Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 8, 1998, Pages 913-918

  Eda, Masahiro ^a   Ashimori, Atsuyuki ^a   Akahoshi, Fumihiko ^a   Yoshimura, Takuya ^a   Inoue, Yoshihisa ^a   Fukaya, Chikara ^a   Nakajima, Masahide ^a   Fukuyama, Hajime ^a   Imada, Teruaki ^a   Nakamura, Norifumi ^a  

^a Green Cross Company   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMASE; CHYMOTRYPSIN; ENZYME INHIBITOR; PEPTIDYL DIFLUOROMETHYLENE KETONE DERIVATIVE; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SPECIFICITY; HEART; STEREOCHEMISTRY;

ANIMALS; CATTLE; CHYMASES; CHYMOTRYPSIN; DIPEPTIDES; HUMANS; INDICATORS AND REAGENTS; KETONES; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYOCARDIUM; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17144468241     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00131-0     Document Type: Article

References (14)

1. 1. Urata, H.; Kinoshita, A.; Perez, D. M.; Misono, K. S.; Bumpus, F. M.; Graham, R. M.; Husain, A. J. Biol. Chem. 1991, 266, 17173.
2. 2. Urata, H.; Kinoshita, A.; Misono, K. S.; Bumpus, F. M.; Husain, A. J. Biol. Chem. 1990, 265, 22348.
3. 3. Peach, M. J. Phisiol. Rev. 1997, 57, 313.
4. 4. Lindpainter, K.; Ganten, D. Circ. Res. 1991, 68, 905.
5. 5. The SOLVD investigators, N. Engl. J. Med, 1991, 325, 293.
6. 6. Okunishi, H.; Miyazaki, M.; Okamura, T.; Toda, N. Biochem. Biophys. Res. Commun. 1987, 149, 1186.
7. 7. Edwards, P. D.; Bernstein, P. R. Med. Res. Rev. 1994, 14, 127.
8. 8. Powers, J. C.; Tanaka, T.; Harper, J. W.; Minematsu, Y.; Barker, L.; Lincoln, D.; Crumley, K. V.; Fraki, J. E.; Schechter, N. M.; Lazarus, G. G.; Nakajima, K.; Nakashino, K.; Neurath, H.; Woodbury, R. G. Biochemistry 1985, 24, 2048.
9. 9. Kinoshita, A.; Urata, H.; Bumpus, F. M.; Husain, A. J. Biol. Chem. 1991, 266, 19192.
10. +).
11. 11. Kolb, M.; Neises, B.; Gerhart, F. Liebigs Ann. Chem. 1990, 1.
12. 12. Easson, L. H.; Stedman, E. Proc. Roy. Soc. 1936, B121, 142.
13. 13. Thaisrivongs, S.; Pals, D.T.; Kati, W. M.; Turner, S. R.; Thomasco, L. M.; Watt, W. J. Med. Chem. 1986, 29, 2080.
14. 14. Angelastro, M. R.; Baugh, L. E.; Bey, P.; Burkhart, J. P.; Chen, T-M., Durham, S. L.; Hare, C. M.; Huber, E. W.; Janusz, M. J.; Koehl, J. R.; Marquait, A. L.; Mehdi, S.; Peet, N. P. J. Med. Chem. 1994, 37, 4538.