Neuronal apoptosis following cerebral ischaemia. Basic principles, pathophysiology and therapeutic strategies;Neuronale apoptose nach zerebraler ischämie. Grundlagen, pathophysiologie und interventionsmöglichkeiten

Anaesthesist

Volumn 50, Issue 12, 2001, Pages 905-920

  Padosch, S A ^a   Vogel, P ^a   Bottiger B W ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Apoptosis; Caspase inhibitors; Caspases; Global focal cerebral ischaemia; Programmed cell death

Indexed keywords

CASPASE INHIBITOR; PROTEIN DERIVATIVE;

APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CAENORHABDITIS ELEGANS; CELL DEATH; CELL STRUCTURE; CONTROLLED STUDY; HUMAN; NERVE CELL; NERVE DEGENERATION; NEUROPROTECTION; PATHOPHYSIOLOGY;

ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; HUMANS; ISCHEMIC ATTACK, TRANSIENT; NEURONS; NEUROPROTECTIVE AGENTS;

EID: 0035675657     PISSN: 00032417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00101-001-0247-8     Document Type: Article

References (110)

1. Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases
2. Central nervous system complications of cardiac surgery
3. Death receptors: Signaling and modulation
4. HIV and Apoptosis. Death and the mitochondrion
5. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
6. Efficacy and safety of thrombolytic therapy after initially unsuccessful cardiopulmonary resuscitation: A prospective clinical trial
7. Long term outcome after out-of-hospital cardiac arrest with physician staffed emergency medical services: The Utstein style applied to a mid-sized urban/suburban area
8. Neuronal stress response and neuronal cell damage after cardiocirculatory arrest in rats
9. Global cerebral ischemia due to cardiocirculatory arrest in mice causes neuronal degeneration and early induction of transcription factor genes in the hippocampus
10. Cerebral complications of hypotensive Anaesthesia in a healthy adult
11. BCL-2 family: Regulators of cell death
12. Apoptosis repressor genes Bcl-2 and Bcl-x-long are expressed in the rat brain following global ischemia
13. Induction of caspase-3-ike protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia
14. Suppression of endogenous bcl-2 expression by antisense treatment exacerbates ischemic neuronal death
15. Expression of the apoptosis-effector gene, Bax, is up-regulated in vulnerable hippocampal CA1 neurons following global ischemia
16. Conversion of Bcl-2 to a Bax-like death effector by caspases
17. Repetitive ischemia/reperfusion potentiates hepatocellular death by apoptosis
18. Modulation of cell death by Bcl-XL through caspase interaction
19. Amnesia with hippocampal lesions after cardiopulmonary arrest
20. Activation of a CrmA-insenstiive, p3S-sensitive pathway in ionizing radiation-induced apoptosis
21. Hypoxic amnesia following heart arrest. A neuropsychological case study
22. Chronicity of memory impairment in long-term out-of-hospital cardiac arrest survivors
23. Very delayed infarction after mild focal cerebral ischemia: A role for apoptosis?
24. Nuclear changes in apoptosis
25. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
26. Intracellular ATP levels determine cell death fate by apoptosis or necrosis
27. Caspase inhibitors
28. Caspase pathways, neuronal apoptosis, and CNS injury
29. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family
30. Stroke hospitalization and case-fatality in the United States 1988-1997
31. Genes that affect cell fates during the development of Caenorhabditis elegans
32. Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia
33. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
34. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production
35. Activation of CPP-32 protease in hippocampal neurons following ischemia and epilepsy
36. Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats
37. Cerebral resuscitation from cardiac arrest: Treatment potentials
38. CASH, a novel caspase homologue with death effector domains
39. Bcl-2 family gene products in cerebral ischemia and traumatic brain injury
40. Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro
41. Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease
42. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death
43. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian protooncogene bcl-2
44. A caspase inhibitor blocks ischaemia-induced delayed neuronal death in the gerbil
45. The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death
46. Defining apoptosis
47. Delayed neuronal death and delayed neuronal recovery in the human brain following global ischemia
48. Experimental models for the investigation of brain ischemia
49. Apoptosis in the basal ganglia of the developing human nervous system
50. The digestion of cellular fragments within phagolysosomes in carcinoma cells
51. A mode of cell loss in malignant neoplasms
52. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
53. Amelioration of hippocampal neuronal damage after global ischemia by neuronal overexpression of BCL-2 in transgenic mice
54. Localization of apoptotic macrophages at the site of plaque rupture in sudden coronary death
55. Apoptosis generates stable fragments of human type 1 keratins
56. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
57. Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
58. Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli
59. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
60. Intact, injured, necrotic and apoptotic cells after focal cerebral ischemia in the rat
61. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia
62. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats
63. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
64. Activation of caspase-3 in permanent and transient brain ischaemia in man
65. Gene expression induced by cerebral ischemia: An apoptotic perspective
66. Apoptosis, oncosis, and necrosis. An overview of cell death
67. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
68. CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons
69. Caspase-mediated cleavage of cytoskeletal actin plays a positive role in the process of morphological apoptosis
70. Signalling by proteolysis: Death receptors induce apoptosis
71. Apoptotic DNA fragmentation
72. Delayed hippocampal damage in humans following cardiorespiratory arrest
73. Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum
74. Why is cardiac arrest lasting more than five minutes associated with poor neurologic outcome?
75. Programmed cell death in the developing human telencephalon
76. CD95 (Fas)-induced caspase-mediated proteolysis of NF-kappaB
77. Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme
78. Apoptosis promotes a caspase-induced amino-terminal truncation of IkappaBalpha that functions as a stable inhibitor of NF-kappaB
79. Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease
80. Neuropsychological sequelae of cardiac arrest
81. Fas (CD95/APO-1) plays a role in the pathophysiology of focal cerebral ischemia
82. Selective loss and selective sparing of neurons in the thalamic reticular nucleus following human cardiac arrest
83. The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis
84. Caspases as treatment targets in stroke and neurodegenerative diseases
85. An electron-microscope study of the mode of cell death induced by cancer-chemotherapeutic agents in populations of proliferating normal and neoplastic cells
86. Early neurological complications of coronary artery bypass surgery
87. Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury
88. Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia
89. Electron microscopic autoradiography of germinal center cells in mouse spleen
90. CrmA/SPI-2 inhibition of an endogenous ICE-related protease responsible for lamin A cleavage and apoptotic nuclear fragmentation
91. Regulation of apoptosis by viral gene products
92. Einfluss einer antiapoptotischen Intervention mittels Inhibierung van Caspasen auf die neuronale Degeneration und das Outcome nach Herz-Kreislaufstillstand
93. Apoptosis in the pathogenesis and treatment of disease
94. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
95. Caspases: Enemies within
96. Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones
97. Therapeutic neutralization of CD95 ligand and TNF attenuates brain damage in stroke
98. Activation of intracellular proteases is an early event in TNF-induced apoptosis
99. Early delineation of ischemic tissue in rat brain cryosections by high-contrast staining
100. The characterization of an amnesic syndrome following hypoxic ischemic injury
101. Cleavage of sterol regulatory element binding proteins [SREBPs) by CPP32 during apoptosis
102. Neuron-specific transgene expression of Bcl-XL but not Bcl-2 genes reduced lesion size after permanent middle cerebral artery occlusion in mice
103. Overexpression of the cell death suppressor Bcl-w in ischemic brain: Implications for a neuroprotective role via the mitochondrial pathway
104. Evolutionary conservation of a genetic pathway of programmed cell death
105. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
106. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-13-3 not BCL-X(L)
107. Processing and activation of pro-interleukin-16 by caspase-3
108. Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/pB5 complex
109. Human amnesia and the medial temporal region: Enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus
110. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3