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Volumn 180, Issue 4, 1999, Pages 1057-1063

Restoration of normal interleukin-2 production by CD4+ T cells of human immunodeficiency virus-infected patients after 9 months of highly active antiretroviral therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INDINAVIR; INTERLEUKIN 2; LAMIVUDINE; STAVUDINE;

EID: 0033372246     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315025     Document Type: Article
Times cited : (40)

References (36)
  • 1
    • 0021792148 scopus 로고
    • Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition
    • Lane HC, Depper, JM, Greene WC, Whalen G, Waldmann TA, Fauci AS. Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition. N Engl J Med 1985;313:79-84.
    • (1985) N Engl J Med , vol.313 , pp. 79-84
    • Lane, H.C.1    Depper, J.M.2    Greene, W.C.3    Whalen, G.4    Waldmann, T.A.5    Fauci, A.S.6
  • 2
    • 0024272153 scopus 로고
    • Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs
    • Miedema F, Petit AJ, Terpstra FG, et al. Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs. J Clin invest 1988; 82:1908-14.
    • (1988) J Clin invest , vol.82 , pp. 1908-1914
    • Miedema, F.1    Petit, A.J.2    Terpstra, F.G.3
  • 3
    • 0024786954 scopus 로고
    • Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging
    • Clerici M, Stocks NI, Zajac RA, et al. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging. J Clin Invest 1989; 84:1892-9.
    • (1989) J Clin Invest , vol.84 , pp. 1892-1899
    • Clerici, M.1    Stocks, N.I.2    Zajac, R.A.3
  • 4
    • 0024567058 scopus 로고
    • Lymphocyte proliferative responses to human immunodeficiency virus antigens in vitro
    • Krowka JF, Stites DP, Jain S, et al. Lymphocyte proliferative responses to human immunodeficiency virus antigens in vitro. J. Clin Invest 1989; 83:1198-203.
    • (1989) J. Clin Invest , vol.83 , pp. 1198-1203
    • Krowka, J.F.1    Stites, D.P.2    Jain, S.3
  • 5
    • 0028168943 scopus 로고
    • Changing virus-host interactions in the course of HIV-1 infection
    • Miedema F, Meyaard L, Koot M, et al. Changing virus-host interactions in the course of HIV-1 infection. Immunol Rev 1994; 140:35-72.
    • (1994) Immunol Rev , vol.140 , pp. 35-72
    • Miedema, F.1    Meyaard, L.2    Koot, M.3
  • 6
    • 0030869269 scopus 로고    scopus 로고
    • Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy
    • Gulick RM, Mellors JW, Havlir D, et al. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Engl J Med 1997;337:734-9.
    • (1997) N Engl J Med , vol.337 , pp. 734-739
    • Gulick, R.M.1    Mellors, J.W.2    Havlir, D.3
  • 7
    • 0442268112 scopus 로고    scopus 로고
    • A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less
    • AIDS Clinical Trials Group 320 Study Team
    • Hammer SM, Squires KE, Hughes MD, et al. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med 1997;337:725-33.
    • (1997) N Engl J Med , vol.337 , pp. 725-733
    • Hammer, S.M.1    Squires, K.E.2    Hughes, M.D.3
  • 8
    • 7144229335 scopus 로고    scopus 로고
    • Discrepant responses to triple combination antiretroviral therapy in advanced HIV disease
    • Piketty C, Castiel P, Belec L, et al. Discrepant responses to triple combination antiretroviral therapy in advanced HIV disease. AIDS 1998; 12:745-50.
    • (1998) AIDS , vol.12 , pp. 745-750
    • Piketty, C.1    Castiel, P.2    Belec, L.3
  • 9
    • 0031882434 scopus 로고    scopus 로고
    • Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation
    • Pakker NG, Notermans DW, de Boer RJ, et al. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation. Nat Med 1998; 4:208-14.
    • (1998) Nat Med , vol.4 , pp. 208-214
    • Pakker, N.G.1    Notermans, D.W.2    De Boer, R.J.3
  • 10
    • 0031883405 scopus 로고    scopus 로고
    • Getting to the HAART of T cell dynamics
    • Roederer M, Getting to the HAART of T cell dynamics [news; comment]. Nat Med 1998; 4:145-6.
    • (1998) Nat Med , vol.4 , pp. 145-146
    • Roederer, M.1
  • 11
    • 0031873665 scopus 로고    scopus 로고
    • Limited CD4+ T-cell renewal in early HIV-1 infection: Effect of highly active antiretroviral therapy
    • Fleury S, de Boer RJ, Rizzardi GP, et al. Limited CD4+ T-cell renewal in early HIV-1 infection: effect of highly active antiretroviral therapy. Nat Med 1998; 4:794-801.
    • (1998) Nat Med , vol.4 , pp. 794-801
    • Fleury, S.1    De Boer, R.J.2    Rizzardi, G.P.3
  • 12
    • 0030052964 scopus 로고    scopus 로고
    • Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir
    • Kelleher AD, Carr A, Zaunders J, Cooper DA. Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir. J Infect Dis. 1996;173:321-9.
    • (1996) J Infect Dis. , vol.173 , pp. 321-329
    • Kelleher, A.D.1    Carr, A.2    Zaunders, J.3    Cooper, D.A.4
  • 13
    • 0030868897 scopus 로고    scopus 로고
    • Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
    • Autran B, Garcelain G, Li TS, et al. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 1997; 277:112-6.
    • (1997) Science , vol.277 , pp. 112-116
    • Autran, B.1    Garcelain, G.2    Li, T.S.3
  • 15
    • 17344365057 scopus 로고    scopus 로고
    • Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir: Results of AIDS clinical trials group protocol 315
    • Lederman MM, Connick E, Landay A, et al Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir: results of AIDS Clinical Trials Group Protocol 315. J Infect Dis 1998; 178:70-9.
    • (1998) J Infect Dis , vol.178 , pp. 70-79
    • Lederman, M.M.1    Connick, E.2    Landay, A.3
  • 16
    • 0343742642 scopus 로고    scopus 로고
    • Decline in deaths from AIDS due to new antiretrovirals
    • Hogg RS, O'Shaughnessy MV, Gataric N, et al. Decline in deaths from AIDS due to new antiretrovirals [letter]. Lancet 1997;349:1294.
    • (1997) Lancet , vol.349 , pp. 1294
    • Hogg, R.S.1    O'Shaughnessy, M.V.2    Gataric, N.3
  • 17
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • HIV Outpatient Study Investigators
    • Palella FJ, Jr., Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998;338:853-60.
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella F.J., Jr.1    Delaney, K.M.2    Moorman, A.C.3
  • 18
    • 0032490305 scopus 로고    scopus 로고
    • Longlasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease
    • Li TS, Tubiana R, Katlama G Calvez V, Ait Mohand H, Autran B. Longlasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease. Lancet 1998; 351:1682-86.
    • (1998) Lancet , vol.351 , pp. 1682-1686
    • Li, T.S.1    Tubiana, R.2    Katlama, G.3    Calvez, V.4    Ait Mohand, H.5    Autran, B.6
  • 19
    • 0024550342 scopus 로고
    • Leu 23 induction as an early marker of functional CD3/T cell antigen receptor triggering. Requirement for receptor cross-linking, prolonged elevation of intracellular [Ca++] and stimulation of protein Kinase C
    • Testi R, Phillips JH, Lanier LL. Leu 23 induction as an early marker of functional CD3/T cell antigen receptor triggering. Requirement for receptor cross-linking, prolonged elevation of intracellular [Ca++] and stimulation of protein Kinase C. J Immunol 1989; 142:1854-60.
    • (1989) J Immunol , vol.142 , pp. 1854-1860
    • Testi, R.1    Phillips, J.H.2    Lanier, L.L.3
  • 20
    • 0031909328 scopus 로고    scopus 로고
    • CD4+ T-cell memory, CD45R subsets and the persistence of antigen-a unifying concept
    • Bell EB, Sparshott SM, Bunce C. CD4+ T-cell memory, CD45R subsets and the persistence of antigen-a unifying concept. Immunol Today 1998; 19:60-4.
    • (1998) Immunol Today , vol.19 , pp. 60-64
    • Bell, E.B.1    Sparshott, S.M.2    Bunce, C.3
  • 21
    • 0031849216 scopus 로고    scopus 로고
    • Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults
    • Walker RE, Carter CS, Muul L, et al. Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults. Nat Med 1998; 4:852-6.
    • (1998) Nat Med , vol.4 , pp. 852-856
    • Walker, R.E.1    Carter, C.S.2    Muul, L.3
  • 22
    • 16944367032 scopus 로고    scopus 로고
    • HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies
    • Connors M, Kovacs JA, Krevat S, et al. HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies. Nat Med 1997; 3:533-40.
    • (1997) Nat Med , vol.3 , pp. 533-540
    • Connors, M.1    Kovacs, J.A.2    Krevat, S.3
  • 23
    • 0030842948 scopus 로고    scopus 로고
    • Transient renewal of thymopoiesis in HIV-infected human thymic implants following antiviral therapy
    • Withers-Ward ES, Amado RG, Koka PS, et al. Transient renewal of thymopoiesis in HIV-infected human thymic implants following antiviral therapy. Nat Med 1997; 3:1102-9.
    • (1997) Nat Med , vol.3 , pp. 1102-1109
    • Withers-Ward, E.S.1    Amado, R.G.2    Koka, P.S.3
  • 24
    • 0032104145 scopus 로고    scopus 로고
    • High prevalence of thymic tissue in adults with human immunodeficiency
    • McCune JM, Loftus R, Schmidt DK, et al. High prevalence of thymic tissue in adults with human immunodeficiency. J Clin Invest 1998; 101:2301-8.
    • (1998) J Clin Invest , vol.101 , pp. 2301-2308
    • McCune, J.M.1    Loftus, R.2    Schmidt, D.K.3
  • 26
    • 0033526641 scopus 로고    scopus 로고
    • Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection; A randomised controlled trial
    • ANRS 048 study group
    • Levy Y, Capitant C, Houhou I, et al. Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection; a randomised controlled trial. ANRS 048 study group. Lancet 1999; 353(9168):1923-9.
    • (1999) Lancet , vol.353 , Issue.9168 , pp. 1923-1929
    • Levy, Y.1    Capitant, C.2    Houhou, I.3
  • 27
    • 0033537355 scopus 로고    scopus 로고
    • HIV-1 replication in patients with undetectable plasma virus receiving Highly active antiretroviral therapy
    • Natarajan V, Bosche M, Metcalf JA, Ward DJ, Lane HC, Kovacs JA, HIV-1 replication in patients with undetectable plasma virus receiving Highly active antiretroviral therapy [letter]. Lancet 1999; 353:119-20.
    • (1999) Lancet , vol.353 , pp. 119-120
    • Natarajan, V.1    Bosche, M.2    Metcalf, J.A.3    Ward, D.J.4    Lane, H.C.5    Kovacs, J.A.6
  • 28
    • 0030048020 scopus 로고    scopus 로고
    • Predominant involvement of CD8+CD28- lymphocytes in human immunodeficiency virus-specific cytotoxic activity
    • Fiorentiono S, Dalod M, Olive D, Guillet JG, Gomard E Predominant involvement of CD8+CD28- lymphocytes in human immunodeficiency virus-specific cytotoxic activity. J Virol 1996; 70:2022-6.
    • (1996) J Virol , vol.70 , pp. 2022-2026
    • Fiorentiono, S.1    Dalod, M.2    Olive, D.3    Guillet, J.G.4    Gomard, E.5
  • 29
    • 0028295331 scopus 로고
    • Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cell
    • Borthwick NJ, Bofill M, Gombert WM, et al. Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cell. AIDS 1994; 8:431-41.
    • (1994) AIDS , vol.8 , pp. 431-441
    • Borthwick, N.J.1    Bofill, M.2    Gombert, W.M.3
  • 30
    • 0029824382 scopus 로고    scopus 로고
    • Low T cell reactivity to combined CD3 plus CD28 stimulation is predictive for progression to AIDS: Correlation with decreased CD28 expression
    • Roos MT, Miedema F, Meinesz AP, et al. Low T cell reactivity to combined CD3 plus CD28 stimulation is predictive for progression to AIDS: correlation with decreased CD28 expression. Clin Exp Immunol 1996; 105:409-15.
    • (1996) Clin Exp Immunol , vol.105 , pp. 409-415
    • Roos, M.T.1    Miedema, F.2    Meinesz, A.P.3
  • 31
    • 0031936570 scopus 로고    scopus 로고
    • Abnormal intracellular IL-2 and interferon-gamma (IFN-gamma) production as HIV-1-associated markers of immune dysfunction
    • Westby M, Marriott JB, Guçkian M, Cookson S, Hay P, Dalgleish AG. Abnormal intracellular IL-2 and interferon-gamma (IFN-gamma) production as HIV-1-associated markers of immune dysfunction. Clin Exp Immunol 1998; 111:257-63.
    • (1998) Clin Exp Immunol , vol.111 , pp. 257-263
    • Westby, M.1    Marriott, J.B.2    Guçkian, M.3    Cookson, S.4    Hay, P.5    Dalgleish, A.G.6
  • 32
    • 0030587189 scopus 로고    scopus 로고
    • Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals; de-creased IFN-gamma in the presence of preserved IL-4 production
    • Meyaard L, Hovenkamp E, Keet IP, et al. Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals; de-creased IFN-gamma in the presence of preserved IL-4 production. J Immunol 1996; 157:2712-8.
    • (1996) J Immunol , vol.157 , pp. 2712-2718
    • Meyaard, L.1    Hovenkamp, E.2    Keet, I.P.3
  • 33
    • 0028232637 scopus 로고
    • TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients
    • Barcellini W, Rizzardi GP, Borghi MO, Fain C, Lazzarin A, Meroni PL. TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients. AIDS 1994;8:757-62.
    • (1994) AIDS , vol.8 , pp. 757-762
    • Barcellini, W.1    Rizzardi, G.P.2    Borghi, M.O.3    Fain, C.4    Lazzarin, A.5    Meroni, P.L.6
  • 34
    • 0027332299 scopus 로고
    • Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection
    • Fan J. Buss HZ Fahey JL. Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection J Immunol 1993; 151:5031-40.
    • (1993) J Immunol , vol.151 , pp. 5031-5040
    • Fan, J.1    Buss, H.Z.2    Fahey, J.L.3
  • 35
    • 17344369291 scopus 로고    scopus 로고
    • Improvement in cell-mediated immune function during potent anti-human immunodeficiency virus therapy with ritonavir plus saquinavir
    • Angel JB, Kumar A, Parato K, et al. Improvement in cell-mediated immune function during potent anti-human immunodeficiency virus therapy with ritonavir plus saquinavir. J Infect Dis 1998; 177:898-904.
    • (1998) J Infect Dis , vol.177 , pp. 898-904
    • Angel, J.B.1    Kumar, A.2    Parato, K.3
  • 36
    • 0031907427 scopus 로고    scopus 로고
    • Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy
    • Gorochov G, Neumann AU, Kereveur A et al. Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy. Nut Med 1998; 4:215-21.
    • (1998) Nut Med , vol.4 , pp. 215-221
    • Gorochov, G.1    Neumann, A.U.2    Kereveur, A.3


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