Suppression of endogenous bcl-2 expression by antisense treatment exacerbates ischemic neuronal death

Journal of Cerebral Blood Flow and Metabolism

Volumn 20, Issue 7, 2000, Pages 1033-1039

  Chen, Jun ^a,b   Simon, Roger P ^a,b   Nagayama, Tesuya ^a   Zhu, Raymond ^a   Eric Loeffert, J ^a   Watkins, Simon C ^a   Graham, Steven H ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

Author keywords

Antisense; Bcl 2; Cerebral ischemia

Indexed keywords

PROTEIN BCL 2;

ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT;

EID: 0033934180     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200007000-00002     Document Type: Article

References (10)

1. Chen J, Graham SH, Chan PH, Lan J, Zhou RL, Simon RP (1995) bcl-2 is expressed in neurons that survive focal ischemia in the rat. Neuroreport 6:394-398
2. Chen J, Graham SH, Nakayama M, Zhu RL, Jin KL, Stetler RA, Simon RP (1997) Apoptosis repressor genes bcl-2 and bcl-x-long are expressed in the rat brain following global ischemia. J Cereb Blood Flow Metabol 17:1-10
3. Chen J, Zhu RL, Nakayama M, Kawaguchi K, Jin K, Stetler RA, Simon RP, Graham SH (1996) Expression of the apoptosis-effector gene, Bax, is up-regulated in vulnerable hippocampal CA1 neurons following global ischemia. J Neurochem 67:64-71
4. Clark RSB, Chen J, Watkins SC, Kochanek PM, Chen M, Stetler RA, Loeffert JE, Graham SH (1997) Apoptosis-suppressor gene bcl-2 expression after traumatic brain injury in rats. J Neurosci 17:9172-82
5. Dixon EP, Stephenson DT, Clemens JA, Little SP (1997) Bcl-X short is elevated following severe global ischemia in rat brains. Brain Res 776:222-9
6. Niwa M, Hara A, Iwai T, Sassa T, Mori H, Uematsu T (1997) Expression of Bax and Bcl-2 protein in the gerbil hippocampus following transient forebrain ischemia and its modification by phencyclidine. Neural Res 19:629-33
7. Sato T, Irie S, Krajewski S, Reed JC (1994) Cloning and sequencing of a cDNA encoding the rat Bcl-2 protein. Gene 140:291-292
8. Shears SB, Bronk JR (1980) Ion transport in liver mitochondria from normal and thyroxine-treated rats. J Bioenerg Biomembr 12:379-93
9. Simon RP, Griffiths T, Evans MC, Swan JH, Meldrum BS (1984) Calcium overload in selectively vulnerable neurons of the hippocampus during and after ischemia: an electron microscopy study in the rat. J Cereb Blood Flow Metab 4:350-61
10. Sorger PK, Pelham HR (1987) Cloning and expression of a gene encoding hsc73, the major hsp70-like protein in unstressed rat cells. EMBO J 6:993-8