62: 1076-1083, 1987.
6. Fenton, J. W., II. Thrombin bioregulatory functions. Adv. Clin. Enzymol. 6: 186-193, 1988.
7. 2+ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet-derived growth factor mRNA expression in cultured endothelium. J. Cell. Physiol. 156: 541-549, 1993.
8. Garcia, J. G. N., A. Siflinger-Birnboim, R. Bizios, P. J. Delvecchio, J. W. Fenton II, and A. B. Malik. Thrombin-induced increase in albumin permeability across the endothelium. J. Cell. Physiol. 128: 96-104, 1986.
9. Gerszten, R. E., J. Chen, M. Ishii, K. Ishii, L. Wang, T. Nanevicz, C. W. Turck, T.-K. H. Vu, and S. R. Coughlin. Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface. Nature 368: 648-651, 1994.
10. Goeckeler, Z. M., and R. B. Wysolmerski. Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation. J. Cell Biol. 130: 613-627, 1995.
11. Goligorsky, M. S., D. N. Menton, A. Laszlo, and H. Lum. Nature of thrombin-induced sustained increase in cytosolic calcium concentration in cultured endothelial cells. J. Biol. Chem. 264: 16771-16775, 1989.
12. Ishihara, H., A. J. Connolly, D. W. Zeng, M. L. Kahn, Y. W. Zheng, C. Timmons, T. Tram, and S. R. Coughlin. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 386: 502-506, 1997.
13. Lum, H., T. T. Andersen, A. Siflinger-Birnboim, C. Tiruppathi, M. S. Goligorsky, J. W. Fenton II, and A. B. Malik. Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization. J. Cell Biol. 120: 1491-1499, 1993.
14. 2+ and inositpl polyphosphates. Am. J. Physiol. 263 (Lung Cell. Mol. Physiol. 7): L219-L225, 1992.
15. Lum, H., P. J. Delvecchio, A. S. Schneider, M. S. Goligorsky, and A. B. Malik. Calcium dependence of the thrombin-induced increases in endothelial albumin permeability. J. Appl. Physiol. 66: 1471-1476, 1989.
16. Lynch, J. J., T. J. Ferro, F. A. Blumenstock, A. M. Brockenauer, and A. B. Malik. Increased endothelial albumin permeability mediated by protein kinase C activation. J. Clin. Invest. 85: 1991-1998, 1990.
17. Nagpala, P. G., A. B. Malik, P. T. Vuong, and H. Lum. Protein kinase C beta(1) overexpression augments phorbol ester-induced increase in endothelial permeability. J. Cell. Physiol. 166: 249-255, 1996.
18. Ngaiza, J. R., and E. A. Jaffe. A14 amino acid peptide derived from the amino terminus of the cleaved thrombin receptor elevates intracellular calcium and stimulates prostacyclin production in human endothelial cells. Biochem. Biophys. Res. Commun. 179: 1656-1661, 1991.
19. Nystedt, S., V. Ramakrishnan, and J. Sundelin. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells - comparison with the thrombin receptor. J. Biol. Chem. 271: 14910-14915, 1996.
20. Sheldon, R., A. Moy, K. Lindsley, S. Shasby, and D. M. Shasby. Role of myosin light-chain phosphorylation in endothelial cell retraction. Am. J. Physiol. 265 (Lung Cell. Mol. Physiol. 9): L606-L612, 1993.
21. 2+]i and their determination using fluorescent probes. J. Biol. Chem. 266: 1410-1414, 1991.
22. Siflinger-Birnboim, A., M. S. Goligorsky, P. J. Delvecchio, and A. B. Malik. Activation of protein kinase C pathway contributes to hydrogen peroxide-induced increase in endothelial permeability. Lab. Invest. 67: 24-30, 1992.
23. Vouret-Craviari, V., E. Van Obberghen-Schilling, U. B. Rasmussen, A. Pavirani, J. P. Lecocq, and J. Pouyssegur. Synthetic α-thrombin receptor peptides activate G proteincoupled signaling pathways but are unable to induce mitogenesis. Mol. Biol. Cell 3: 95-102, 1992.
24. Vouret-Craviari, V., E. Van Obberghen-Schilling, J. C. Scimeca, E. Vanobberghen, and J. Pouyssegur. Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist. Biochem. J. 289: 209-214, 1993.
25. Vu, T.-K. H., D. T. Hung, V. I. Wheaton, and S. R. Coughlin. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64: 1-20, 1991.
26. Yan, W., C. Tiruppathi, R. Qiao, H. Lum, and A. B. Malik. Tumor necrosis factor decreases thrombin receptor expression in endothelial cells. J. Cell. Physiol. 166: 561-567, 1996.