Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry

AIDS

Volumn 11, Issue 9, 1997, Pages 1111-1118

  Klein, Stefan A ^a,b   Dobmeyer, Jürgen M ^a   Dobmeyer, Thomas S ^a   Pape, Martine ^a   Ottmann, Oliver G ^a   Helm, Eilke B ^a   Hoelzer, Dieter ^a   Rossol, Rita ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

AIDS; Cytokines; Cytoplasmic cytokine detection; FACS; HIV; Th1 cytokines; Th2 cytokines

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONONUCLEAR CELL; NATURAL KILLER CELL; PRIORITY JOURNAL;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADULT; B-LYMPHOCYTES; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CYTOKINES; FLOW CYTOMETRY; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, CELLULAR; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-4; KILLER CELLS, NATURAL; MONOCYTES; STAINING AND LABELING; TH1 CELLS; TH2 CELLS;

EID: 0030971242     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199709000-00005     Document Type: Article

References (34)

1. Shearer GM, Clerici M: Early T-helper cell defects in HIV infection. AIDS 1991, 5:245-253.
2. Clerici M: Cell-mediated immunity in HIV infection. AIDS 1993, 7:135-40.
3. Meyaard L, Schuitemaker H, Miedema F: T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function? Immunul Today 1993, 14:161-164.
4. Klein SA, Dobmeyer JM, Dobmeyer TS, et al.: TNF-α mediated apoptosis of CD4 positive T-lymphocytes; a model of T-cell depletion in HIV infected individuals. Eur J Med Res 1996, 1:249-258.
5. Klein SA, Dobmeyer TS, Helm EB, Hoelzer D, Rossol R: Production of Th1 cytokines in lymphocytes of HIV infected individuals; detection of cytokines on single cell level by flow cytometry. Blood 1994, 84 (suppl 1):247a.
6. Clerici M, Shearer GM: A Th1→Th2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993, 14:107-111.
7. Clerici M, Shearer GM: The Th1→Th2 hypothesis of HIV infection: new insights. Immunol Today 1994, 15:575-581.
8. Meroni L, Trabattoni D, Balotta C, et al.: Evidence for type 2 cytokine production and lymphocyte activation in the early phases of HIV-1 infection. AIDS 1996, 10:23-30.
9. Barcellini W, Rizzardi GP, Orietta Borghi M, Fain C, Lazzarin A, Meroni PL: TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients. AIDS 1994, 8:757-762.
10. Clerici M, Wynn TA, Berzofsky JA, et al.: Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J Clin Invent 1994, 93:768-775.
11. Meyaard L, Otto SA, Keet IP, van Lier KA, Miedema F: Changes in cytokine secretion patterns of CD4+ T-cell clones in human immunodeficiency virus infection. Blood 1994, 84:4262-4268.
12. Meyaard L, Miedema F: Changes in cytokine release by CD4+ T cells in HIV-1 infection. Res Immunol 1994, 145:607-610.
13. Romagnani S, Del-Prete G, Manetti R, et al.: Role of TH1/TH2 cytokines in HIV infection. Immunol Rev 1994, 140:73-92.
14. Maggi E, Mazelli M, Ravina A, et al.: Ability of HIV to promote a Th1 to Th0 shift and to replicate preferentially in Th2 and Th0 cells. Science 1994, 265:244-248.
15. Romagnani S, Maggi E, Del-Prete G: HIV can induce a TH1 to TH0 shift, and preferentially replicates in CD4+ T-cell clones producing TH2-type cytokines. Res Immunol 1994, 145:611-617.
16. Romagnani S, Maggi E, Del Prete G: An alternative view of the Th1/Th2 switch hypothesis in HIV infection. AIDS Res Hum Retroviruses 1994, 10:3-9.
17. Romagnani S, Maggi E: Th1 versus Th2 responses in AIDS. Curr Opin Immunol 1994, 6:616-622.
18. Graziosi C, Pantaleo G, Gantt KR, et al.: Lack of evidence for the dicotomy of Th1 and Th2 predominance in HIV infected individuals. Science 1994, 265:248-252.
19. Mosman TR, Cherwinski H, Bond MW, Gledin MA, Coffman RC: Two types of murine helper T-cell clone. Definition according two profiles of lymphokine activities and secreted proteins. J Immunol 1986, 136:2348-2354.
20. Romagnani S: Biology of human TH1 and TH2 cells. J Clin Immunol 1995, 15:121-129.
21. Del Prete GF, De Carli M, Mastromauro C, et al.: Purified protein derivative of Mycobacterium tuberculosis and excretory/secretory antigens of Toxocara canis expand in vitro T-cells with stable and opposite (type 1 T helper and type 3 T helper) profile of cytokine production. J Clin Invest 1991, 88:346-350.
22. Wierenga EA, Snoek M, Jansen HM, Bos JD, van Lier RAW, Kapsenberg ML: Human atopen-specific types 1 and 2 T helper cell clones. J Immunol 1991, 147:2942-2949.
23. + lymphocyte subpopulation. J Immunol 1995, 155:4294-4301.
24. Jung T, Schauer U, Heusser C, Neumann C, Rieger C: Detection of intracellular cytokines by flow cytomery. J Immunol Methods 1993, 159:197-207.
25. Jung T, Schauer U, Rieger C, et al.: Interleukin 4 and interleukin 5 are rarely coexpressed by human T-cells. Eur J Immunol 1995, 25:2413-2416.
26. Picker LJ, Singh MK, Zdraveski Z, et al.: Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood 1995, 86:1408-1419.
27. Clerici M, Sarin A, Coffman RL, et al.: Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis. Proc Natl Acad Sci USA 1994, 91:11811-11815.
28. Clerici M, Hakim FT, Venzon DJ, et al.: Changes in interleukin-2 and interleukin-4 production in asymptomatic human immunodeficiency virus-seropositive individuals. J Clin Invest 1993, 91:759-765.
29. Caruso A, Canaris AD, Licenziati S, et al.: CD4+ and CD8+ lymphocytes of patients with AIDS synthesize increased amounts of interferon-gamma. J Acquir Immune Defic Syndr Hum Retrovirol 1995, 10:462-470.
30. Zinkernagel RM, Hengartner H: T-cell mediated immunopathology versus direct cytolysis by virus. Immunol Today 1994, 15:262-268.
31. Poli G, Biswas P, Fauci AS: Interferons in the pathogenesis and treatment of human immunodeficiency virus infection. Antiviral Res 1994, 24:221-233.
32. Rossol S, Rossol-Voth R, Laubenstein HP, et al.: Interferon production in patients with HIV-1. J Infect Dis 1989, 159:815-821.
33. Rossol-Voth R, Rossol S, Klein K, et al.: Differential gene expression of IFN and TNF-α in peripheral blood mononuclear cells from patients with AIDS related complex and AIDS. J Immunol 1990, 144:970-978.
34. Vikingsson A, Pederson K, Muller D: Enumeration of IFN-γ producing lymphocytes by flow cytometry and correlation with quantitative measurement of IFN-γ. J Immunol Methods 1994, 173:219-228.