Limited immune reconstitution at intermediate stages of HIV-1 infection during one year of highly active antiretroviral therapy in antiretroviral-naive versus non-naive adults

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 20, Issue 12, 2001, Pages 871-879

  Martin M ^a   Echevarria S ^a   Leyva Cobian F ^a   Pereda, I ^a   Lopez Hoyos M ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; GAMMA INTERFERON; INDINAVIR; INTERLEUKIN 2; NELFINAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOLOGICAL MONITORING; MALE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TREATMENT OUTCOME; VIRUS INHIBITION; VIRUS LOAD;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADP-RIBOSYL CYCLASE; ADULT; ANTIGENS, CD; ANTIGENS, CD38; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; FEMALE; HIV-1; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; MALE; MEMBRANE GLYCOPROTEINS; NAD+ NUCLEOSIDASE; TIME FACTORS;

EID: 0035712315     PISSN: 09349723     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100960100631     Document Type: Article

References (31)

1. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less
2. Immune reconstitution in HIV infection
3. Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease
4. Restoration of normal interleukin-2 production by CD4+ T cells of human immunodeficiency virus-infected patients after 9 months of highly active antiretroviral therapy
5. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes
6. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
7. Impact on the immune system of undetectable plasma HIV-1 RNA for more than 2 years
8. Immune restoration does not invariably occur following long-term HIV-1 suppression during antiretroviral therapy
9. HIV protease inhibitors restore impaired T-cell proliferative response in vivo and in vitro: A viral-suppression-independent mechanism
10. CD8, CD38+ and CD8 DR+ peripheral blood lymphoid subsets of HIV-infected intravenous drug abusers correlate with CD4 cell counts and proliferation to mitogens
11. Immunological and virological responses in HIV-1-infected adults at early stage of established infection treated with highly active antiretroviral therapy
12. Clinical and immunological response without decrease in viral load in patients with AIDS after 24 months of highly active antiretroviral therapy
13. Immunological benefits of antiretroviral therapy in very early stages of asymptomatic chronic HIV-1 infection
14. A randomized study comparing triple versus double antiretroviral therapy or no treatment in HIV-1-infected patients in very early stage disease: The Spanish Earth-1 study
15. Memory B and T cells
16. Lymphocyte subsets as surrogate markers in antiretroviral therapy
17. Costimulatory regulation of T cell function
18. Editorial response: Discordance between virological, immunologic, and clinical outcomes of therapy with protease inhibitors among human immunodeficiency virus-infected patients
19. Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir
20. Expansion of CD57 and CD62L-CD45RA+ CD8 T lymphocytes correlates with reduced viral plasma RNA after primary HIV infection
21. Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements
22. The prognostic significance in HIV infection of immune activation represented by cell surface antigen and plasma activation marker changes
23. Analysis of apoptosis and a Th1/Th2 phenotype in HIV-infected patients
24. Cytokine patterns in adults with AIDS
25. T(H)1 to T(H)2 shift of cytokines in peripheral blood of HIV-infected patients is detectable by reverse transcriptase polymerase chain reaction but not by enzyme-linked immunosorbent assay under nonstimulated conditions
26. Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry
27. Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals: Decreased IFN-gamma in the presence of preserved IL-4 production
28. Abnormal intracellular IL-2 and interferon-gamma (IFN-gamma) production as HIV-1-associated markers of immune dysfunction
29. Functional characterization and modulation of cytokine production by CD8+ T cells from human immunodeficiency virus-infected individuals
30. A TH1-TH2 switch is a critical step in the etiology of HIV infection
31. Kinetics of the changes of lymphocyte subsets defined by cytokine production at single cell level during highly active antiretroviral therapy for HIV infection