Potent thrombin inhibitors that probe the S1' subsite: Tripeptide transition state analogues based on a heterocycle-activated carbonyl group

Journal of Medicinal Chemistry

Volumn 39, Issue 16, 1996, Pages 3039-3043

  Costanzo, M J ^a   Maryanoff, B E ^a   Hecker, L R ^a   Schott, M R ^a   Yabut, S C ^a   Zhang, H C ^a   Andrade Gordon, P ^a   Kauffman, J A ^a   Lewis, J M ^a   Krishnan, R ^a   Tulinsky, A ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOTHIAZOLE DERIVATIVE; CARBONYL DERIVATIVE; PEPTIDE DERIVATIVE; THROMBIN INHIBITOR;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; NONHUMAN; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATTLE; CRYSTALLOGRAPHY, X-RAY; GUANIDINES; HUMANS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PEPTIDES; PIPECOLIC ACIDS; PROTEIN BINDING; SERINE PROTEINASE INHIBITORS; THIAZOLES; THROMBIN; TRYPSIN INHIBITORS;

EID: 0029742578     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9603274     Document Type: Article

References (0)