Abnormal intracellular IL-2 and interferon-gamma (IFN-γ) production as HIV-1-associated markers of immune dysfunction

Clinical and Experimental Immunology

Volumn 111, Issue 2, 1998, Pages 257-263

  Westby, M ^b,c   Marriott, J B ^b   Guckian, M ^b   Cookson, S ^b   Hay, P ^a   Dalgleish, A G ^b  

^a ST GEORGE S HOSPITAL   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^c ROCHE PRODUCTS LTD   (United Kingdom)

Author keywords

Cell mediated immunity; Cytokines; Flow cytometry; HIV; Whole blood cultures

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; MITOGENIC AGENT;

ADULT; AGED; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; INTERFERON PRODUCTION; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0031936570     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00505.x     Document Type: Article

References (31)

1. + cell numbers and clinical staging. J Clin Invest 1989; 84:1892-9.
2. Haynes BF, Pantaleo G, Fauci AS. Toward an understanding of the correlates of protective immunity to HIV infection. Sci 1996; 271:324-8.
3. Gougeon ML, Lecoeur H, Dulioust A et al. Programmed cell death in peripheral lymphocytes from HIV-infected persons. J Immunol 1996; 156:3509-20.
4. Clerici M, Hakim FT, Venzon DJ et al. Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. J Clin Invest 1993; 91:759-65.
5. Barcellini W, Rizzardi GP, Borghi MO, Fain C, Lazzarin A, Meroni PL. Th1 and Th2 cytokine production by peripheral-bood mononuclear-cells from HIV-infected patients. AIDS 1994; 8:757-62.
6. Fan J, Bass HZ, Fahey JL. Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection. J Immunol 1993; 151:5031-40.
7. Hagiwara E, Sacks T, Leitman-Klinman SF, Klinman DM. Effect of HIV infection on the frequency of cytokine-secreting cells in human peripheral blood. AIDS Res Hum Retroviruses 1996; 12:127-33.
8. Caruso A, Canaris AD, Licenziati S et al. CD4(+) and CD8(+) lymphocytes of patients with AIDS synthesize increased amounts of interferon-gamma. J Acquir Immune Def Syndr Hum Retrovirol 1995; 10:462-70.
9. Graziosi C, Gantt KR, Vaccarezza M et al. Kinetics of cytokine expression during primary human immunodeficiency virus type I infection. Proc Natl Acad Sci USA 1996; 93:4386-91.
10. + T cells with a predominant V beta usage during the primary immune response to HIV. Nature 1994; 370:463-7.
11. Meyaard L, Hovenkamp E, Keet IP et al. Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals: decreased IFN-gamma in the presence of preserved IL-4 production. J Immunol 1996; 157:2712-8.
12. Garcia-Sanz JA, Lenig D. Translational control of interleukin 2 messenger RNA as a molecular mechanism of T cell anergy. J Exp Med 1996; 184:159-64.
13. Klausner RD, Donaldson JG, Lippincott-Schwartz J, Brefeldin A. Insights into the control of membrane traffic and organelle structure. J Cell Biol 1992; 116:1071.
14. Picker LJ, Singh MK, Zdraveski Z et al. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood 1995; 86:1408-19.
15. Anderson SJ, Coleclough C. Regulation of CD4 and CD8 expression on mouse T cells: active removal from the surface by two mechanisms. J Immunol 1993; 151:5123.
16. Chun T-W, Carruth L, Finzi D et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 1997; 387:183-8.
17. Mahalingam M, Peakman M, Davies ET, Pozniak A, McManus TJ, Vergani D. T cell activation and disease severity in HIV infection. Clin Exp Immunol 1993; 93:337-43.
18. + T lymphocytes during HIV-1 infection. Clin Exp Immunol 1994; 95:436-41.
19. Mahalingam M, Pozniak A, McManus TJ, Vergani D, Peakman M. Cell cycling in HIV infection: analysis of in vivo activated lymphocytes. Clin Exp Immunol 1995; 102:481-6.
20. Caruso A, Licenziati S, Canaris AD et al. T cells from individuals in advanced stages of HIV-1 infection do not proliferate but express activation antigens in response to HIV-1-specific antigens. J Acquir Immune Defic Syndr Hum Retrovirol 1997; 15:61-69.
21. Wiertz EJ, Mukherjee S, Ploegh HL. Viruses use stealth technology to escape from the host immune system. Mol Med Today 1997; 3:116-23.
22. + lymphocytes after contact with membrane-bound HIV-1 envelope glycoprotein. Virol 1994; 198:360-5.
23. Banda NK, Bernier J, Kurahara DK et al. Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J Exp Med 1992; 176:1099-106.
24. + antigen-specific T cells to undergo apoptosis by HIV-infected monocytes. A two-step mechanism involving the gp120 molecule. J Clin Invest 1997; 99:257-66.
25. Yoo J, Chen H, Kraus T et al. Altered cytokine production and accessory cell function after HIV-1 infection. J Immunol 1996; 157:1313-20.
26. Chirmule N, McCloskey TW, Hu R, Kalyanaraman VS, Pahwa S. HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71). J Immunol 1995; 155:917-24.
27. - T cells. AIDS 1994; 8:431-41.
28. + T cell proliferation in HIV-positive patients as a result of CD28 costimulation. Sci 1996; 272:1939-43.
29. Caruso A, Licenziati S, Canaris AD et al. Characterization of T-cell subsets involved in the production of IFN-gamma in asymptomatic HIV-infected patients. AIDS Res Hum Retroviruses 1996; 12:135-41.
30. Clerici M, Shearer GM. The Th1-Th2 hypothesis of HIV-intection - new insights. Immunol Today 1994; 15:575-81.
31. + T cell homeostasis and function in advanced HIV disease. Sci 1997; 277:112-6